The Plant Journal,
Journal Year:
2024,
Volume and Issue:
121(1)
Published: Dec. 1, 2024
SUMMARY
DNA,
is
assaulted
by
endogenous
and
exogenous
agents
that
lead
to
the
formation
of
damage.
In
order
maintain
genome
integrity
DNA
repair
pathways
must
be
efficiently
activated
prevent
mutations
deleterious
chromosomal
rearrangements.
Conversely,
rearrangement
also
necessary
allow
genetic
diversity
evolution.
The
antagonist
interaction
between
maintenance
rearrangements
determines
shape
organization.
Therefore,
it
great
interest
understand
how
whole
linear
structure
behaves
upon
For
this,
we
used
long
reads
sequencing
technology
identify
characterize
genomic
structural
variations
(SV)
wild‐type
Arabidopsis
thaliana
somatic
cells
exposed
either
UV‐B,
UV‐C
or
protons
irradiations.
We
found
regions
located
in
heterochromatin
are
more
prone
form
SVs
than
those
euchromatin,
highlighting
stability
differs
along
chromosome.
This
holds
true
plants
deficient
for
expression
master
regulators
damage
response
(DDR),
ATM
(Ataxia‐telangiectasia‐mutated)
ATR
(Ataxia‐telangiectasia‐mutated
Rad3‐related),
suggesting
independent
alternative
surveillance
processes
exist
genic
regions.
Finally,
analysis
radiations‐induced
deleted
allowed
determining
exposure
induced
microhomology‐mediated
end
joining
mechanism
(MMEJ)
both
repress
this
pathway.
Genes,
Journal Year:
2025,
Volume and Issue:
16(1), P. 95 - 95
Published: Jan. 17, 2025
DNA
damage
response
(DDR)
contributes
to
seed
quality
by
guarding
genome
integrity
in
the
delicate
phases
of
pre-
and
post-germination.
As
a
key
determinant
stress
tolerance
resilience,
DDR
has
notable
implications
on
wider
scale
agroecosystems
challenged
harsh
climatic
events.
The
present
review
focuses
existing
documented
links
that
interconnect
efficiency
with
an
array
molecular
hallmarks
biochemical,
molecular,
physiological
valence
within
metabolic
networks.
expression
genes
encoding
sensors,
transducers,
mediators,
effectors
is
interpreted
as
source
conserved
hallmarks,
along
markers
oxidative
reflecting
seed’s
ability
germinate.
Similarly,
accumulation
patterns
proteins
metabolites
contribute
stability
are
predictive
traits.
While
list
candidates
presented
from
multiple
models
crop
species,
their
interaction
chromatin
dynamics,
cell
cycle
progression,
hormonal
regulation
provides
further
levels
analysis
investigate
holistically.
identification
novel
seeds
constitutes
framework
prompt
validation
different
experimental
systems,
refine
current
pre-germinative
metabolism,
promote
targeted
approaches
for
evaluation.
Physiologia Plantarum,
Journal Year:
2025,
Volume and Issue:
177(2)
Published: March 1, 2025
DNA
damage
caused
by
internal
and
external
stresses
negatively
affects
plant
growth
development.
In
this,
repair
enzymes
play
an
important
role
in
recognizing
repairing
the
damage.
The
first
key
base
excision
(BER)
pathway
are
glycosylases.
this
paper,
we
present
updated
knowledge
on
classification,
phylogeny
conserved
structural
domains
of
glycosylases
pathway.
It
describes
roles
played
stress
responses,
focuses
molecular
mechanisms
tolerance
from
perspective
system.
New
opportunities
for
development
plant-derived
genes
enzyme
resources
discussed.
Journal of Integrative Plant Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Genetic
screening
in
Arabidopsis
reveals
that
clathrin,
a
well-known
regulator
of
endocytosis,
is
required
for
homologous
recombination,
precise
mechanism
repairing
DNA
double-
strand
breaks.
Notably,
CLATHRIN
LIGHT
CHAIN
2
localizes
the
nucleus,
suggesting
clathrin
has
non-canonical
functions
nucleus.
PeerJ,
Journal Year:
2024,
Volume and Issue:
12, P. e17864 - e17864
Published: Aug. 28, 2024
Meiosis
is
a
critical
process
in
sexual
reproduction,
and
errors
during
this
cell
division
can
significantly
impact
fertility.
Successful
meiosis
relies
on
the
coordinated
action
of
numerous
genes
involved
DNA
replication,
strand
breaks,
subsequent
rejoining.
topoisomerase
enzymes
play
vital
role
by
regulating
topology,
alleviating
tension
replication
transcription.
To
elucidate
specific
function
1α
(
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 25, 2024
ABSTRACT
DNA,
is
assaulted
by
endogenous
and
exogenous
agents
that
lead
to
the
formation
of
damage.
In
order
maintain
genome
integrity
DNA
repair
pathways
must
be
efficiently
activated
prevent
mutations
deleterious
chromosomal
rearrangements.
Conversely,
flexibility
also
necessary
allow
genetic
diversity
evolution.
The
antagonist
interaction
between
maintenance
determines
shape
organization.
Therefore,
it
great
interest
understand
how
whole
linear
structure
behaves
upon
For
this,
we
used
long
reads
sequencing
technology
identify
characterize
genomic
structural
variations
(SV)
wild-type
Arabidopsis
thaliana
somatic
cells
exposed
either
UV-B,
UV-C
or
protons
irradiations.
We
found
regions
located
in
heterochromatin
a
more
prone
form
SVs
than
those
euchromatin,
highlighting
stability
differs
along
chromosome.
This
holds
true
plants
deficient
for
expression
master
regulators
Damage
Response
(DDR),
ATM
ATR,
suggesting
independent
alternative
surveillance
processes
exist
genic
regions.
Finally,
analysis
radiations-induced
deleted
allowed
determining
exposure
induced
Microhomology-mediated
end
joining
mechanism
(MMEJ)
both
ATR
repress
this
pathway.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8940 - 8940
Published: Aug. 16, 2024
Environmental
variations
initiate
chromatin
modifications,
leading
to
the
exchange
of
histone
subunits
or
repositioning
nucleosomes.
The
phosphorylated
variant
H2A.X
(γH2A.X)
is
recognized
for
formation
foci
that
serve
as
established
markers
DNA
double-strand
breaks
(DSBs).
Nevertheless,
precise
roles
in
cellular
response
genotoxic
stress
and
impact
plant
hormone
abscisic
acid
(ABA)
remain
incompletely
understood.
In
this
investigation,
we
implemented
CRISPR/Cas9
technology
produce
loss-of-function
mutants
