Biaxially chiral compounds: research and development of synthesis DOI

Kongling Feng,

Chaochao Yao,

Hao Xu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

To date, two asymmetric catalytic methods have been established for the synthesis of biaxially chiral molecules: transition-metal-catalysis and organocatalysis.

Language: Английский

Copper-catalyzed Larock-type cyclization/debenzylation of yne-allylic esters with aliphatic amines DOI

Rongkang Huang,

Yuepeng Lu,

Feng Xu

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0
Copper-catalyzed γ-selective yne-allylic substitution of vinyl ethynylethylene carbonates towards a formal [3 + 3] cycloaddition DOI

Yu Bao,

Haihui Zhu,

Hai Huang

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155487 - 155487

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enantioselective Construction of Indolizines Containing Vicinal Diaxial Chirality DOI

Yongjian Yang,

Chuanyao Yang,

Xingcan Zhang

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 3442 - 3450

Published: Feb. 12, 2025

Language: Английский

Citations

0
Copper-Catalyzed Asymmetric Cloke–Wilson Rearrangement DOI

Jun-Han Yu,

Guo‐Qiang Lin,

Zhi‐Tao He

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Herein we describe the first transition-metal-catalyzed asymmetric Cloke-Wilson rearrangement through unprecedented propargylic alkenoxylation reaction with enol as O-nucleophile. A set of new chiral PPBOX ligands was prepared to guarantee high enantioselectivity transformation. series polysubstituted dihydrofuran skeletons bearing an alkyne unit in good yield and under very mild conditions, various downstream transformations were facilely conducted access different skeletons.

Language: Английский

Citations

0
Copper-catalyzed yne-allylic substitutions: concept and recent developments DOI Creative Commons
Shuang Yang, Xinqiang Fang

Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 2739 - 2775

Published: Oct. 31, 2024

The catalytic (asymmetric) allylation and propargylation have been established as powerful strategies allowing access to enantioenriched α-chiral alkenes alkynes. In this context, combining allylic propargylic substitutions offers new opportunities expand the scope of transition metal-catalyzed substitution reactions. Since its discovery in 2022, copper-catalyzed yne-allylic has undergone rapid development significant progress made using key copper vinyl allenylidene intermediates. This review summarizes developments illustrates influences salt, ligand, pattern substrate on regioselectivity stereoselectivity.

Language: Английский

Citations

1
Biaxially chiral compounds: research and development of synthesis DOI

Kongling Feng,

Chaochao Yao,

Hao Xu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

To date, two asymmetric catalytic methods have been established for the synthesis of biaxially chiral molecules: transition-metal-catalysis and organocatalysis.

Language: Английский

Citations

0