Unified approaches in transition metal catalyzed C(sp3)–H functionalization: recent advances and mechanistic aspects
Jagrit Grover,
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Amal Tom Sebastian,
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S.K. Maiti
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et al.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Direct
alteration
of
unactivated
C–H
bonds
organic
building
blocks.
Language: Английский
A Catalytic Version of the Knorr Pyrrole Synthesis Permits Access to Pyrroles and Pyridines
Max Leinert,
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Τ. Irrgang,
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Rhett Kempe
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et al.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(46), P. 32098 - 32104
Published: Nov. 11, 2024
Aromatic
N-heterocycles,
such
as
pyrroles
and
pyridines,
are
important
natural
products
bulk
fine
chemicals
with
numerous
applications
active
ingredients
of
pharmaceuticals
agrochemicals,
catalysts,
in
materials
sciences.
We
report
here
a
catalytic
version
the
Knorr
pyrrole
synthesis
which
simple
diversely
available
starting
materials,
1,2-amino
alcohols
or
1,3-amino
keto
esters,
undergo
dehydrogenative
coupling
to
form
respectively.
Our
reaction
forms
hydrogen
collectible
(and
usable)
byproduct
is
mediated
by
well-defined
Mn
catalyst.
The
highly
functionalized
heterocycles
was
demonstrated,
35
compounds,
not
yet
reported
literature,
were
introduced.
Language: Английский
Adsorption and reaction of 2-methylbenzimidazole molecules on a partially oxidized Cu(110) surface
Minlu Zhou,
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Xinle Lu,
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Rong Sun
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et al.
The Journal of Chemical Physics,
Journal Year:
2025,
Volume and Issue:
162(17)
Published: May 2, 2025
N-Heterocyclic
carbenes
(NHCs)
have
emerged
as
a
promising
candidate
for
functionalizing
and
modifying
metal
surfaces.
Despite
extensive
research,
the
influence
of
oxides,
which
frequently
occur
on
surfaces,
adsorption
behavior
NHCs
has
received
limited
attention
at
nanometric
scale.
In
this
study,
configurations
reactions
2-methylbenzimidazole
(MBI)
molecules
CuO/Cu(110)
surface
were
investigated
using
scanning
tunneling
microscopy
non-contact
atomic
force
(nc-AFM).
Following
deposition
MBI
molecules,
Cu
islands
observed,
predominantly
adsorbed
in
flat-lying
configuration.
Comparative
experiments
conducted
bare
Cu(110)
indicate
that
dehydrogenation
due
to
cleavage
N–H
bonds
leads
CuO
reduction
release
adatoms,
subsequently
aggregate
into
islands.
Upon
annealing
378
K,
strips
assume
tilted
configuration,
suggesting
formation
coordination
between
nitrogen
copper
atoms.
On
regions,
assemble
double-chains,
adopting
an
upright
High-resolution
nc-AFM
images
reveal
similarity
double-chains
those
step
edges,
implying
atoms
are
extracted
from
terraces
form
slots
where
preferentially
occupy.
Language: Английский
Synthesis of lactones and lactams via C(sp3)–H bond functionalization
E. Premkumar,
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Ramdas Sreedharan,
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Premananda Ghosh
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et al.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
this
review,
we
have
showcased
the
diverse
aspects
of
transition-metal
catalysis,
biocatalysis,
and
photocatalytic
C(sp
3
)–H
bond
functionalization
to
access
lactones
lactams.
Language: Английский