The Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Open Access
Diren Beyoğlu, Jeffrey R. Idle

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2882 - 2882

Published: March 22, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition wherein excessive fat accumulates in the liver, leading to inflammation and potential damage. In this narrative review, we evaluate tissue microbiota, how they arise their constituent microbes, role of intestinal hepatic microbiota MASLD. The history bacteriophages (phages) occurrence part causation MASLD, conversely, "phage therapy" for antibiotic resistance, obesity, are all described. metabolism bile acids dietary tryptophan histidine defined, together with impacts individual metabolites on MASLD pathogenesis. Both periodontitis dysbiosis may cause microorganisms involved these processes discussed. Novel treatment opportunities involving exist include fecal transplantation, probiotics, prebiotics, synbiotics, supplements, intermittent fasting, phages or holins endolysins. Although FDA yet approve phage therapy clinical use, there multiple FDA-approved trials, represent new horizon future

Language: Английский

Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity DOI Creative Commons
Gracia Luque, Pilar Ortíz, Alfonso Torres-Sánchez

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 14 - 14

Published: Jan. 17, 2025

Dietary exposure to the plasticiser bisphenol A (BPA), an obesogenic and endocrine disruptor from plastic epoxy resin industries, remains prevalent despite regulatory restriction food safety efforts. BPA can be accumulated in humans animals, potentially exerting differential health effects based on individual metabolic capacity. This pilot study examines impact of direct ex vivo gut microbiota obese normal-weight children, using 16S rRNA amplicon sequencing anaerobic culturing combined methods. Results showed that xenobiotic induced modifications microbial taxa relative abundance, community structure, diversity. Specifically, reduced abundance bacteria belonging phylum Bacteroidota, while Actinomycetota were promoted. Consistently, Bacteroides species classified as sensitive BPA, whereas class Clostridia identified resistant our culturomics analysis. Some altered bacterial patterns common for both BPA-exposed groups non-exposed group study. These findings also corroborated a larger cohort children. Future research will essential evaluate these potential biomarkers biomonitoring effect its role substance

Language: Английский

Citations

0
The Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Open Access
Diren Beyoğlu, Jeffrey R. Idle

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2882 - 2882

Published: March 22, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition wherein excessive fat accumulates in the liver, leading to inflammation and potential damage. In this narrative review, we evaluate tissue microbiota, how they arise their constituent microbes, role of intestinal hepatic microbiota MASLD. The history bacteriophages (phages) occurrence part causation MASLD, conversely, "phage therapy" for antibiotic resistance, obesity, are all described. metabolism bile acids dietary tryptophan histidine defined, together with impacts individual metabolites on MASLD pathogenesis. Both periodontitis dysbiosis may cause microorganisms involved these processes discussed. Novel treatment opportunities involving exist include fecal transplantation, probiotics, prebiotics, synbiotics, supplements, intermittent fasting, phages or holins endolysins. Although FDA yet approve phage therapy clinical use, there multiple FDA-approved trials, represent new horizon future

Language: Английский

Citations

0