Likarska sprava, Journal Year: 2025, Volume and Issue: 2
Published: May 26, 2025
Hyperuricemia (HUr) is not only a consequence of impaired purine metabolism but also an independent risk factor for the development and progression chronic kidney disease (CKD). This article provides systematic review current pathophysiological mechanisms renal tissue damage in HUr, particularly activation oxidative stress, inflammatory cascades, endothelial dysfunction, fibrosis development. Special attention given to uromodulin (Umod) as biomarker tubular system potential mediator nephropathological processes. The reviews literature on therapeutic antioxidants, particular glutathione ubiquinone, context pathogenetically targeted therapy CKD associated with hyperuricemia. based sources published between 2021 2025 does include primary results from authors’ own clinical observations. Conclusions: In CKD, hyperuricemia requires multifactorial diagnostic approach, taking into account role stress prospects antioxidant therapy.
Language: Английский