Salmonella-Derived Fluorescent Carbon Dots for Reprogramming Tumor-Associated Macrophages and Enhancing Tumor Photodynamic Therapy DOI

Pei‐Jie Zhang,

Dong Zhou, Ziwei Yang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 24, 2025

Carbon dots (CDs) are used as photosensitizers for the photodynamic therapy of tumors while retaining specific functional groups and biochemical properties carbon precursors. However, short-wavelength excitation limits their application in tumors. Upconversion nanoparticles (UCNPs) effectively solve problem low penetration due to by converting low-energy near-infrared light into high-energy ultraviolet or visible light. In this paper, were prepared a hydrothermal method using Salmonella alendronic acid raw materials, phosphate on surface coordinated with upconversion form UCNP@CD nanoprobes. Under irradiation an 808 nm laser, emitted from can further catalyze enhance generation reactive oxygen species killing tumor cells. Meanwhile, reprogrammed M2 macrophages M1 improve immunosuppressive microenvironment. The nanoprobes tumor-associated macrophage reprogramming tumors, which provides effective strategy multimodal synergistic treatment.

Language: Английский

Salmonella-Derived Fluorescent Carbon Dots for Reprogramming Tumor-Associated Macrophages and Enhancing Tumor Photodynamic Therapy DOI

Pei‐Jie Zhang,

Dong Zhou, Ziwei Yang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 24, 2025

Carbon dots (CDs) are used as photosensitizers for the photodynamic therapy of tumors while retaining specific functional groups and biochemical properties carbon precursors. However, short-wavelength excitation limits their application in tumors. Upconversion nanoparticles (UCNPs) effectively solve problem low penetration due to by converting low-energy near-infrared light into high-energy ultraviolet or visible light. In this paper, were prepared a hydrothermal method using Salmonella alendronic acid raw materials, phosphate on surface coordinated with upconversion form UCNP@CD nanoprobes. Under irradiation an 808 nm laser, emitted from can further catalyze enhance generation reactive oxygen species killing tumor cells. Meanwhile, reprogrammed M2 macrophages M1 improve immunosuppressive microenvironment. The nanoprobes tumor-associated macrophage reprogramming tumors, which provides effective strategy multimodal synergistic treatment.

Language: Английский

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