Photoactivated Self‐Assembled Nanomicelles Integrating Mitophagy Inhibition to Enhance Pyroptosis for Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Multimodal therapy often demonstrates superior therapeutic effects compared to monotherapy. Phototherapy is a promising approach for cancer treatment, as it can induce tumor pyroptosis and activate antitumor immune responses. However, mitochondrial oxidative stress during frequently stimulates protective autophagy in cells, thereby seriously impeding the progress of pyroptosis. Therefore, developing that enhances through inhibiting critical improving treatment efficacy. In this study, photoactivated mitochondrial‐targeting self‐assembled nanomicelle ( 3M@C ) integrates an aggregation‐induced emission photosensitizer inhibitor chloroquine designed. generate both type I II reactive oxygen species heat under light exposure, inducing dysfunction triggering pyroptosis, achieving photodynamic synergistic photothermal therapy. Meanwhile, inhibit mitophagy, further enhance effects, vivo experiments demonstrate strategy exhibits excellent biosafety significant efficacy, effectively suppressing growth. addition, method nanomicelles mitophagy inhibition providing novel photoimmunotherapy.

Language: Английский

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Ir/CeO₂ Single‐Atom Nanoislands as an Atomic‐Nano System for Highly Efficient Self‐Cascade Glucose Oxidase and Peroxidase Mimics

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract The stability and activity of self‐cascade enzymes based on glucose oxidase (GOx) peroxidase (POD) are usually low, which has significant limitations in tumor catalytic therapy. Building nanoislands‐supported single‐atom nanozymes with strong atomic‐nano interaction is an effective strategy for enhancing the enzyme‐like activity. Herein, noble metal iridium (Ir) single‐atoms successfully deposited CeO 2 quantum dots (QDs) nanoislands to construct Ir/CeO (SANIs). QDs abundant oxygen vacancies facilitate efficient electron transfer Ir at metal‐nanoislands interface. A liposomal nano platform encapsulated SANIs (Ir/CeO @Lipo) further developed vivo @Lipo exhibits excellent GOx‐ POD‐like due its unique structures confined effect nanoislands. Compared other reported nanozymes, catalyzes generate more ROS higher efficiency, demonstrating superior GOx‐POD In vivo, experiments demonstrate that possesses tumor‐targeting capability as well nearly complete ablation through ROS‐mediated apoptotic pathways. Thus, this work provides a new paradigm designing treatment strategies.

Language: Английский

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The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 54

Published: April 5, 2025

Cancer is a leading cause of mortality and morbidity worldwide. Nanomaterials, unique optical, magnetic, electrical properties at the nanoscale (1-100 nm), have been engineered to improve drug capacity, bioavailability, specificity in cancer treatment. These advancements address toxicity lack selectivity conventional therapies, enabling precise targeting cells, tumor microenvironment, immune system. Among emerging approaches, bacterial treatment shows promise due its natural ability target diverse therapeutic mechanisms, which nanotechnology can further enhance. Bacteria-based delivery systems leverage bacteria's adaptability survival strategies within human body. Bacterial derivatives, such as ghosts (BGs), extracellular vesicles (BEVs), dietary toxins, are recognized effective biological nanomaterials capable carrying nanoparticles (NPs). attracted increasing attention for their potential targeted NP This study explores use various bacteria byproducts vehicles, highlighting treating different types cancer. By combining strengths therapy, these innovative approaches aim revolutionize with improved precision efficacy.

Language: Английский

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Metal‐Organic Frameworks Enable Spontaneous Singlet Oxygen Generation Without Light Irradiation

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Singlet oxygen ( 1 O 2 ) is a widely used reactive species (ROS), making the development of new materials capable efficiently generating it highly important. In this work, we report series isostructural metal‐organic frameworks (MOFs), named JNU‐300 (JNU = Jinan University), can spontaneously generate by directly activating triplet 3 from air without need for additional light irradiation. The selective generation verified electron paramagnetic resonance (EPR) spectroscopy and probe experiments . generated be employed aerobic oxidation sulfide antibacterial application. Mechanism studies revealed that framework structure, adsorption polarization coordination units JNU‐300, are crucial generation. To best our knowledge, MOFs first MOF material producing in absence at room temperature. This work provides insights into design construction functional via irradiation, opening possibilities their application specialized fields require dark.

Language: Английский

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Fluorogen‐Activating Human Serum Albumin for Mitochondrial Nanoscale Imaging

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Abstract Fluorescence nanoscopy of living cells employs contrast agents to reveal intrinsic correlations between mitochondrial dynamics and functions at the molecular level. However, regular fluorophores usually present poor photostability, low brightness, non‐specific inhibitory effects, high phototoxicity, rapid photobleaching, which have hindered use these tools capture intricate dynamic features mitochondria. Herein, we engineered a fluorogen‐activating protein (FAP), AmpHecy@HSA , non‐covalent self‐assembly HSA amphiphilic hemicyanine (AmpHecy) fluorophore, with exceptional cell permeability, long‐lasting brightness/fluorogenicity, minimal phototoxicity. Crystallography femtosecond transient absorption spectroscopy techniques were combined elucidate structural mechanistic intricacies fluorescence activation. These findings revealed that fluorophore photoactivation happens through conformation‐induced intramolecular charge transfer, whose kinetics is mainly determined by hydrophobic interaction nearby amino acids. This aligns classical simulations excited‐state conformation quantum mechanics. It was further demonstrated can be used for super‐resolved images mitochondria within without apparent work expands fluorescent toolkit based on FAP engineering studying live‐cell morphology function, advancing fields chemistry biomedicine.

Language: Английский

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Hypoxia-sensitive macrocycle inclusion complexes for targeted protein degradation

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113921 - 113921

Published: May 1, 2025

Language: Английский

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Advances on Albumin‐Based Carriers for Anticancer Drug Delivery

Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Albumin is the most abundant protein in plasma, featuring a unique chemical structure and conformation that underpins its functions. Its excellent biocompatibility, nontoxicity non‐immunogenicity make it an ideal carrier for encapsulating therapeutic agents, particularly controlled release applications cancer treatment. Although existing reviews focus on albumin‐based particulate delivery systems, there lack of comprehensive analysis from perspective using albumin's structural characteristics binding sites drug delivery. This review categorizes drug‐loading modes based surface‐active groups internal sites, emphasizing strategies targeting mechanisms. It also details preparation modification methods albumin nanoparticles, along with clinical performance evaluations. Finally, addresses current challenges proposes potential solutions. aims to provide valuable insights developing advanced anticancer drugs enhanced efficacy.

Language: Английский

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