Human Brain-Wide Activation of Sleep Rhythms

Published: Feb. 17, 2025

During sleep, our brain undergoes highly synchronized activity, orchestrated by distinct neural rhythms. Little is known about the associated activation during these sleep rhythms, and even less their functional implications. In this study, we investigated brain-wide underlying human rhythms employing simultaneous electroencephalography (EEG) magnetic resonance imaging (fMRI) in 107 participants overnight sleep. We identified a significant coupling between slow oscillations (SO) spindle events non-rapid eye movement (NREM) particularly at UP-state of SOs. This was with increased thalamus hippocampus, showing that resembles episodic memory processing, yet distinctly dissociated from task-related activation. Moreover, SO-spindle linked to selective increase connectivity hippocampus thalamus, neocortex, medial prefrontal cortex. These findings suggest plays crucial role coordinating hippocampal-cortical dialogue

Language: Английский

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Human Brain-Wide Activation of Sleep Rhythms

Published: Feb. 17, 2025

During sleep, our brain undergoes highly synchronized activity, orchestrated by distinct neural rhythms. Little is known about the associated activation during these sleep rhythms, and even less their functional implications. In this study, we investigated brain-wide underlying human rhythms employing simultaneous electroencephalography (EEG) magnetic resonance imaging (fMRI) in 107 participants overnight sleep. We identified a significant coupling between slow oscillations (SO) spindle events non-rapid eye movement (NREM) particularly at UP-state of SOs. This was with increased thalamus hippocampus, showing that resembles episodic memory processing, yet distinctly dissociated from task-related activation. Moreover, SO-spindle linked to selective increase connectivity hippocampus thalamus, neocortex, medial prefrontal cortex. These findings suggest plays crucial role coordinating hippocampal-cortical dialogue

Language: Английский

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Sleep studies enter the real world

Nature Human Behaviour, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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The predictive nature of spontaneous brain activity across scales and species

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Time-dependent consolidation mechanisms of durable memory in spaced learning

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 1, 2025

Language: Английский

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Linking visual-frontoparietal network neural dynamics to spontaneous cognitive processing

NeuroImage, Journal Year: 2025, Volume and Issue: 312, P. 121229 - 121229

Published: April 26, 2025

Previous studies in neuroscience have predominantly focused on the role of default mode network (DMN) spontaneous thought, with contributions other brain regions remaining largely unexplored. In this study, we hypothesized that visual-frontoparietal (VFPN) would exhibit distinct macroscopic patterns associated cognitive processing. To test hypothesis, analyzed four functional magnetic resonance imaging (fMRI) datasets. Our results revealed self-reported states during rest were strongly correlated specific VFPN. These also observed movie viewing/listening and had previously been identified multistable perception tasks. Further analysis showed microscopic activation visual areas closely linked to states. Additionally, found memory replay was more pronounced when frontoparietal active, compared it inactive. Finally, fluctuations VFPN their coupling hippocampus significant predictors offline enhancement. conclusion, these findings demonstrate consistent resting are activity, providing strong evidence for roles beyond DMN thought.

Language: Английский

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Awake reactivation of cortical memory traces predicts subsequent memory retrieval

Progress in Neurobiology, Journal Year: 2025, Volume and Issue: unknown, P. 102778 - 102778

Published: May 1, 2025

Language: Английский

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Distributed Patterns of Functional Connectivity Underlie Individual Differences in Long-Term Memory Forgetting

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: Aug. 5, 2021

Abstract Despite the importance of memories in everyday life and progress made understanding how they are encoded retrieved, neural processes by which declarative maintained or forgotten remain elusive. Part problem is that it empirically difficult to measure rate at fade, even between repeated presentations source memory. Without such a ground-truth measure, hard identify corresponding correlates. This study addresses this comparing individual patterns functional connectivity against behavioral differences forgetting speed derived from computational phenotyping. Specifically, individual-specific values long-term memory (LTM) were estimated for 33 participants using formal model fit accuracy response time data an adaptive fact learning task. Individual speeds then used examine participant-specific resting-state fMRI connectivity, machine techniques most predictive generalizable features. Our results show associated with within default mode network (DMN) as well DMN cortical sensory areas. Cross-validation showed predicted high ( r = .78) these alone. These support view activity regions actively involved maintaining preventing their decline, suggesting better understood result storage decay, rather than retrieval failure.

Language: Английский

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Human Brain-Wide Activation of Sleep Rhythms

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract During sleep, our brain undergoes highly synchronized activity, orchestrated by distinct neural rhythms. Little is known about the associated activation during these sleep rhythms, and even less their functional implications. In this study, we investigated brain-wide underlying human rhythms employing simultaneous electroencephalography (EEG) magnetic resonance imaging (fMRI) in 107 participants overnight sleep. We identified a significant coupling between slow oscillations (SO) spindle events non-rapid eye movement (NREM) particularly at UP-state of SOs. This was with increased thalamus hippocampus, showing that resembles episodic memory processing, yet distinctly dissociated from task-related activation. Moreover, SO-spindle linked to selective increase connectivity hippocampus thalamus, neocortex, medial prefrontal cortex. These findings suggest plays crucial role coordinating hippocampal-cortical dialogue

Language: Английский

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Intact ultrafast memory consolidation in adults with autism and neurotypicals with autism traits

Brain Research, Journal Year: 2024, Volume and Issue: 1847, P. 149299 - 149299

Published: Oct. 31, 2024

The processes of learning and memory consolidation are closely interlinked. Therefore, to uncover statistical in autism spectrum disorder (ASD), an in-depth examination is essential. Studies the last five years have revealed that can take place not only during practice but also micro rest (<1 min) between blocks, termed offline gains. concept gains refers performance improvements short periods interspersed with practice, rather than itself. This phenomenon crucial for acquisition motor skills has been observed across various contexts. Numerous studies on identified intact there no investigation into this fundamental aspect autistic individuals date. We conducted two different samples: 1) neurotypical adults distinct levels traits (N = 166) 2) ASD-diagnosed (NASD 22, NNTP 20). Participants performed a well-established probabilistic task, allowing us measure separately same experimental design: (i.e., probability-based regularities) visuomotor speed-up regardless probabilities). Here we show considerable individual differences (between blocks) changes between-blocks improvement performance. However, cumulative evidence from suggests degree ASD status associated gains, indicating that, like learning, rapid intact.

Language: Английский

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