Similarities in B Cell Defects between Aging and Obesity DOI
Daniela Frasca, Maria Romero, Bonnie B. Blomberg

et al.

The Journal of Immunology, Journal Year: 2024, Volume and Issue: 213(10), P. 1407 - 1413

Published: Nov. 4, 2024

Abstract The aging population is increasing worldwide, and there also an increase in the living with overweight obesity, due to changes lifestyle dietary patterns that elderly individuals experience later life. Both obesity are conditions of accelerated metabolic dysfunction dysregulated immune responses. In this review, we summarize published findings showing induces humoral immunity similar those induced by age-associated B cell defects mainly changes. We discuss role obese adipose tissue inducing dysfunctional responses autoimmune Ab secretion.

Language: Английский

Lactate: A key regulator of the immune response DOI Creative Commons
Alba Llibre,

Salih Kucuk,

Atrayee Gope

et al.

Immunity, Journal Year: 2025, Volume and Issue: 58(3), P. 535 - 554

Published: March 1, 2025

SummaryLactate, the end product of both anaerobic and aerobic glycolysis in proliferating growing cells—with latter process known as Warburg effect—is historically considered a mere waste cell tissue metabolism. However, research over past ten years has unveiled multifaceted functions lactate that critically shape impact cellular biology. Beyond serving fuel source, is now to influence gene expression through histone modification function signaling molecule impacts wide range activities. These properties have been particularly studied context adaptive innate immune responses. Here, we review diverse roles regulation system during homeostasis disease pathogenesis (including cancer, infection, cardiovascular diseases, autoimmunity). Furthermore, describe recently proposed therapeutic interventions for manipulating metabolism human diseases.

Language: Английский

Citations

1
Lactylation-related molecular subtyping reveals the immune heterogeneity and clinical characteristics in ulcerative colitis DOI Creative Commons

Jinyang Zhai,

Runxi Fu,

Shangjian Luo

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 756, P. 151584 - 151584

Published: March 5, 2025

Language: Английский

Citations

0
Pain, lactate, and anesthetics: intertwined regulators of tumor metabolism and immunity DOI Creative Commons
Qing Lan, Aiping Ouyang, Yijian Chen

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 17, 2025

Patients with advanced cancer frequently endure severe pain, which substantially diminishes their quality of life and can adversely impact survival. Analgesia, a critical modality for alleviating such is now under scrutiny its potential role in progression, relationship whose underlying mechanisms remain obscure. Emerging evidence suggests that lactate, once considered metabolic byproduct, actively participates the malignant progression by modulating both immunological pathways within tumor microenvironment. Furthermore, lactate implicated modulation cancer-related exerting effects through direct indirect mechanisms. This review synthesizes current understanding lactate's production, transport, functional roles cells, encompassing regulation metabolism, immunity, progression. Additionally, we dissect complex, bidirectional between assess anesthetics on pain relief, homeostasis, tumorigenesis.

Language: Английский

Citations

0
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence DOI Creative Commons
Caiyu Sun, Jiaxuan Li, Lei Dong

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Cellular senescence is the basic unit of organismal aging, a complicated biological process involving several cell types and tissues. It also an important mechanism by which body responds to damage potential carcinogenesis. However, excessive or abnormal cellular can lead tissue functional degradation occurrence diseases. In recent years, role epigenetic modifications in has received extensive attention. Lactylation, novel post-translational modification derived from lactate, recently gained significant attention as key factor metabolism regulation, gradually demonstrating its importance regulation senescence. This review emphasizes bidirectional causal relationship between lactylation senescence, highlighting therapeutic target for aging-related

Language: Английский

Citations

0
Emerging roles of lysine lactyltransferases and lactylation DOI
Zhi Zong,

Jiang Ren,

Bing Yang

et al.

Nature Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
The role of hypoxic microenvironment in autoimmune diseases DOI Creative Commons
Xun Gong,

S. Yang,

Zhenyu Wang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the pathogenesis and progression of various autoimmune diseases (AIDs). Central to this process is hypoxia-inducible factor-1 (HIF-1), which orchestrates wide array cellular responses under low conditions. This review delves into multifaceted roles microenvironment modulating immune cell function, particularly highlighting its impact on activation, metabolic reprogramming, angiogenesis. Specific focus given mechanisms hypoxia contributes development exacerbation such rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), dermatomyositis (DM). In these conditions, not only disrupts tolerance but also enhances inflammatory promotes tissue damage. discusses emerging therapeutic strategies aimed at targeting pathways, including application HIF-1α inhibitors, mTOR other modulators response. By providing comprehensive overview interplay between dysfunction AIDs, offers new perspectives underlying highlights potential avenues for intervention.

Language: Английский

Citations

3
Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response DOI
José Luis García‐Gimenez, Irene Cánovas-Cervera, Elena Nácher-Sendra

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Adaptive immunity and metabolism DOI
Katherine Verbist, Piyush Sharma,

Helen M. Beere

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 157 - 190

Published: Jan. 1, 2025

Language: Английский

Citations

0
Immunometabolic Regulation of Vaccine-Induced Antibody Responses in Aging Mice DOI Creative Commons
Daniela Frasca, Maria Romero,

Laura Padula

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 960 - 960

Published: Aug. 26, 2024

Immune cells undergo metabolic reprogramming to meet the demands associated with immune responses. The effects of aging on these pathways and phenotype participating in antibody responses vaccines are still largely unknown. Here we used a vaccine for SARS-CoV-2 that utilizes cellular heat shock chaperone glycoprotein 96 (gp96), engineered co-express Spike (spike) protein (gp96-Ig-S). Results show this induces comparable B cell primary young old mice at later time points, but significantly lesser secondary response as compared mice, antibodies generated being also lower avidity. This occurs because changes hyper-metabolic higher intrinsic inflammation decreased protective However, gp96-Ig-S was found be effective reducing metabolic/inflammatory status from suggesting possibility targeting may improve function do not respond adequately vaccine.

Language: Английский

Citations

1
Similarities in B Cell Defects between Aging and Obesity DOI
Daniela Frasca, Maria Romero, Bonnie B. Blomberg

et al.

The Journal of Immunology, Journal Year: 2024, Volume and Issue: 213(10), P. 1407 - 1413

Published: Nov. 4, 2024

Abstract The aging population is increasing worldwide, and there also an increase in the living with overweight obesity, due to changes lifestyle dietary patterns that elderly individuals experience later life. Both obesity are conditions of accelerated metabolic dysfunction dysregulated immune responses. In this review, we summarize published findings showing induces humoral immunity similar those induced by age-associated B cell defects mainly changes. We discuss role obese adipose tissue inducing dysfunctional responses autoimmune Ab secretion.

Language: Английский

Citations

1