Lactate: A key regulator of the immune response
Alba Llibre,
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Salih Kucuk,
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Atrayee Gope
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et al.
Immunity,
Journal Year:
2025,
Volume and Issue:
58(3), P. 535 - 554
Published: March 1, 2025
SummaryLactate,
the
end
product
of
both
anaerobic
and
aerobic
glycolysis
in
proliferating
growing
cells—with
latter
process
known
as
Warburg
effect—is
historically
considered
a
mere
waste
cell
tissue
metabolism.
However,
research
over
past
ten
years
has
unveiled
multifaceted
functions
lactate
that
critically
shape
impact
cellular
biology.
Beyond
serving
fuel
source,
is
now
to
influence
gene
expression
through
histone
modification
function
signaling
molecule
impacts
wide
range
activities.
These
properties
have
been
particularly
studied
context
adaptive
innate
immune
responses.
Here,
we
review
diverse
roles
regulation
system
during
homeostasis
disease
pathogenesis
(including
cancer,
infection,
cardiovascular
diseases,
autoimmunity).
Furthermore,
describe
recently
proposed
therapeutic
interventions
for
manipulating
metabolism
human
diseases.
Language: Английский
Lactylation-related molecular subtyping reveals the immune heterogeneity and clinical characteristics in ulcerative colitis
Jinyang Zhai,
No information about this author
Runxi Fu,
No information about this author
Shangjian Luo
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et al.
Biochemical and Biophysical Research Communications,
Journal Year:
2025,
Volume and Issue:
756, P. 151584 - 151584
Published: March 5, 2025
Language: Английский
Pain, lactate, and anesthetics: intertwined regulators of tumor metabolism and immunity
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: March 17, 2025
Patients
with
advanced
cancer
frequently
endure
severe
pain,
which
substantially
diminishes
their
quality
of
life
and
can
adversely
impact
survival.
Analgesia,
a
critical
modality
for
alleviating
such
is
now
under
scrutiny
its
potential
role
in
progression,
relationship
whose
underlying
mechanisms
remain
obscure.
Emerging
evidence
suggests
that
lactate,
once
considered
metabolic
byproduct,
actively
participates
the
malignant
progression
by
modulating
both
immunological
pathways
within
tumor
microenvironment.
Furthermore,
lactate
implicated
modulation
cancer-related
exerting
effects
through
direct
indirect
mechanisms.
This
review
synthesizes
current
understanding
lactate's
production,
transport,
functional
roles
cells,
encompassing
regulation
metabolism,
immunity,
progression.
Additionally,
we
dissect
complex,
bidirectional
between
assess
anesthetics
on
pain
relief,
homeostasis,
tumorigenesis.
Language: Английский
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Cellular
senescence
is
the
basic
unit
of
organismal
aging,
a
complicated
biological
process
involving
several
cell
types
and
tissues.
It
also
an
important
mechanism
by
which
body
responds
to
damage
potential
carcinogenesis.
However,
excessive
or
abnormal
cellular
can
lead
tissue
functional
degradation
occurrence
diseases.
In
recent
years,
role
epigenetic
modifications
in
has
received
extensive
attention.
Lactylation,
novel
post-translational
modification
derived
from
lactate,
recently
gained
significant
attention
as
key
factor
metabolism
regulation,
gradually
demonstrating
its
importance
regulation
senescence.
This
review
emphasizes
bidirectional
causal
relationship
between
lactylation
senescence,
highlighting
therapeutic
target
for
aging-related
Language: Английский
Emerging roles of lysine lactyltransferases and lactylation
Zhi Zong,
No information about this author
Jiang Ren,
No information about this author
Bing Yang
No information about this author
et al.
Nature Cell Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Language: Английский
The role of hypoxic microenvironment in autoimmune diseases
Xun Gong,
No information about this author
S. Yang,
No information about this author
Zhenyu Wang
No information about this author
et al.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 7, 2024
The
hypoxic
microenvironment,
characterized
by
significantly
reduced
oxygen
levels
within
tissues,
has
emerged
as
a
critical
factor
in
the
pathogenesis
and
progression
of
various
autoimmune
diseases
(AIDs).
Central
to
this
process
is
hypoxia-inducible
factor-1
(HIF-1),
which
orchestrates
wide
array
cellular
responses
under
low
conditions.
This
review
delves
into
multifaceted
roles
microenvironment
modulating
immune
cell
function,
particularly
highlighting
its
impact
on
activation,
metabolic
reprogramming,
angiogenesis.
Specific
focus
given
mechanisms
hypoxia
contributes
development
exacerbation
such
rheumatoid
arthritis
(RA),
systemic
lupus
erythematosus
(SLE),
multiple
sclerosis
(MS),
dermatomyositis
(DM).
In
these
conditions,
not
only
disrupts
tolerance
but
also
enhances
inflammatory
promotes
tissue
damage.
discusses
emerging
therapeutic
strategies
aimed
at
targeting
pathways,
including
application
HIF-1α
inhibitors,
mTOR
other
modulators
response.
By
providing
comprehensive
overview
interplay
between
dysfunction
AIDs,
offers
new
perspectives
underlying
highlights
potential
avenues
for
intervention.
Language: Английский
Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response
Free Radical Biology and Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Language: Английский
Adaptive immunity and metabolism
Elsevier eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 157 - 190
Published: Jan. 1, 2025
Language: Английский
Immunometabolic Regulation of Vaccine-Induced Antibody Responses in Aging Mice
Daniela Frasca,
No information about this author
Maria Romero,
No information about this author
Laura Padula
No information about this author
et al.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 960 - 960
Published: Aug. 26, 2024
Immune
cells
undergo
metabolic
reprogramming
to
meet
the
demands
associated
with
immune
responses.
The
effects
of
aging
on
these
pathways
and
phenotype
participating
in
antibody
responses
vaccines
are
still
largely
unknown.
Here
we
used
a
vaccine
for
SARS-CoV-2
that
utilizes
cellular
heat
shock
chaperone
glycoprotein
96
(gp96),
engineered
co-express
Spike
(spike)
protein
(gp96-Ig-S).
Results
show
this
induces
comparable
B
cell
primary
young
old
mice
at
later
time
points,
but
significantly
lesser
secondary
response
as
compared
mice,
antibodies
generated
being
also
lower
avidity.
This
occurs
because
changes
hyper-metabolic
higher
intrinsic
inflammation
decreased
protective
However,
gp96-Ig-S
was
found
be
effective
reducing
metabolic/inflammatory
status
from
suggesting
possibility
targeting
may
improve
function
do
not
respond
adequately
vaccine.
Language: Английский
Similarities in B Cell Defects between Aging and Obesity
The Journal of Immunology,
Journal Year:
2024,
Volume and Issue:
213(10), P. 1407 - 1413
Published: Nov. 4, 2024
Abstract
The
aging
population
is
increasing
worldwide,
and
there
also
an
increase
in
the
living
with
overweight
obesity,
due
to
changes
lifestyle
dietary
patterns
that
elderly
individuals
experience
later
life.
Both
obesity
are
conditions
of
accelerated
metabolic
dysfunction
dysregulated
immune
responses.
In
this
review,
we
summarize
published
findings
showing
induces
humoral
immunity
similar
those
induced
by
age-associated
B
cell
defects
mainly
changes.
We
discuss
role
obese
adipose
tissue
inducing
dysfunctional
responses
autoimmune
Ab
secretion.
Language: Английский