Cell Cycle, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20
Published: April 22, 2025
Microtubules are polymers of α/β tubulin dimers that build the mitotic spindle, which segregates duplicated chromosomes during cell division. Microtubule function is governed by dynamic instability, whereby cycles growth and shrinkage contribute to forces necessary for chromosome movement. Regulation microtubule velocity requires cycle-dependent changes in expression, localization activity microtubule-associated proteins (MAPs) as well post-translational modifications modulate dynamics. It has become clear optimal velocities required proper segregation ploidy maintenance. Suboptimal rates can result from altered MAPs could lead aneuploidy, possibly disrupting establishment bundles at kinetochores altering mechanical sister chromatid segregation. Future work using high-resolution, low-phototoxicity microscopy novel fluorescent markers will be invaluable obtaining deeper mechanistic insights into how processes
Language: Английский