Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers DOI Creative Commons
Muhammad Naveed,

Zhaokang Shen,

Jianqiang Bao

et al.

Cell & Bioscience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Over the past two decades, study of sperm-borne small non-coding RNAs (sncRNAs) has garnered substantial growth. Once considered mere byproducts during germ cell maturation, these sncRNAs have now been recognized as crucial carriers epigenetic information, playing a significant role in transmitting acquired traits from paternal to offspring, particularly under environmental influences. A growing body evidence highlights pivotal facilitating inheritance across generations. However, exact mechanisms through which paternally supplied operate remain unclear and are hot debate. This concise review presents most extensive date on environmentally-responsive sncRNAs, encompassing brief summary their origin, dynamics, compartmentalization, characteristics, well in-depth elaboration functional roles transgenerational inheritance. Additionally, delves into potential by sperm-delivered may acquire transmit modulating zygotic gene expression influencing early embryonic development.

Language: Английский

Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers DOI Creative Commons
Muhammad Naveed,

Zhaokang Shen,

Jianqiang Bao

et al.

Cell & Bioscience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Over the past two decades, study of sperm-borne small non-coding RNAs (sncRNAs) has garnered substantial growth. Once considered mere byproducts during germ cell maturation, these sncRNAs have now been recognized as crucial carriers epigenetic information, playing a significant role in transmitting acquired traits from paternal to offspring, particularly under environmental influences. A growing body evidence highlights pivotal facilitating inheritance across generations. However, exact mechanisms through which paternally supplied operate remain unclear and are hot debate. This concise review presents most extensive date on environmentally-responsive sncRNAs, encompassing brief summary their origin, dynamics, compartmentalization, characteristics, well in-depth elaboration functional roles transgenerational inheritance. Additionally, delves into potential by sperm-delivered may acquire transmit modulating zygotic gene expression influencing early embryonic development.

Language: Английский

Citations

0