Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex DOI Creative Commons
Keisuke Sehara, Masashi Kondo,

Yuka Hirayama

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective whether movements are task-relevant or task-irrelevant. To examine extent to which a primitive cognitive signal, i.e., reward expectancy, modulate multiple cortical areas in primates, we conducted unprecedented wide-field one-photon calcium imaging frontoparietal auditory cortices common marmosets while they performed classical conditioning task with two cues associated different probabilities. Licking, eye movement, hand movement strongly modulated neuronal after cue presentation motor somatosensory accordance somatotopy. By contrast, posterior parietal cortex primary did not show much influence from licking. Licking increased caudal part premotor cortex, but decreased central lateral parts rostral (PMdr). Reward expectancy that was separable both spontaneous goal-directed mainly represented medial PMdr. Our results suggest on primate varies types, processes information ways within further subdivided areas.

Language: Английский

ARViS: a bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex DOI Creative Commons

Shinnosuke Nomura,

Shin-Ichiro Terada, Teppei Ebina

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 10, 2024

Language: Английский

Citations

0
3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking DOI Creative Commons
Victoria B Hosack, Fritzie I. Arce‐McShane

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 4, 2024

Directional tongue movements are essential for vital behaviors, such as feeding and speech, to position food chewing swallowing safely the accurate sound production. While directional tuning has been well-studied in arm region of sensorimotor cortex during reaching tasks, little is known about how 3D direction encoded orofacial natural behaviors. Understanding represented brain important implications improving rehabilitation people with orolingual dysfunctions. The goal this study investigate movement (OSMCx) drinking, process affected by loss oral sensation. Using biplanar video-radiography track implanted markers behaving non-human primates (Macaca mulatta), positional data was recorded simultaneously spiking activity primary motor (MIo) somatosensory (SIo) areas using chronically microelectrode arrays. In some sessions, tasks were preceded bilateral nerve block injections sensory branches trigeminal nerve. Modulation found a majority MIo but not SIo neurons feeding, while both modulated protrusion drinking. Following loss, proportion directionally tuned decreased shifts distribution preferred observed OSMCx neurons. Overall, we show that varies behavioral availability information.

Language: Английский

Citations

0
Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex DOI Creative Commons
Keisuke Sehara, Masashi Kondo,

Yuka Hirayama

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective whether movements are task-relevant or task-irrelevant. To examine extent to which a primitive cognitive signal, i.e., reward expectancy, modulate multiple cortical areas in primates, we conducted unprecedented wide-field one-photon calcium imaging frontoparietal auditory cortices common marmosets while they performed classical conditioning task with two cues associated different probabilities. Licking, eye movement, hand movement strongly modulated neuronal after cue presentation motor somatosensory accordance somatotopy. By contrast, posterior parietal cortex primary did not show much influence from licking. Licking increased caudal part premotor cortex, but decreased central lateral parts rostral (PMdr). Reward expectancy that was separable both spontaneous goal-directed mainly represented medial PMdr. Our results suggest on primate varies types, processes information ways within further subdivided areas.

Language: Английский

Citations

0