Chiral nanoassembly remodels tumor microenvironment through non-oxygen-dependent depletion lactate for effective photodynamic immunotherapy

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123203 - 123203

Published: Feb. 21, 2025

Language: Английский

Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Cancer immunotherapy, which leverages the body's immune system to combat cancer, offers promise of lower toxicity and higher therapeutic efficacy compared conventional treatments. However, current immunotherapeutic approaches face significant challenges including variable patient response, immune‐related adverse events, high costs, underscoring urgent need for innovative strategies. Metal‐based nanomaterials have emerged as a promising avenue in cancer immunotherapy due their unique physicochemical properties immune‐regulating capabilities. Despite potential, concerns about toxicity, incomplete understanding modulation mechanisms, early‐stage design strategies hinder clinical translation. This review summarizes recent advancements metal‐based elucidates mechanisms by they enhance antitumor immunity responses, explores potential synergistic effects combining multiple metals. We also discuss key future perspectives application, aiming provide theoretical foundation development immunotherapies promote broader application treatment.

Language: Английский

Safe-by-design strategies towards bismuth-based nanomaterials in tumor diagnosis and therapy

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102714 - 102714

Published: March 15, 2025

Language: Английский