Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy DOI Creative Commons
Shuang Ma, Guangyu Zhao,

S.J. Sui

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Cancer immunotherapy, which leverages the immune system to target neoplastic cells, has undergone significant transformation in recent. However, immunotherapy may have negative effects on skeletal muscle function, causing wasting and functional decline cancer patients. In this study, we review mechanisms by influences muscle, focusing immune-related myositis, inflammation, metabolic alterations within tumor microenvironment (TME). The key methodologies, including biomechanical assessment techniques such as electrical impedance myography ultrasound imaging, are discussed provide valuable insights into process that maintain integrity function patients receiving immunotherapy. Moreover, dual of suppression damage described, revealing significance inflammatory cytokines, checkpoints, disturbances TME. Importantly, propose combination therapies integrating nutritional interventions or anti-inflammatory potential approaches for mitigating wasting. This study highlights need deeper investigations optimize improve its efficacy preserving health, thereby improving patient outcomes quality life.

Language: Английский

Cell compression – relevance, mechanotransduction mechanisms and tools DOI
Laura M. Faure, Valeria Venturini, Pere Roca‐Cusachs

et al.

Journal of Cell Science, Journal Year: 2025, Volume and Issue: 138(6)

Published: March 15, 2025

ABSTRACT From border cell migration during Drosophila embryogenesis to solid stresses inside tumors, cells are often compressed physiological and pathological processes, triggering major responses. Cell compression can be observed in vivo but also controlled vitro through tools such as micro-channels or planar confinement assays. Such have recently become commercially available, allowing a broad research community tackle the role of variety contexts. This has led discovery conserved compression-triggered modes, fate determinants mechanosensitive pathways, among others. In this Review, we will first address different ways which their biological Then, discuss distinct mechanosensing mechanotransducing pathways that activate response compression. Finally, describe systems been engineered compress cells.

Language: Английский

Citations

0
Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy DOI Creative Commons
Shuang Ma, Guangyu Zhao,

S.J. Sui

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Cancer immunotherapy, which leverages the immune system to target neoplastic cells, has undergone significant transformation in recent. However, immunotherapy may have negative effects on skeletal muscle function, causing wasting and functional decline cancer patients. In this study, we review mechanisms by influences muscle, focusing immune-related myositis, inflammation, metabolic alterations within tumor microenvironment (TME). The key methodologies, including biomechanical assessment techniques such as electrical impedance myography ultrasound imaging, are discussed provide valuable insights into process that maintain integrity function patients receiving immunotherapy. Moreover, dual of suppression damage described, revealing significance inflammatory cytokines, checkpoints, disturbances TME. Importantly, propose combination therapies integrating nutritional interventions or anti-inflammatory potential approaches for mitigating wasting. This study highlights need deeper investigations optimize improve its efficacy preserving health, thereby improving patient outcomes quality life.

Language: Английский

Citations

0