ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(11), P. 6207 - 6217
Published: Nov. 6, 2024
Highly
selective
and
sensitive
in
vivo
neurotransmitter
dynamic
monitoring
of
the
central
nervous
system
has
long
been
a
challenging
endeavor.
Here,
an
implantable
biocompatible
microsensor
with
excellent
performances
was
reported
by
electrodepositing
poly(3,4-ethylenedioxythiophene)-electrochemically
reduced
graphene
oxide
(PEDOT-ERGO)
nanocomposites
poly(tannic
acid)
(pTA)
sequentially
on
carbon
fiber
electrode
(CFE)
surface,
its
feasibility
electrochemical
sensing
applications
were
demonstrated.
Due
to
synergistic
electrocatalytic
effect
PEDOT-ERGO
negative-charged
pTA
dopamine
(DA)
redox
reaction,
exhibits
high
detection
sensitivities
1.1
0.37
nA
μM
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
In
vivo
electrochemical
sensing
of
neurotransmitters,
neuromodulators,
and
metabolites
plays
a
critical
role
in
real-time
monitoring
various
physiological
or
psychological
processes
the
central
nervous
system.
Currently,
advanced
biosensors
technologies
have
been
emerging
as
prominent
ways
to
meet
surging
requirements
neurotransmitters
neuromodulators
ranging
from
single
cells
brain
slices,
even
entire
brain.
This
review
introduces
fundamental
working
principles
summarizes
achievements
biosensing
including
voltammetry,
amperometry,
potentiometry,
field-effect
transistor
(FET),
organic
(OECT).
According
elaborate
feature
technology,
versatile
strategies
devoted
solve
issues
associated
with
neurochemicals
under
an
intricate
environment.
Voltammetry
is
universal
technique
investigate
complex
matrices
which
could
realize
miniaturization
electrodes,
while
amperometry
serves
well-suited
approach
offering
high
temporal
resolution
favorable
for
fast
oxidation–reduction
kinetics
neurochemicals.
Potentiometry
realizes
quantitative
analysis
by
recording
potential
difference
reduced
invasiveness
compatibility.
FET
OECT
serve
amplification
higher
sensitivity
than
traditional
technologies.
Furthermore,
we
point
out
current
shortcomings
address
challenges
perspectives
iScience,
Journal Year:
2025,
Volume and Issue:
28(2), P. 111763 - 111763
Published: Jan. 7, 2025
Recent
years
have
witnessed
tremendous
advances
in
wearable
sensors,
which
play
an
essential
role
personalized
healthcare
for
their
ability
real-time
sensing
and
detection
of
human
health
information.
Nanozymes,
capable
mimicking
the
functions
natural
enzymes
addressing
limitations,
possess
unique
advantages
such
as
structural
stability,
low
cost,
ease
mass
production,
making
them
particularly
beneficial
constructing
recognition
units
biosensors.
In
this
review,
we
aim
to
delineate
latest
advancements
nanozymes
development
biosensors,
focusing
on
key
developments
nanozyme
immobilization
strategies,
technologies,
biomedical
applications.
The
review
also
highlights
current
challenges
future
perspectives.
Ultimately,
it
aims
provide
insights
research
endeavors
rapidly
evolving
area.
Angewandte Chemie International Edition,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Abstract
Nanozymes
with
atomically
dispersed
metal
sites
(ADzymes),
especially
single‐atom
nanozymes,
have
attracted
widespread
attention
in
recent
years
due
to
their
unique
advantages
mimicking
the
active
of
natural
enzymes.
These
nanozymes
not
only
maximize
exposure
catalytic
but
also
possess
superior
activity
performance,
achieving
challenging
reactions.
position
ADzymes
as
highly
promising
candidates
field
sensing
and
biosensing.
This
review
summarizes
classification
properties
ADzymes,
systematically
highlighting
some
typical
regulation
strategies
involving
central
metal,
coordination
environment,
etc.,
achieve
catalytical
activity,
specificity,
multifunctionality.
Then,
we
present
advances
different
fields,
including
colorimetry,
fluorescence,
electrochemistry,
chemiluminescence,
photoelectrochemistry,
electrochemiluminescence.
Taking
advantage
resultant
show
great
potential
goal
sensitivity,
selectivity
accuracy
for
detection
various
targets.
Specifically,
underlying
mechanisms
terms
signal
amplification
were
discussed
detail.
