Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers DOI Creative Commons

KVS Chaithanya,

Jan Rozman, Andrej Košmrlj

et al.

Journal of Elasticity, Journal Year: 2025, Volume and Issue: 157(2)

Published: Feb. 24, 2025

Abstract Tissue homeostasis, the biological process of maintaining a steady state in tissue via control cell proliferation and death, is essential for development, growth, maintenance, proper function living organisms. Disruptions to this can lead serious diseases even death. In study, we use vertex model cell-level description mechanics investigate impact environment local mechanical properties cells on homeostasis confined epithelial tissues. We find dynamic state, where balance between divisions removals sustains characterise homeostatic terms count, area, pressure, cells’ neighbour count distribution. This work, therefore, sheds light mechanisms underlying highlights importance its control.

Language: Английский

Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers DOI Creative Commons

KVS Chaithanya,

Jan Rozman, Andrej Košmrlj

et al.

Journal of Elasticity, Journal Year: 2025, Volume and Issue: 157(2)

Published: Feb. 24, 2025

Abstract Tissue homeostasis, the biological process of maintaining a steady state in tissue via control cell proliferation and death, is essential for development, growth, maintenance, proper function living organisms. Disruptions to this can lead serious diseases even death. In study, we use vertex model cell-level description mechanics investigate impact environment local mechanical properties cells on homeostasis confined epithelial tissues. We find dynamic state, where balance between divisions removals sustains characterise homeostatic terms count, area, pressure, cells’ neighbour count distribution. This work, therefore, sheds light mechanisms underlying highlights importance its control.

Language: Английский

Citations

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