Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111299 - 111299
Published: May 1, 2025
Language: Английский
Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41380 - e41380
Published: Jan. 1, 2025
Accumulating studies have highlighted the biological significance of immunogenic cell death (ICD) in cancer immunity. However, influence ICD on tumor microenvironment (TME) formation and immune response Hepatocellular carcinoma (HCC) remains largely unexplored. In this study, we systematically analyzed mRNA profiles ICD-related genes 1847 HCC patients identified three molecular subtypes with significantly different features prognostic stratification. A reliable risk model named score was constructed via machine learning algorithms to assess immunological status, therapeutic responses, clinical outcomes individual patients. High indicated an immune-excluded TME phenotype, lower anticancer immunity shorter survival time. contrast, low corresponded abundant infiltration, high sensitivity immunotherapy a positive prognosis, indicating "immune-hot" phenotype. Pan-cancer analysis further validated negative association between infiltration levels. conclusion, our findings revealed that could serve as robust biomarker predict benefits optimize decision-making
Language: Английский
Citations
0
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 730 - 740
Published: Jan. 27, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Developing effective radiotherapy is impeded by tumor radioresistance, imprecise treatment, and the need for accurate imaging. Herein, a multifunctional gadolinium-based nanoprobe (GBD) presented, integrating bioorthogonal click chemistry theranostics to enhance retention, magnetic resonance imaging (MRI) contrast, radiosensitivity. GBD synthesis involved biomimetic mineralization of bovine serum albumin (BSA) with gadolinium ions form nanoparticles (GB), followed conjugation dibenzocyclooctyne (DBCO). The optimized exhibited an elevated longitudinal relaxivity (r1) 25.54 mM-1 s-1, which represented 6.7-fold enhancement compared clinical MRI contrast agent magnevist (Gd-DTPA, 3.81 s-1). Notably, application enhanced affinity retention within cells modified express azide as artificial receptor. This novel strategy up 16 days postinjection, outperforming DBCO-modified small molecule (Gd-DBCO) less than 1-day retention. Such prolonged facilitated continuous radiosensitization throughout course, negating multiple injections, substantially boosted effectiveness radiotherapy. study demonstrates transformative potential combining nanotechnology in radiotherapy, offering precise targeting platform, real-time monitoring, improved treatment outcomes.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Inspired by the clinical application of thermotherapy to promote efficacy radiotherapy, this study demonstrates multimodal diagnostic pure organic nanoparticles in combined treatment tumors through imaging and photothermal properties. The developed demonstrated unique properties multiple functionalities, including excellent photostability thermostability, strong fluorescence emission near-infrared-II (NIR-II) region, extremely high conversion efficiency, good biocompatibility, significant radiosensitizing properties, effective tumor site accumulation. In vitro vivo evaluations that these are ideal candidates for synergistic radiotherapy guided NIR-II fluorescence, NIR-I photoacoustic, trimodal imaging. They act as radiosensitizers alleviating hypoxic microenvironment, modulating cell cycle, inducing apoptosis immunogenic death during which may provide a potential approach tumors.
Language: Английский
Citations
0
Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6
Published: April 10, 2025
Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body's immune system to fight cancer. Despite initial successes, its broader clinical application hindered by limitations such as heterogeneity in patient response challenges associated with tumor microenvironment. Recent advancements nanotechnology have offered innovative solutions these barriers, providing enhancements immunotherapy. Nanotechnology-based approaches exhibit multifaceted mechanisms, including effective anti-tumor responses during tumorigenesis overcoming suppression mechanisms improve defense capacity. Nanomedicines, nanoparticle-based vaccines, liposomes, modulators, gene delivery systems, demonstrated ability activate responses, modulate microenvironments, target specific cells. Success metrics preclinical early studies, improved survival rates, enhanced regression, elevated activation indices, highlight promise of technologies. achievements, several remain, scaling up manufacturing, addressing off-target effects, navigating regulatory complexities. The review emphasizes need for interdisciplinary address ensuring adoption. It also provides insights into approaches, advancements, transformative potential nano-immunotherapy promising results checkpoint inhibitor delivery, nanoparticle-mediated photothermal therapy, immunomodulation well inhibition nanoparticles vaccines.
Language: Английский
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0
Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111299 - 111299
Published: May 1, 2025
Language: Английский
Citations
0