Engineering the Micro‐Nano Hierarchical Spray Hydrogel for Acute Lung Injury Therapy DOI

Yongxin Xu,

Rui Zhao, Peipei Xi

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract Acute lung injury (ALI) poses a significant threat to human health, yet specific treatments remain elusive. Despite extensive research efforts, drug delivery the lungs and reliable preclinical models are major challenges. To address these issues, novel micro‐nano hierarchical spray hydrogel is developed with enhanced targeting ability for treating ALI. The nanocomposite characterized ordered micro‐nanostructure, composing of astaxanthin nanoparticles (ASX‐NPs). Astaxanthin, natural active ingredient derived from algae, nano‐encapsulated produce ASX‐NPs, which significantly improves bioavailability. ASX‐NPs found efficiently target mitochondria relieve inflammatory responses in organoid‐based by downregulating inflammation‐ oxidative stress‐related pathways upregulating mitochondrial energy metabolism. In ALI mice, adheres tracheal mucosa rapidly releases upon inhalation. Released endocytosed alleviate inflammation promote recovery. findings suggest that this system offer promising alternative treatment, can expand applications organoids disease modeling discovery.

Language: Английский

In vivomRNA delivery to the lung vascular endothelium by dicationic Charge-Altering Releasable Transporters DOI Creative Commons

Mahmoud M. AbdElwakil,

Jun Ni, Summer Ramsay-Burrough

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Endothelial cells (EC) comprise the pulmonary vascular bed and play a significant role in health disease. Consequently, EC niche represents an attractive therapeutic target for treating wide range of diseases. We have identified new class dicationic Charge-Altering Releasable Transporters. These single-component transporters selectively deliver mRNA to lung upon intravenous administration without use targeting ligand. Significantly, number spatial array cationic charges within repeating units CART polymer are found control both delivery efficacy tissue tropism. High-resolution imaging revealed efficient endothelial arteries, veins capillaries. The selective tropism these CARTs, coupled with tunable synthesis this family amphiphiles, enabling platform research clinical applications.

Language: Английский

Citations

0
Resveratrol inhibits the formation of Staphylococcus aureus biofilms by reducing PIA, eDNA release, and ROS production DOI Creative Commons
Jianming He, Yang Cui, Yan Liu

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 30, 2025

Staphylococcus aureus is a zoonotic pathogen that difficult to control. Resveratrol (RES) has been shown have significant antibacterial effects. The present study aimed investigate the inhibitory effect of RES on formation biofilms and their molecular mechanism. First, minimum concentration action curve against were obtained through testing. Second, we found can inhibit biofilm by reducing release polysaccharide intercellular adhesion (PIA) extracellular DNA (eDNA) from aureus. treatment significantly reduced production reactive oxygen species (ROS) nicotinamide adenine dinucleotide phosphate (NADPH) in aureus, indicating ROS NADPH are closely related formation. This demonstrates inhibits PIA, eDNA release, production, these results provide new ideas for clinical application infection.

Language: Английский

Citations

0
Inflammation-Responsive nanoparticles for acute lung injury treatment through gas therapy and removal of neutrophil extracellular traps DOI
Jie Yan, Xuechun Wang, Yi‐Lei Zhao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163660 - 163660

Published: May 1, 2025

Language: Английский

Citations

0
Engineering the Micro‐Nano Hierarchical Spray Hydrogel for Acute Lung Injury Therapy DOI

Yongxin Xu,

Rui Zhao, Peipei Xi

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract Acute lung injury (ALI) poses a significant threat to human health, yet specific treatments remain elusive. Despite extensive research efforts, drug delivery the lungs and reliable preclinical models are major challenges. To address these issues, novel micro‐nano hierarchical spray hydrogel is developed with enhanced targeting ability for treating ALI. The nanocomposite characterized ordered micro‐nanostructure, composing of astaxanthin nanoparticles (ASX‐NPs). Astaxanthin, natural active ingredient derived from algae, nano‐encapsulated produce ASX‐NPs, which significantly improves bioavailability. ASX‐NPs found efficiently target mitochondria relieve inflammatory responses in organoid‐based by downregulating inflammation‐ oxidative stress‐related pathways upregulating mitochondrial energy metabolism. In ALI mice, adheres tracheal mucosa rapidly releases upon inhalation. Released endocytosed alleviate inflammation promote recovery. findings suggest that this system offer promising alternative treatment, can expand applications organoids disease modeling discovery.

Language: Английский

Citations

0