In vivo Delivery Processes and Development Strategies of Lipid Nanoparticles DOI

Jiashun Cheng,

Lina Jian, Zhaolin Chen

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Lipid nanoparticles (LNPs) represent an advanced and highly efficient delivery system for RNA molecules, demonstrating exceptional biocompatibility remarkable efficiency. This is evidenced by the clinical authorization of three LNP formulations: Patisiran, BNT162b2, mRNA-1273. To further maximize efficacy RNA-based therapy, it imperative to develop more potent systems that can effectively protect inherently unstable negatively charged molecules from degradation nucleases, while facilitating their cellular uptake into target cells. Therefore, this review presents feasible strategies commonly employed development systems. The encompass combinatorial chemistry large-scale synthesis ionizable lipids, rational design strategy functional molecules-derived lipid optimization formulations, adjustment particle size charge property LNPs. Prior introducing these developing strategies, in vivo processes LNPs, a crucial determinant influencing translation described better understand how

Language: Английский

Drug delivery strategies with lipid-based nanoparticles for Alzheimer’s disease treatment DOI Creative Commons
Young‐Ju Jang,

Seong-Jun Kang,

Hyun Su Park

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 10, 2025

Alzheimer's disease (AD) is a distinctive form of dementia characterized by age-related cognitive decline and memory impairment. A key hallmark AD the irreversible overaccumulation beta-amyloid (Aβ) in brain, associated with neuroinflammation neuronal death. Although Aβ clearance immunoregulation have been major therapeutic strategies for AD, highly selective transport across blood–brain barrier (BBB) negatively affects delivery efficacy drugs without ability to cross BBB. In this review, we discuss potential lipid-based nanoparticles (LBNs) as promising vehicles drug treatment. LBNs, composed phospholipid mono- or bilayer, attracted attention due their exceptional cellular penetration capabilities loading capabilities, which also facilitate cargo transcytosis Recent advances development engineering LBNs overcome existing limitations current clinical approaches treatment addressing off-target effects low efficacy. Here, review pathways BBB, well various types therapy, including exosomes, liposomes, solid lipid (SLNs), nanostructured carriers (NLCs), elucidate properties, preparation methodologies, efficacy, thereby offering innovative avenues novel translation therapy.

Language: Английский

Citations

4
Recent advances in self-targeting natural product-based nanomedicines DOI Creative Commons

Haifan Liu,

Xingyue Jin, Suyi Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 20, 2025

Language: Английский

Citations

3
Advanced Nanoparticle Engineering for Precision Therapeutics of Brain Diseases DOI
Muhammad Ismail, Jiayi Liu,

Ningyang Wang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138

Published: Jan. 28, 2025

Language: Английский

Citations

2
Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications DOI Open Access
Corneliu Toader, Adrian Dumitru,

Lucian Eva

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13302 - 13302

Published: Dec. 11, 2024

This review aims to address the significant challenges of treating central nervous system (CNS) disorders such as neurodegenerative diseases, strokes, spinal cord injuries, and brain tumors. These are difficult manage due complexity disease mechanisms protective blood–brain barrier (BBB), which restricts drug delivery. Recent advancements in nanoparticle (NP) technologies offer promising solutions, with potential applications delivery, neuroprotection, neuroregeneration. By examining current research, we explore how NPs can cross BBB, deliver medications directly targeted CNS regions, enhance both diagnostics treatment. Key NP strategies, passive targeting, receptor-mediated transport, stimuli-responsive systems, demonstrate encouraging results. Studies show that may improve minimize side effects, increase therapeutic effectiveness models Alzheimer’s, Parkinson’s, stroke, glioblastoma. thus represent a approach for disorder management, combining delivery diagnostic capabilities enable more precise effective treatments could significantly benefit patient outcomes.

Language: Английский

Citations

4
Developing mRNA Nanomedicines with Advanced Targeting Functions DOI Creative Commons
Ji Wang, Lijun Cai, Ning Li

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 21, 2025

The emerging messenger RNA (mRNA) nanomedicines have sprung up for disease treatment. Developing targeted mRNA has become a thrilling research hotspot in recent years, as they can be precisely delivered to specific organs or tissues enhance efficiency and avoid side effects. Herein, we give comprehensive review on the latest progress of with targeting functions. its carriers are first described detail. Then, mechanisms passive targeting, endogenous active outlined, focus various biological barriers that may encounter during vivo delivery. Next, emphasis is placed summarizing mRNA-based organ-targeting strategies. Lastly, advantages challenges clinical translation mentioned. This expected inspire researchers this field drive further development technology.

