CG17192 is a Phospholipase That Regulates Signaling Lipids in the Drosophila Gut upon Infection DOI
Kundan Kumar,

Mrunal Pazare,

Girish S. Ratnaparkhi

et al.

Biochemistry, Journal Year: 2024, Volume and Issue: 63(22), P. 3000 - 3010

Published: Oct. 23, 2024

The chemoproteomics technique, activity-based protein profiling (ABPP), has proven to be an invaluable tool in assigning functions enzymes. serine hydrolase (SH) enzyme superfamily, particular, served as excellent example displaying the versatility of various ABPP platforms and resulted a comprehensive cataloging biochemical activities associated within this superfamily. Besides SHs, mammals, several other classes have been thoroughly investigated using platforms. However, utility fly models remains underexplored. Realizing knowledge gap, leveraging complementary platforms, we reported full array SH during developmental stages adult tissues fruit (

Language: Английский

Regulation of Gut Starvation Responses Through DrosophilaNP3253 Neurons DOI Open Access

Quang‐Dat Nguyen,

Kiho Fujii,

Kentaro Ishibashi

et al.

Genes to Cells, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 4, 2025

ABSTRACT The “gut–brain axis,” a bidirectional communication system between the gastrointestinal tract and central nervous system, plays crucial role in regulating complex physiological functions response to nutrients, pathogens, microbiota. However, cellular molecular mechanisms governing this regulation remain poorly understood. Using Drosophila melanogaster as model organism, we previously identified NP3253 neurons, located both brain gut, key contributors gut homeostasis during oral bacterial infection. Here, found novel of neurons starvation resistance. We observed that subset were activated starvation. To investigate downstream effect, conducted RNA‐Seq analysis on adult flies with genetically silenced comparing gene expression under starved fed conditions. This 26 genes differentially expressed neuronal activity. Among these, CG12643 , encoding an uncharacterized short peptide, was be essential for resistance gut. Our findings demonstrate modulate starvation, thereby supporting adaptation environmental stressors.

Language: Английский

Citations

0
Diabetes and the associated complications: The role of antioxidants in diabetes therapy and care DOI Open Access

Lowell Dilworth,

Dewayne Stennett,

Aldeam Facey

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117641 - 117641

Published: Nov. 13, 2024

Language: Английский

Citations

3
Inter-organ communication in Drosophila: Lipoproteins, adipokines, and immune-metabolic coordination DOI
Akhila Rajan, Jason Karpac

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 94, P. 102508 - 102508

Published: April 6, 2025

Language: Английский

Citations

0
CG17192 is a Phospholipase That Regulates Signaling Lipids in the Drosophila Gut upon Infection DOI
Kundan Kumar,

Mrunal Pazare,

Girish S. Ratnaparkhi

et al.

Biochemistry, Journal Year: 2024, Volume and Issue: 63(22), P. 3000 - 3010

Published: Oct. 23, 2024

The chemoproteomics technique, activity-based protein profiling (ABPP), has proven to be an invaluable tool in assigning functions enzymes. serine hydrolase (SH) enzyme superfamily, particular, served as excellent example displaying the versatility of various ABPP platforms and resulted a comprehensive cataloging biochemical activities associated within this superfamily. Besides SHs, mammals, several other classes have been thoroughly investigated using platforms. However, utility fly models remains underexplored. Realizing knowledge gap, leveraging complementary platforms, we reported full array SH during developmental stages adult tissues fruit (

Language: Английский

Citations

1