Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 487 - 487
Published: March 26, 2025
Immunity is a fundamental aspect of animal biology, defined as the host's ability to detect and defend against harmful pathogens toxic substances preserve homeostasis. However, immune defenses are metabolically demanding, requiring efficient allocation limited resources balance function with other physiological developmental needs. To achieve this balance, organisms have evolved sophisticated signaling networks that enable precise, context-specific responses internal external cues. These essential for survival adaptation in multicellular systems. Central regulatory architecture STAT (signal transducer activator Transcription) family, group versatile molecules govern wide array biological processes across eukaryotes. demonstrates remarkable plasticity, from orchestrating host defense mechanisms regulating dietary metabolism. Despite its critical role, cell-specific context-dependent nuances remain incompletely understood, highlighting significant gap our understanding. This review delves into emerging perspectives on immunity, presenting dynamic frameworks explore complexity adaptability underlying logic driving cellular decision-making. It emphasizes how pathways integrate diverse processes, regulation, ultimately supporting organismal
Language: Английский