Microplastics exposure causes premature ovarian aging via inducing mitochondrial dysfunction DOI
Xing Duan,

Li‐Shu Li,

Wen-Jiao Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Ovarian aging represents a significant risk factor for female infertility, primarily due to decline in ovarian reserve and diminished oocyte quality. However, whether microplastics (MPs) exposure poses potential inducing the underlying mechanisms remain poorly understood. In this study, we demonstrated that MPs accelerates aging, characterized by elevated expression of senescence markers (p16 p21) increased fibrosis. Mechanistic analysis indicated led inflammatory damage mitochondrial dysfunction, which contribute reduced reserve. Furthermore, compromised maturation competence embryo development triggering dysfunction DNA damage. Multi-omics identified L-arginine as crucial metabolite protects oocytes from MPs-induced aging. Notably, supplementation significantly mitigated phenotypes induced MPs, evidenced fibrosis, damage, alongside enhanced These findings provide theoretical support reproductive protection against inform environmental assessments.

Language: Английский

Comparative analysis of human and mouse ovaries across age DOI Creative Commons
Eliza A. Gaylord, Mariko H. Foecke, Ryan M. Samuel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Mouse is a tractable model for human ovarian biology, however its utility limited by incomplete understanding of how transcription and signaling differ interspecifically with age. We compared ovaries between species using 3D-imaging, single-cell transcriptomics, functional studies. In mice, we mapped declining follicle numbers oocyte competence during aging; in ovaries, identified cortical pockets density changes. Oocytes had species-specific gene expression patterns growth that converged toward maturity. Age-related transcriptional changes were greater oocytes than granulosa cells across species, although mature change more humans. sympathetic nerves glia; nerve increased aged and, when ablated perturbed folliculogenesis. This comparative atlas defines shared hallmarks biology.

Language: Английский

Citations

0
The Mechanism by Which Estrogen Level Affects Knee Osteoarthritis Pain in Perimenopause and Non-Pharmacological Measures DOI Open Access
Huiying Zhao,

Yu Fan,

Wei Wu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2391 - 2391

Published: March 7, 2025

Perimenopausal women have fluctuating estrogen levels, which often trigger a range of symptoms perimenopausal syndromes as levels decrease. Changes in are closely related to pain knee osteoarthritis (KOA), has long been research area great interest women. In recent years, it found that an important role KOA pain, namely, can affect through the regulation inflammatory responses, inhibition cellular senescence and apoptosis, modulation neurotransmitters, may provide new ideas for treatment. This study aims describe mechanism level on perimenopause non-pharmacological measures, such physical therapy, factor traditional Chinese medicine, diet, reference treatment with KOA.

Language: Английский

Citations

0
Ovarian vascular aging: a hidden driver of mid-age female fertility decline DOI Creative Commons
Ge Wang,

Ruihua Yang,

Hua Zhang

et al.

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 30, 2025

Although ovarian reserve remains sufficient, function declines in mid-age, leading to reduced fertility around age 35, with the causes remaining unclear. Recent studies highlight vascular aging as a key factor this decline, age-related reductions remodeling disrupting oocyte development. Salidroside, natural compound that reverses and promotes angiogenesis, presents promising strategy rejuvenate health enhance fertility, offering potential for preserving reproductive aged women.

Language: Английский

Citations

0
Microplastics exposure causes premature ovarian aging via inducing mitochondrial dysfunction DOI
Xing Duan,

Li‐Shu Li,

Wen-Jiao Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Ovarian aging represents a significant risk factor for female infertility, primarily due to decline in ovarian reserve and diminished oocyte quality. However, whether microplastics (MPs) exposure poses potential inducing the underlying mechanisms remain poorly understood. In this study, we demonstrated that MPs accelerates aging, characterized by elevated expression of senescence markers (p16 p21) increased fibrosis. Mechanistic analysis indicated led inflammatory damage mitochondrial dysfunction, which contribute reduced reserve. Furthermore, compromised maturation competence embryo development triggering dysfunction DNA damage. Multi-omics identified L-arginine as crucial metabolite protects oocytes from MPs-induced aging. Notably, supplementation significantly mitigated phenotypes induced MPs, evidenced fibrosis, damage, alongside enhanced These findings provide theoretical support reproductive protection against inform environmental assessments.

Language: Английский

Citations

0