Benchmarking of Single Nuclei Rna-Seq Methods on Human Post-Mortem Brain Tissue DOI
Kasra Nikouei,

Elin Gruyters,

Fatima Memic

et al.

Published: Jan. 1, 2025

Language: Английский

Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes DOI Creative Commons
Jet D. Termorshuizen, Helena L. Davies, Susan J. Lee

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Eating disorders -including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder-are clinically distinct but exhibit symptom overlap diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first genomic meta-analysis of behaviour (BE; 39,279 cases, 1,227,436 controls), alongside new AN (24,223 1,243,971 controls) its subtypes (all European ancestries). identified six loci associated with BE, including higher body mass index (BMI) impulse-control behaviours. GWAS yielded eight loci, validating loci. Subsequent polygenic risk score analysis demonstrated an association in two East Asian ancestry cohorts. BE exhibited similar positive genetic correlations psychiatric disorders, opposing anthropometric traits. Most signal was not shared BMI. extended disorder genomics beyond AN; future work will incorporate multiple diagnoses global ancestries.

Language: Английский

Citations

0
BRAPH 2: a flexible, open-source, reproducible, community-oriented, easy-to-use framework for network analyses in neurosciences DOI
Yu-Wei Chang, Blanca Zufiria Gerbolés,

Emiliano Gómez-Ruiz

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

As network analyses in neuroscience continue to grow both complexity and size, flexible methods are urgently needed provide unbiased, reproducible insights into brain function. BRAPH 2 is a versatile, open-source framework that meets this challenge by offering streamlined workflows for advanced statistical models deep learning community-oriented environment. Through its Genesis compiler, users can build specialized distributions with custom pipelines, ensuring flexibility scalability across diverse research domains. These powerful capabilities will ensure reproducibility accelerate discoveries neuroscience.

Language: Английский

Citations

0
Genomics of schizophrenia, bipolar disorder and major depressive disorder DOI
Michael J. Owen, Nicholas J. Bray, James Walters

et al.

Nature Reviews Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Language: Английский

Citations

0
Benchmarking of Single Nuclei Rna-Seq Methods on Human Post-Mortem Brain Tissue DOI
Kasra Nikouei,

Elin Gruyters,

Fatima Memic

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0