Differentiating Tangerine Peels from Other Citrus reticulata through GC-MS, UPLC-Q-Exactive Orbitrap-MS, and HPLC-PDA DOI Creative Commons
Zhen Song,

Jiepei Xu,

Jingyuan Tian

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 10(1), P. 1688 - 1704

Published: Dec. 27, 2024

The nonvolatile and volatile compounds in the peels of 13 Citrus reticulata cultivars (4 mandarins, 5 tangerines, 4 hybrids) sinensis (sweet oranges) were analyzed. Initially, 66 detected using gas chromatography–mass spectrometry (GC-MS). Tangerines distinguished from other citrus (mandarins, sweet oranges, by having higher oil extraction rates relative contents o-Cymene, α-Terpinene, d-α-Pinene, Terpinolene, γ-Terpinene, l-β-Pinene, 3-Thujene. Additionally, 115 tentatively identified ultraperformance liquid chromatography-Q-Exactive Orbitrap tandem mass (UPLC-Q-Exactive Orbitrap-MS). C. contained fewer than did reticulata. Pterostilbene was all tangerines but not mandarins hybrids, suggesting its potential as a marker compound for differentiating Lastly, high-performance chromatography-photodiode array (HPLC-PDA) used to quantify 9 major components. Heat map principal component analysis showed that differed hybrids). It may be caused content synephrine, nobiletin, tangeretin, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone tangerines. study obtain information application different types (tangerines, or peels, thereby promoting their recycling.

Language: Английский

Regulation of and challenges in targeting NAD+ metabolism DOI
Marie E. Migaud, Mathias Ziegler, Joseph A. Baur

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(10), P. 822 - 840

Published: July 18, 2024

Language: Английский

Citations

13
NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control DOI Creative Commons
Shin‐ichiro Imai

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 27, 2025

Abstract Over the past five years, systemic NAD + (nicotinamide adenine dinucleotide) decline has been accepted to be a key driving force of aging in field research. The original version World concept was proposed 2009, providing an integrated view -centric, regulatory network for mammalian and longevity control. reformulated concept, 2.0, then 2016, emphasizing importance inter-tissue communications between hypothalamus peripheral tissues including adipose tissue skeletal muscle. There significant progress our understanding nicotinamide mononucleotide (NMN), intermediate, phosphoribosyltransferase (NAMPT), particularly extracellular NAMPT (eNAMPT). With these exciting developments, further 3.0, is now proposed, featuring multi-layered feedback loops mediated by NMN eNAMPT

Language: Английский

Citations

1
Use of Nicotinamide Mononucleotide as Non-Natural Cofactor DOI Open Access
Tahseena Naaz, Beom Soo Kim

Catalysts, Journal Year: 2025, Volume and Issue: 15(1), P. 37 - 37

Published: Jan. 3, 2025

Nicotinamide mononucleotide (NMN) has emerged as a promising non-natural cofactor with significant potential to transform biocatalysis, synthetic biology, and therapeutic applications. By modulating NAD⁺ metabolism, NMN offers unique advantages in enzymatic reactions, metabolic engineering, regenerative medicine. This review provides comprehensive analysis of NMN’s biochemical properties, mechanisms action, diverse Emphasis is placed on its role addressing challenges multi-enzyme cascades, biofuel production, the synthesis high-value chemicals. The paper also highlights critical research gaps, including need for scalable methods, improved integration into systems, toxicity studies use. Emerging technologies such AI-driven enzyme design CRISPR-based genome engineering are discussed transformative tools optimizing NMN-dependent pathways. Furthermore, synergistic biology innovations, cell-free systems dynamic regulatory networks, explored, paving way precise modular biotechnological solutions. Looking forward, versatility positions it pivotal tool advancing sustainable bioprocessing precision Addressing current limitations through interdisciplinary approaches will enable redefine boundaries innovation. serves roadmap leveraging across scientific industrial domains.

