Harnessing the Power of Natural Products for Targeted Protein Degradation DOI

Bo Zhu,

Zheng Wu,

Yiwen Shou

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Natural products have garnered significant attention due to their complex chemical structures and remarkable pharmacological activities. With inherent recognition capabilities for protein surfaces, natural serve as ideal candidates designing proteolysis‐targeting chimeras (PROTACs). The utilization of in PROTAC development offers distinct advantages, including rich diversity, multitarget activities, sustainable sourcing. This comprehensive review explores the vast potential harnessing research. Moreover, discusses application degradant technology, which involves utilizing product‐based compounds selectively degrade disease‐causing proteins, well implementation computer‐aided drug design (CADD) technology identifying suitable targets degradation within realm products. By power leveraging computational tools, PROTACs derived from revolutionize discovery provide innovative therapeutic interventions various diseases.

Language: Английский

Harnessing the Power of Natural Products for Targeted Protein Degradation DOI

Bo Zhu,

Zheng Wu,

Yiwen Shou

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Natural products have garnered significant attention due to their complex chemical structures and remarkable pharmacological activities. With inherent recognition capabilities for protein surfaces, natural serve as ideal candidates designing proteolysis‐targeting chimeras (PROTACs). The utilization of in PROTAC development offers distinct advantages, including rich diversity, multitarget activities, sustainable sourcing. This comprehensive review explores the vast potential harnessing research. Moreover, discusses application degradant technology, which involves utilizing product‐based compounds selectively degrade disease‐causing proteins, well implementation computer‐aided drug design (CADD) technology identifying suitable targets degradation within realm products. By power leveraging computational tools, PROTACs derived from revolutionize discovery provide innovative therapeutic interventions various diseases.

Language: Английский

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