To recruit or to graft? Comparing the recruitment of resident non-neuronal cells by lineage reprogramming with engraftment of stem cell-derived neurons for neuronal replacement therapies DOI Creative Commons
Daniel A. Peterson

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 21, 2025

Neurons are post-mitotic cells that not replaced once lost, leading to the need for neuronal replacement therapies central nervous system (CNS) repair. The generation of induced pluripotent stem cell (iPSC) derived human neurons is relatively advanced, with capacity generate pure and validated populations different subtypes as clinical grade ready engraftment. Clinical trials using human-derived embryonic (hESC) iPSC-derived underway. As an alternative approach, ability target in vivo resident non-neuronal reprogramming factors induce has been demonstrated. engineer a defined population retain their cytoarchitectural location may permit additional, more focused therapeutic strategy specific circuits could complement bulk engraftment ex cell-derived neurons. This mini-review summarizes compares these two strategies offers perspective on steps needed advance recruitment complementary strategy.

Language: Английский

To recruit or to graft? Comparing the recruitment of resident non-neuronal cells by lineage reprogramming with engraftment of stem cell-derived neurons for neuronal replacement therapies DOI Creative Commons
Daniel A. Peterson

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 21, 2025

Neurons are post-mitotic cells that not replaced once lost, leading to the need for neuronal replacement therapies central nervous system (CNS) repair. The generation of induced pluripotent stem cell (iPSC) derived human neurons is relatively advanced, with capacity generate pure and validated populations different subtypes as clinical grade ready engraftment. Clinical trials using human-derived embryonic (hESC) iPSC-derived underway. As an alternative approach, ability target in vivo resident non-neuronal reprogramming factors induce has been demonstrated. engineer a defined population retain their cytoarchitectural location may permit additional, more focused therapeutic strategy specific circuits could complement bulk engraftment ex cell-derived neurons. This mini-review summarizes compares these two strategies offers perspective on steps needed advance recruitment complementary strategy.

Language: Английский

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