Trends in biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Life, Journal Year: 2025, Volume and Issue: 15(5), P. 745 - 745
Published: May 6, 2025
The integration of artificial intelligence and personalized medicine is transforming HIV management by enhancing diagnostics, treatment optimization, disease monitoring. Advances in machine learning, deep neural networks, multi-omics data analysis enable precise prognostication, tailored antiretroviral therapy, early detection drug resistance. AI-driven models analyze vast genomic, proteomic, clinical datasets to refine strategies, predict progression, pre-empt therapy failures. Additionally, AI-powered diagnostic tools, including learning imaging natural language processing, improve screening accuracy, particularly resource-limited settings. Despite these innovations, challenges such as privacy, algorithmic bias, the need for validation remain. Successful AI into care requires robust regulatory frameworks, interdisciplinary collaboration, equitable technology access. This review explores both potential limitations management, emphasizing ethical implementation expanded research maximize its impact. approaches hold great promise a more personalized, efficient, effective future care.
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(10), P. 731 - 731
Published: May 13, 2025
Integrated photonic biosensors are revolutionizing lab-on-a-chip technologies by providing highly sensitive, miniaturized, and label-free detection solutions for a wide range of biological chemical targets. This review explores the foundational principles behind their operation, including use resonant structures such as microring whispering gallery mode resonators, well interferometric crystal-based designs. Special focus is given to design strategies that optimize light–matter interaction, enhance sensitivity, enable multiplexed detection. We detail state-of-the-art fabrication approaches compatible with complementary metal-oxide-semiconductor processes, silicon, silicon nitride, hybrid material platforms, which facilitate scalable production seamless integration microfluidic systems. Recent advancements highlighted, implementation optofluidic crystal cavities, cascaded arrays subwavelength gratings, on-chip detector capable parallel biosensing. These innovations have achieved exceptional performance, limits reaching parts-per-billion level real-time operation across various applications clinical diagnostics, environmental surveillance, food quality assessment. Although challenges persist in handling complex samples achieving consistent large-scale fabrication, emergence novel materials, advanced nanofabrication methods, artificial intelligence-driven data analysis accelerating development next-generation biosensing platforms. poised deliver powerful, accessible, cost-effective diagnostic tools practical deployment diverse settings.
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Microfluidic paper-based analytical devices (μPADs) are powerful tools for diagnostic and environmental monitoring. Being affordable portable, μPADs enable rapid detection of small molecules, heavy metals, biomolecules, thereby decentralizing diagnostics expanding biosensor accessibility. However, the reliance on two-dimensional fluid flow restricts utility conventional μPADs, presenting challenges applications that require simultaneous multibiomarker analysis from a single sample. Vertical (VF-μPADs) overcome this challenge by allowing axial movement through paper stacks, offering several advantages, including (1) enhanced multiplexing capabilities, (2) reduced hook effect improved accuracy, (3) shorter assay times. This review provides an overview VF-μPADs technologies, exploring structural functional performance trade-offs between lateral systems. The sensing performance, fabrication methods, in vitro monitoring discussed. Furthermore, critical challenges─such as complexity, data analysis, scalability─are addressed, along with proposed strategies mitigating these barriers to facilitate broader adoption. By examining strengths challenges, presents potential advance point-of-care testing, particularly resource-limited settings.
Language: Английский
Citations
0
Trends in biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0