Functional and Structural Connectivity of the subregions of the Amygdala in ADHD children with or without ODD DOI Creative Commons

Zhao-Min Wu,

Peng Wang,

Xuechun Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Objectives The current study aimed to investigate the structural and functional connectivity of subregions amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid Oppositional Defiant (ODD). Methods A total 354 ADHD-only, 161 ADHD ODD (ADHD + ODD) 100 healthy controls were enrolled. Several rating scales filled out by caregivers. Analysis covariance (ANCOVA) was performed test group-wise differences these behavioral measures. subsample comprising 209 participants went through a resting-state MRI scan Diffusion Tensor Imaging (DTI) scan. Functional calculated using bilateral Amygdala as seeds. Between-group voxel-wise comparisons conducted. Results group had more anxious/depressed moods, delinquent aggressive behaviors, emotional control problems, inhibition deficits than ADHD-only (all PBonferroni−corrected < 0.05). Compared groups, displayed increased FC strength between left caudate, putamen, frontal cortex. Regarding (SC), demonstrated higher streamline density internal capsule, corpus callosum, right superior corona radiata. altered SC associated problems ADHD, while other ADHD-related clinical features. Conclusions Altered compared their counterparts respectively problems. Clinical trial number not applicable

Language: Английский

Amygdalo-cortical dialogue underlies memory enhancement by emotional association DOI Creative Commons
Yoshihito Saito, Yuma Osako, Maya Odagawa

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
A nociceptive amygdala-striatal pathway for chronic pain aversion DOI Creative Commons
Jessica A. Wojick, Alekh Paranjapye,

Juliann K. Chiu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

The basolateral amygdala (BLA) is essential for assigning positive or negative valence to sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of

Language: Английский

Citations

6
Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD DOI Creative Commons

Zhao-Min Wu,

Peng Wang, Xuechun Liu

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 24, 2025

The current study aimed to investigate the structural and functional connectivity of subregions amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid Oppositional Defiant (ODD). A total 354 ADHD-only, 161 ADHD ODD (ADHD + ODD), 100 healthy controls were enrolled. Child Behavior Checklist (CBCL) Rating Inventory Executive Function (BRIEF) filled out by caregivers. Analysis covariance (ANCOVA) was performed test group-wise differences these behavioral measures. subsample comprising 209 participants underwent a resting-state MRI scan diffusion-weighted imaging (DWI) scan. Functional calculated using bilateral Amygdala as seeds. Between-group voxel-wise comparisons conducted. group had more anxious/depressed moods, delinquent aggressive behaviors, emotional control problems, inhibition deficits than ADHD-only (all PBonferroni-corrected < 0.05). Compared groups, displayed increased FC strength between left caudate, putamen, frontal cortex. Regarding (SC), demonstrated higher streamline density internal capsule, corpus callosum, right superior corona radiata. altered SC associated problems ADHD, while other ADHD-related clinical features. Altered compared their counterparts respectively problems. not applicable.

Language: Английский

Citations

0
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates DOI Creative Commons
Michael S. Totty, Rita Cervera‐Juanes, Svitlana V. Bach

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 19, 2024

The amygdaloid complex mediates learning, memory, and emotions. Understanding the cellular anatomical features that are specialized in amygdala of primates versus other vertebrates requires a systematic, anatomically-resolved molecular analysis constituent cell populations. We analyzed five nuclear subdivisions primate with single-nucleus RNA sequencing macaques, baboons, humans to examine gene expression profiles for excitatory inhibitory neurons confirmed our results single-molecule FISH analysis. identified distinct subtypes

Language: Английский

Citations

1
Interconnected neural circuits mediating social reward DOI
Jennifer Isaac, Malavika Murugan

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

1
Functional and Structural Connectivity of the subregions of the Amygdala in ADHD children with or without ODD DOI Creative Commons

Zhao-Min Wu,

Peng Wang,

Xuechun Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Objectives The current study aimed to investigate the structural and functional connectivity of subregions amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid Oppositional Defiant (ODD). Methods A total 354 ADHD-only, 161 ADHD ODD (ADHD + ODD) 100 healthy controls were enrolled. Several rating scales filled out by caregivers. Analysis covariance (ANCOVA) was performed test group-wise differences these behavioral measures. subsample comprising 209 participants went through a resting-state MRI scan Diffusion Tensor Imaging (DTI) scan. Functional calculated using bilateral Amygdala as seeds. Between-group voxel-wise comparisons conducted. Results group had more anxious/depressed moods, delinquent aggressive behaviors, emotional control problems, inhibition deficits than ADHD-only (all PBonferroni−corrected < 0.05). Compared groups, displayed increased FC strength between left caudate, putamen, frontal cortex. Regarding (SC), demonstrated higher streamline density internal capsule, corpus callosum, right superior corona radiata. altered SC associated problems ADHD, while other ADHD-related clinical features. Conclusions Altered compared their counterparts respectively problems. Clinical trial number not applicable

Language: Английский

Citations

0