Finally,
current
challenges
perspectives
on
development
advanced
are
discussed.
Angewandte Chemie,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Abstract
Nanozymes
with
atomically
dispersed
metal
sites
(ADzymes),
especially
single‐atom
nanozymes,
have
attracted
widespread
attention
in
recent
years
due
to
their
unique
advantages
mimicking
the
active
of
natural
enzymes.
These
nanozymes
not
only
maximize
exposure
catalytic
but
also
possess
superior
activity
performance,
achieving
challenging
reactions.
position
ADzymes
as
highly
promising
candidates
field
sensing
and
biosensing.
This
review
summarizes
classification
properties
ADzymes,
systematically
highlighting
some
typical
regulation
strategies
involving
central
metal,
coordination
environment,
etc.,
achieve
catalytical
activity,
specificity,
multifunctionality.
Then,
we
present
advances
different
fields,
including
colorimetry,
fluorescence,
electrochemistry,
chemiluminescence,
photoelectrochemistry,
electrochemiluminescence.
Taking
advantage
resultant
show
great
potential
goal
sensitivity,
selectivity
accuracy
for
detection
various
targets.
Specifically,
underlying
mechanisms
terms
signal
amplification
were
discussed
detail.
Finally,
current
challenges
perspectives
on
development
advanced
are
discussed.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Neural
interfacing
technologies,
combined
with
biospecific
targeting
and
neuroelectrochemical
analysis,
provide
a
powerful
platform
for
advancing
the
understanding
of
neural
communication
at
single-cell
level.
A
key
factor
in
this
integration
is
role
protein-mediated
cell
adhesion
cell-electrode
interface,
which
can
influence
cellular
processes
such
as
exocytosis.
However,
specific
impact
interaction
remains
largely
unexplored.
In
study,
electrode
functionalized
genetically
engineered
neuroligin-2
(eNLG2)
developed
its
effect
on
exocytosis
PC12
cells
investigated.
The
findings
reveal
that
eNLG2-modified
electrodes
significantly
slowed
kinetics
increased
amount
neurotransmitters
released
per
event
compared
to
non-protein-modified
laminin-modified
electrodes.
These
results
suggest
synaptic
membrane
proteins,
neuroligin
neurexin,
modulate
vesicle
fusion
dynamics
likely
by
influencing
properties
intracellular
signaling.
This
study
highlights
potential
combining
technologies
approaches
gain
comprehensive
insights
into
communication.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(42), P. 16499 - 16504
Published: Oct. 9, 2024
Accurate
diagnosis
of
highly
aggressive
and
deadly
tumors
is
essential
for
effective
treatment
improved
patient
outcomes,
microRNAs
(miRNAs)
have
emerged
as
crucial
biomarkers
their
roles
in
tumor
initiation,
progression,
metastasis.
Herein,
we
present
an
on-site
visualization
colorimetric
assay
tumor-associated
miRNAs
using
ruthenium
nanoparticle
decorated
titanium
dioxide
nanoribbon
(Ru@TiO
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 27, 2025
Abstract
Metal–organic
frameworks
(MOFs)
are
widely
used
as
substrates
for
creating
single‐atom
catalysts
due
to
their
abundance
of
ligands,
facilitating
enzyme‐like
activity
biomedical
applications.
However,
the
high‐temperature
calcination
process
limits
economical,
efficient,
and
large‐scale
synthesis.
Here,
a
simple
room‐temperature
synthesis
MOF‐based
metal
cluster
is
presented
tumor
therapy.
Fe/MOF
obtained
through
coordination
reaction
at
room
temperature,
while
Au/MOF
synthesized
from
Au
3+
/MOF
by
introducing
reducing
agent.
effectively
generates
hydrogen
peroxide
(H
2
O
)
glucose,
outperforming
/MOF,
subsequently
produced
hydroxyl
radicals
(•OH)
decomposing
generated
H
via
accelerated
peroxidase‐like
in
an
acidic
environment.
In
vitro
vivo
studies
confirm
significantly
enhanced
cancer
eradication
ability
compared
PBS‐treated
group
combining
cascade
enzymatic
activity,
destruction
oxidative
homeostasis,
excessive
mitochondrial‐mediated
lipid
peroxidation.
The
novel
establishes
new
paradigm
fabricating
effective
nanomaterials
multimodal
