Published: Jan. 1, 2025
Language: Английский
Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: 20(9), P. 569 - 585
Published: July 18, 2024
Language: Английский
Citations
35
Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 672 - 672
Published: March 17, 2024
(1) Background: Cognitive decline (CD), considered a precursory state of dementia, is frequently encountered in patients with diabetes mellitus type 2 (DM-2) and might even have higher prevalence those associated atrial fibrillation (AF). In this study, we aimed to research if the association DM-2 AF favors precocious onset CD. (2) Methods: This study was conducted on 160 patients, featuring 50 DM-2, 54 AF, 56 subjects without all evaluated clinically five neuropsychiatric scales. (3) Results: The Mini-Mental-State-Examination (MMSE), Montreal Assessment (MoCA), Activities Daily Living Score (ADL), Instrumental (IADL), Geriatric Depression Scale (GDS-15) were significantly altered comparison these diseases. logistic regression model indicated that, an increase one year age 7.3% augmentation risk CD (MMSE < 27). (4) Conclusions: more frequent especially when versus AF. Our findings suggest that older dyslipidemia represent factors for DM-2.
Language: Английский
Citations
9
Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: Feb. 5, 2025
Abstract Neuroinflammation is closely linked to aging, which damages the structure and function of brain. It caused by intricate interactions immune cells in aged brain, such as dysregulated glial dysfunctional astrocytes. Aging-associated chronic low inflammation, referred neuroinflammaging, shows an upregulated proinflammatory response. Autophagy senescence play crucial roles moderators aging neuroinflammatory responses. The neuroimmune system, dystrophic cells, release factors alter blood-brain barrier, causing a landscape. Chronic inflammation combined with deteriorating neurons exacerbate neurological disorders decline cognitive function. This review highlights neuroinflammaging mechanism associated interplay central nervous system cellular senescence, autophagy regulation brain's under conditions. Moreover, microglia peripheral process brain have also been discussed. Determining treatment targets comprehending mechanisms that influence necessary decrease neuroinflammation.
Language: Английский
Citations
1
Science Advances, Journal Year: 2025, Volume and Issue: 11(10)
Published: March 5, 2025
Cross-sectional age-skill profiles suggest that cognitive skills start declining by age 30 if not earlier. If accurate, such age-driven skill losses pose a major threat to the human capital of societies with rapidly aging populations. We estimate actual from individual changes in literacy and numeracy at different ages. use unique German longitudinal component Programme International Assessment Adult Competencies (PIAAC-L) retested large representative sample adults after 3.5 years. Our empirical approach separates cohort effects corrects for measurement error reversion mean. Two main results emerge. First, average increase strongly into forties before decreasing slightly more numeracy. Second, decline older ages only those below-average usage. White-collar higher-educated workers above-average usage show increasing even beyond their forties. Women have larger age, particularly
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3442 - 3442
Published: June 12, 2024
Dementia remains an underdiagnosed syndrome, and there is a need to improve the early detection of cognitive decline. This narrative review examines role neuropsychological assessment in characterization changes associated with dementia syndrome at different states. The first section describes indicators decline major barriers their identification. Further, optimal screening conditions most widely accepted tests are described. second analyzes main differences performance between Alzheimer’s disease other subtypes dementia. Finally, current challenges aging/dementia future approaches discussed. Essentially, we find that research beginning uncover precede dementia, while continuing refine differential diagnosis neurodegenerative disorders cause However, neuropsychology faces several barriers, including cultural diversity populations, limited implementation public health systems, adaptation technological advances. Nowadays, plays fundamental characterizing stages but more efforts needed develop harmonized procedures facilitate its use clinical contexts protocols.
Language: Английский
Citations
6
Journal of Sports Sciences, Journal Year: 2024, Volume and Issue: 42(2), P. 109 - 115
Published: Jan. 17, 2024
This study examined the separate and combined associations of obesity handgrip strength with cognitive function in older adults. In total 4,839 adults were included this cross-sectional study, their body mass index (BMI) measured. Cognitive was evaluated using Telephone Interview for Status. Three individual categories created BMI (normal weight: 18.5≤ < 24.0 kg/m2 overweight: 24.0≤ 28.0 obesity: ≥ (low, normal, high tertiles), then these pooled together. Logistic regression analyses used to examine function. Results indicated that overweight had a lower rate than normal weight There an inverse association between Participants likelihood compared those strength. The findings suggested or associated odds decline. Moreover, concurrence additive effect on
Language: Английский
Citations
4
Current Opinion in Supportive and Palliative Care, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 9, 2024
Purpose of review The importance the gut microbiome for human health and well-being is generally accepted, elucidating signaling pathways between host offers novel mechanistic insight into (patho)physiology multifaceted aspects healthy aging brain functions. Recent findings tightly linked with nervous system, microbiota are increasingly emerging as important regulators emotional cognitive performance. They send receive signals bidirectional communication via immunological, neuroanatomical, humoral pathways. composition spectrum metabolites neurotransmitters that they release changes increasing age, nutrition, hypoxia, other pathological conditions. Changes in (dysbiosis) associated critical illnesses such cancer, cardiovascular, chronic kidney disease but also neurological, mental, pain disorders, well chemotherapies antibiotics affecting development function. Summary Dysbiosis a concomitant imbalance mediators both causes consequences diseases brain. Understanding microbiota’s role pathogenesis these disorders will have major clinical implications offer new opportunities therapeutic interventions.
Language: Английский
Citations
4
Trends in Cognitive Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 563 - 563
Published: Jan. 16, 2025
Background: The interdependence between type 2 diabetes mellitus (DM-2), atrial fibrillation (AF), and cognitive decline (CD)/dementia is a debated topic. In this study, we highlighted the influence of DM-2 FA individually in association on severity CD/dementia. Methods: This study comprises 248 patients with very high cardiovascular risk (VHCVR) according to Systematic Coronary Risk Evaluation (SCORE2), whom 184 had and/or AF, 64 were age-matched controls (without DM-2/AF), admitted Municipal Hospital Timisoara. Results: Mini-Mental-State-Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities Daily Living Score (ADL), Instrumental (IADL) significantly decreased, Geriatric Depression Scale (GDS-15) increased AF comparison (p < 0.05), subjects having more severe CD compared those only one these two pathologies. logistic regression model showed that (MMSE 27) or dementia 24) depending SCORE2 values, ADL, GDS-15. patients, an increase 1% was associated elevation 2.40% odds 4.30% dementia. depression (GDS score) by 36.3%, if ADL improved, decreased 44.0%. Conclusions: Our findings suggest direct CD, DM-2, SCORE2, parameters, depression. it important identify subclinical prevent evolution
Language: Английский
Citations
0
Research on Aging, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
This study examines whether age-related cognitive decline varies by race/ethnicity and how edentulism moderates these effects. Data from the Health Retirement Study (2006-2020), including 23,669 respondents aged 51 above across 189,352 person-wave observations were analyzed. Of all respondents, 13.4% edentulous at baseline, with 65.4% identified as non-Hispanic White, 20.5% Black, 14.18% Hispanic. Results linear mixed-effect models indicated that compared to Whites, Hispanic Black participants exhibited lower baseline cognition scores but slower age. For participants, this rate of was attenuated 0.03 units per year (95% CI: -0.06, -0.01, p = .049). The findings highlighted need for targeted interventions policies improve oral health, particularly populations. Addressing health disparities could help mitigate in group reduce racial/ethnic groups.
Language: Английский
Citations
0