Language: Английский

Citations

0
Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications DOI Creative Commons
Candace Benjamin,

Rebecca Crews

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 341 - 341

Published: June 18, 2024

Recent years have seen a surge in research focused on NAD+ decline and potential interventions, despite significant progress, new discoveries continue to highlight the complexity of biology. Nicotinamide mononucleotide (NMN), well-established precursor, has garnered considerable interest due its capacity elevate levels induce promising health benefits preclinical models. Clinical trials investigating NMN supplementation yielded variable outcomes while shedding light intricacies metabolism revealing critical roles played by gut microbiota specific cellular uptake pathways. Individual variability factors such as lifestyle, conditions, genetics, microbiome composition likely contributes observed discrepancies clinical trial results. Preliminary evidence suggests that NMN’s effects may be context-dependent, varying based person’s physiological state. Understanding these nuances is for definitively assessing impact manipulating through supplementation. Here, we review metabolism, focusing current knowledge, pinpointing key areas where further needed, outlining future directions advance our understanding significance.

Language: Английский

Citations

3
Nicotinamide Mononucleotide: Deciphering Metabolic Complexities for Improved Health Outcomes DOI Open Access
Candace Benjamin,

Rebecca Crews

Published: March 28, 2024

Nicotinamide mononucleotide (NMN), a key NAD+ precursor, exhibits distinct metabolic characteristics and potential health benefits. Recent investigations underscore the pivotal role of gut bacteria specialized uptake mechanisms in NMN metabolism. While human trials demonstrate NMN's safety promising outcomes, challenges persist. Variability results is likely influenced by lifestyle, conditions, individual genetic microbiota differences. Understanding how these factors affect metabolism crucial for personalized approaches maximizing potential. Advances delivery systems show promise enhancing bioavailability, but further understanding optimal levels reliable measures effects necessary. This comprehensive approach to optimizing impact on longevity.

Language: Английский

Citations

1
<b>Neurotoxic effects of type II-diabetes mellitus and the possible preventive effects of olive leaves supplement in male rats</b> DOI Creative Commons

Sarah Hussein Abdulwahid Al-Hafidh,

Ammar Ahmed Abdulwahid

Open Veterinary Journal, Journal Year: 2024, Volume and Issue: 14(10), P. 2651 - 2651

Published: Jan. 1, 2024

Diabetes mellitus (DM) is a common metabolic disorder with well-known serious secondary complications. It also associated central nervous system damage. This damage characterized by impairments in brain functions, neurochemical and structural abnormalities.

Language: Английский

Citations

0
Differentiating Tangerine Peels from Other Citrus reticulata through GC-MS, UPLC-Q-Exactive Orbitrap-MS, and HPLC-PDA DOI Creative Commons
Zhen Song,

Jiepei Xu,

Jingyuan Tian

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 10(1), P. 1688 - 1704

Published: Dec. 27, 2024

The nonvolatile and volatile compounds in the peels of 13 Citrus reticulata cultivars (4 mandarins, 5 tangerines, 4 hybrids) sinensis (sweet oranges) were analyzed. Initially, 66 detected using gas chromatography–mass spectrometry (GC-MS). Tangerines distinguished from other citrus (mandarins, sweet oranges, by having higher oil extraction rates relative contents o-Cymene, α-Terpinene, d-α-Pinene, Terpinolene, γ-Terpinene, l-β-Pinene, 3-Thujene. Additionally, 115 tentatively identified ultraperformance liquid chromatography-Q-Exactive Orbitrap tandem mass (UPLC-Q-Exactive Orbitrap-MS). C. contained fewer than did reticulata. Pterostilbene was all tangerines but not mandarins hybrids, suggesting its potential as a marker compound for differentiating Lastly, high-performance chromatography-photodiode array (HPLC-PDA) used to quantify 9 major components. Heat map principal component analysis showed that differed hybrids). It may be caused content synephrine, nobiletin, tangeretin, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone tangerines. study obtain information application different types (tangerines, or peels, thereby promoting their recycling.

Language: Английский

Citations

0