The metabolic underpinnings of sebaceous lipogenesis DOI Creative Commons
Maria Schmidt, Hans Binder, Marlon R. Schneider

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 27, 2025

Abstract Sebaceous glands synthesize and secrete sebum, a mélange of lipids other cellular products that safeguards the mammalian integument. Differentiating sebocytes delaminate from basal membrane dislodge towards gland’s middle, where they eventually undergo poorly understood death mode in which whole cell becomes secretion product (holocrine secretion). Supported by recent transcriptomics data, this review examines idea peripheral have remarkable ability to draw nutrients blood become committed unrestrainedly invest all available resources into synthetic processes for accomplishing sebum synthesis, thereby exploiting core metabolic fluxes as glycogen turnover, glutamine-directed anaplerosis, pentose phosphate pathway de novo lipogenesis. Finally, we propose metabolic-driven are an important mechanistic component holocrine secretion. A deeper understanding these adaptations could indicate novel strategies modulating key pathogenic factor acne skin diseases.

Language: Английский

The metabolic underpinnings of sebaceous lipogenesis DOI Creative Commons
Maria Schmidt, Hans Binder, Marlon R. Schneider

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 27, 2025

Abstract Sebaceous glands synthesize and secrete sebum, a mélange of lipids other cellular products that safeguards the mammalian integument. Differentiating sebocytes delaminate from basal membrane dislodge towards gland’s middle, where they eventually undergo poorly understood death mode in which whole cell becomes secretion product (holocrine secretion). Supported by recent transcriptomics data, this review examines idea peripheral have remarkable ability to draw nutrients blood become committed unrestrainedly invest all available resources into synthetic processes for accomplishing sebum synthesis, thereby exploiting core metabolic fluxes as glycogen turnover, glutamine-directed anaplerosis, pentose phosphate pathway de novo lipogenesis. Finally, we propose metabolic-driven are an important mechanistic component holocrine secretion. A deeper understanding these adaptations could indicate novel strategies modulating key pathogenic factor acne skin diseases.

Language: Английский

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