Twists, turns and jumps: T6SS evolution within species

Trends in Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The type VI secretion system mediates interbacterial antagonism between Gram-negative bacteria through delivery of toxic effector proteins. A recent comprehensive genomic analysis by Habich et al. reveals interesting features the evolution T6SSs and their corresponding effectors in Pseudomonas aeruginosa, raising questions about functional specialization system.

Language: Английский

Transcriptome Sequencing Reveals Survival Strategies and Pathogenic Potential of Vibrio parahaemolyticus Under Gastric Acid Stress

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 396 - 396

Published: April 10, 2025

As a common food-borne pathogen, Vibrio parahaemolyticus comes into direct or indirect contact with gastric acid after ingestion. However, the mechanisms by which passes through barrier, recovers, and causes pathogenicity remain unclear. In this study, static in vitro digestion simulation experiments showed that some strains can pass barrier utilizing microacid tolerance altering their survival state. Food food matrices could help bacteria escape stress, significantly different rates observed for various exposure to acid. Interestingly, surviving shorter growth lag time (LT) during recovery. Transcriptome sequencing (RNA-seq) analyses indicated adapted stress regulating two-component system proteins secreted via ribosomal pathway. Pathogenic successfully potentially exhibits enhanced recovery due significant upregulation of virulence genes such as tdh yscF. This study provides scientific basis revealing pathogens represented human body.

Language: Английский

The road less traveled: Unexplored targets in the quest for antibiotics against Pseudomonas aeruginosa

Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108621 - 108621

Published: June 1, 2025

Language: Английский