Language: Английский

Citations

0
Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics DOI Creative Commons

Xufei Bian,

Qian Guo, Lee‐Fong Yau

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 10, 2025

Lipid nanoparticles have shown success in targeting major organs such as the liver, spleen, and lungs, but crossing blood-brain barrier (BBB) remains a challenge. Effective brain-targeted delivery systems are essential for advancing gene therapy neurological diseases remain limited by low transport efficiency poor nucleic acid stability. Here, we report library of ionizable lipids based on tetrahydroisoquinoline structure protoberberine alkaloids, designed to improve BBB penetration via dopamine D3 receptor-mediated endocytosis. These offer three key advantages: enhanced brain uptake, improved stability through poly(A) self-assembly, minimal immunogenicity with inherent neuroprotective properties. In murine models, they demonstrate therapeutic potential Alzheimer's disease, glioma, cryptococcal meningitis. This berberine-inspired system integrates precise receptor stabilization, offering promising platform therapeutics. Delivering RNA therapies is challenging due barrier. authors show models that lipid nanoparticle enhances receptors, enabling effective treatment diseases.

Language: Английский

Citations

0
Targeting Neuroinflammation in Central Nervous System Diseases by Oral Delivery of Lipid Nanoparticles DOI Creative Commons
Yuan Zou, Jing Zhang, Longmin Chen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 388 - 388

Published: March 18, 2025

Neuroinflammation within the central nervous system (CNS) is a primary characteristic of CNS diseases, such as Parkinson’s disease, Alzheimer’s disease (AD), amyotrophic lateral sclerosis, and mental disorders. The excessive activation immune cells results in massive release pro-inflammatory cytokines, which subsequently induce neuronal death accelerate progression neurodegeneration. Therefore, mitigating neuroinflammation has emerged promising strategy for treatment diseases. Despite advancements drug discovery development novel therapeutics, effective delivery these agents to remains serious challenge due restrictive nature blood–brain barrier (BBB). This underscores need develop system. Recent studies have identified oral lipid nanoparticles (LNPs) approach efficiently deliver drugs across BBB treat neurological review aims comprehensively summarize recent LNPs designed controlled therapeutic modulation diseases through administration. Furthermore, this addresses mechanisms by overcome biological barriers evaluate their clinical implications efficacy context systems. Specifically, it focuses on LNP formulations that facilitate administration, exploring potential enhance bioavailability, improve targeting precision, alleviate or manage symptoms associated with range

Language: Английский

Citations

0
Vinpocetine-mediated multidimensional active targeted delivery across the blood-brain barrier DOI
Zhongyi Ma, Xinlong Liu, Xinyu Xie

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 382, P. 113768 - 113768

Published: April 22, 2025

Language: Английский

Citations

0
Drug Delivery Across the Blood–Brain Barrier: A New Strategy for the Treatment of Neurological Diseases DOI Creative Commons

Jiao Yang,

Lin Yang,

Rujuan Wang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1611 - 1611

Published: Dec. 19, 2024

The blood–brain barrier (BBB) serves as a highly selective between the blood and central nervous system (CNS), its main function is to protect brain from foreign substances. This physiological property plays crucial role in maintaining CNS homeostasis, but at same time greatly limits delivery of drug molecules CNS, thus posing major challenge for treatment neurological diseases. Given that high incidence low cure rate diseases have become global public health problem, development effective BBB penetration technologies important enhancing efficiency delivery, reducing systemic toxicity, improving therapeutic outcomes review describes pathological properties BBB, well current challenges trans-BBB detailing structural basis protection. Secondly, this paper reviews strategies recent years, including physical, biological chemical approaches, nanoparticle-based technologies, provides comprehensive assessment effectiveness, advantages limitations these strategies. It hoped will provide valuable references inspiration future researchers studies

Language: Английский

Citations

2
In vivo Delivery Processes and Development Strategies of Lipid Nanoparticles DOI

Jiashun Cheng,

Lina Jian, Zhaolin Chen

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Lipid nanoparticles (LNPs) represent an advanced and highly efficient delivery system for RNA molecules, demonstrating exceptional biocompatibility remarkable efficiency. This is evidenced by the clinical authorization of three LNP formulations: Patisiran, BNT162b2, mRNA-1273. To further maximize efficacy RNA-based therapy, it imperative to develop more potent systems that can effectively protect inherently unstable negatively charged molecules from degradation nucleases, while facilitating their cellular uptake into target cells. Therefore, this review presents feasible strategies commonly employed development systems. The encompass combinatorial chemistry large-scale synthesis ionizable lipids, rational design strategy functional molecules-derived lipid optimization formulations, adjustment particle size charge property LNPs. Prior introducing these developing strategies, in vivo processes LNPs, a crucial determinant influencing translation described better understand how

Language: Английский

Citations

0