A predictive chromatin architecture nexus regulates transcription and DNA damage repair

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108300 - 108300

Published: Feb. 1, 2025

Genomes are blueprints of life essential for an organism's survival, propagation, and evolutionary adaptation. Eukaryotic genomes comprises DNA, core histones several other nonhistone proteins packaged into chromatin in the tiny nucleus. Chromatin structural organization restricts transcription protein DNA access, permitting binding only after specific remodelling events. The fundamental processes living cells, including transcription, replication, repair, recombination, thus regulated by structure through ATP-dependent remodelling, histone variant incorporation, various covalent modifications phosphorylation, acetylation, ubiquitination. These modifications, particularly involving H2AX, furthermore play crucial roles damage responses enabling repair access to damage. also stabilizes genome regulating mechanisms while suppressing from endogenous exogenous sources. Environmental factors such as ionizing radiations induce damage, if is compromised, can lead chromosomal abnormalities gene amplifications observed tumor types. Consequently architecture controls blueprint fidelity activity: it orchestrates correct expression, genomic integrity, recombination. This review considers connecting functional outcomes impacting integrity emerging grand challenge predictive molecular cell biology.

Language: Английский

R-loop homeostasis in genome dynamics, gene expression and development

Current Opinion in Genetics & Development, Journal Year: 2025, Volume and Issue: 92, P. 102325 - 102325

Published: March 4, 2025

Language: Английский

BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский