Oral delivery of probiotic combined natural phenolic-metal framework with microencapsulation for prolonged intestinal retention and alleviation of inflammatory bowel disease

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162763 - 162763

Published: April 1, 2025

Language: Английский

A Polysaccharide Metal Phenolic Network Nanocomposite for Theranostic Applications in Inflammatory Bowel Disease

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract Nanotechnology has significantly facilitated the diagnosis and therapy of inflammatory bowel disease (IBD). To obtain better therapeutic efficacy, a nanoplatform built from polysaccharides metal‐phenolic networks (MPN) is developed here to enhance retention in damaged intestinal region modulate systemic immunological status IBD models. Polysaccharides tragacanth gum (GUM) are coordinated with iron further interact shikonin (Shik) nanocomposite named Shik‐Fe@GUM. Shik‐Fe@GUM demonstrates strong persistent accumulation inflamed region, which validated clinical specimens patients, cocultured cellular models, living animals. served as scavenger for reactive oxygen or nitrogen species tissues cells, alleviated local by cytokine downregulation. In addition, restored functions colonic barriers mitigate activity index. The working mechanisms also explored genetic sequencing results revealed that imposed its treatment effect attenuating major pathways. particular, can IL‐17RA relevant cell signaling reduce recruitment T h 17 cells (T helper 17). This polysaccharide‐metal‐functional molecule hybrid strategy be broadly applicable other drugs their index patients.

Language: Английский

Nanometabolomics elucidated oral Mo2C nanozyme-based therapy towards sleep deprivation-induced intestinal metabolic disorders via the regulation of ROS-related metabolism

Carbon, Journal Year: 2024, Volume and Issue: 233, P. 119913 - 119913

Published: Dec. 12, 2024

Language: Английский