Exploration of the Muribaculaceae Family in the Gut Microbiota: Diversity, Metabolism, and Function

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2660 - 2660

Published: Aug. 12, 2024

The gut microbiota are mainly composed of

Language: Английский

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Research progress on the mechanism of functional activity of edible fungi polysaccharides—focusing intestinal mucus as a key and entry point

Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(1), P. 9420042 - 9420042

Published: Sept. 18, 2024

Language: Английский

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Sesamin Alleviates Allergen-Induced Diarrhea by Restoring Gut Microbiota Composition and Intestinal Barrier Function

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Food allergens are the key triggers of allergic diarrhea, causing damage to immune-rich ileum. This weakens mucosal barrier and tight junctions, increases intestinal permeability, exacerbates allergen exposure, thereby worsening condition. Sesamin, a natural lignan isolated from sesame seed, has shown potential in regulating immune responses, but its effects on health remain unclear. In this study, we constructed an ovalbumin (OVA)-induced diarrhea mouse model, which demonstrated increased mast cell degranulation, reduced junction integrity, impaired function. Pro-inflammatory cytokines were significantly ileum, along with unbalanced cluster differentiation 4 (CD4

Language: Английский

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Journey of dietary fiber along the gastrointestinal tract: role of physical interactions, mucus, and biochemical transformations

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 29

Published: Aug. 14, 2024

Dietary fiber-rich foods have been associated with numerous health benefits, including a reduced risk of cardiovascular and metabolic diseases. Harnessing the potential to deliver positive outcomes rests on our understanding underlying mechanisms that drive these associations. This review addresses data concepts concerning plant-based food functionality by dissecting cascade physical chemical digestive processes interactions underpin physiological benefits. Functional transformations dietary fiber along gastrointestinal tract from stages oral processing gastric emptying intestinal digestion colonic fermentation influence its capacity modulate digestion, transit, commensal microbiome. analysis highlights significance, limitations, challenges in decoding complex web establish coherent framework connecting specific components' molecular macroscale across multiple length scales within tract. One critical area requires closer examination is interaction between fiber, mucus barrier, microbiome when considering structure design personalized nutritional strategies for beneficial physiologic effects. Understanding response fibers, particularly an individual's physiology, will offer opportunity exploit functional characteristics elicit specific, symptom-targeting effects or use types as adjunctive therapies.

Language: Английский

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Preventive effect of quinoa polysaccharides on lipopolysaccharide-induced inflammation in mice through gut microbiota regulation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141899 - 141899

Published: March 1, 2025

Language: Английский

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Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(9)

Published: Feb. 18, 2025

Runchangningshen paste (RCNSP) is a made of four medicinal and edible homologous Chinese medicine mixed with honey. It known for its ability to nourish yin blood as well loosen the bowel relieve constipation. The pathophysiology functional constipation (FC) associated reduction in mucin-2 (MUC2) secretion microbial dysbiosis. To investigate underlying mechanism RCNSP against FC through MUC2 gut mucosal microbiota. Ultra-performance liquid chromatography tandem mass spectrometry characterized composition elucidate material basis action. model was induced via loperamide gavage (16 mg/kg) twice daily 7 days. Applying defecation function gastrointestinal motility assess severity. Hematoxylin eosin Alcian blue-periodic acid-schiff staining analyzed colonic morphology. Transmission electron microscope used observe ultrastructure goblet cells (GCs). Immunofluorescence colocalization, quantitative PCR, western blot assessed impact on gene protein expression within NLRP6/autophagy pathway. 16S rDNA employed sequence contained 12 components potential laxative effects. enhanced function, accelerated motility, maintained integrity. treatment significantly increased GC abundance production while preserving ultrastructure. At molecular level, colocalized key regulatory proteins modulated mRNA expressions Through sequencing analysis, altered microbiota composition. Specifically, it beneficial bacterial strains reducing harmful ones. Simultaneously, reduced butyrate-producing bacteria like Proteobacteria, Enterobacteriaceae, Blautia, Eubacterium decreased hydrogen sulfide-producing species, such Prevotellaceae. also bile acid-inhibiting g_Eubacter_coprostanoligenes_group Erysipelotrichaceae increasing acid-producing Colidextribacter. Our findings suggested that ameliorated dual mechanism: stimulated by activating NLRP6 inflammasome-mediated autophagy

Language: Английский

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Red snapper protein prevents chronic unpredictable mild stress-induced ileal barrier damage by reversing microbiota-derived butyric acid overload

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106233 - 106233

Published: Feb. 1, 2025

Language: Английский

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Online PGC–LC–MS analysis of colonic mucin O-glycans in ovalbumin-induced food allergy in Balb/c mice by treatment with sea cucumber chondroitin sulfate polysaccharide

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141808 - 141808

Published: March 5, 2025

Language: Английский

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Living on the edge: Mucus-associated microbes in the colon

Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

The colonic mucus layer acts as a physicochemical barrier to pathogen invasion and habitat for mucus-associated microbes. This mucosal microbiome plays crucial role in moderating production, maintaining integrity, shaping the host immune response. However, unchecked mucin foraging may render vulnerable disease. To better understand these dynamics layer, it is essential advance fundamental knowledge on how commensals bind utilize well their interactions with both microbial neighbors. We present an overview of approaches surveying bacteria assessing mucin-utilizing capacity, alongside discussion limitations existing methods. Additionally, we highlight diet secretory immunoglobulin A interact bacterial community colon. Insights into this subset can guide therapeutic strategies optimally support modulate integrity.

Language: Английский

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Sialylation in the gut: From mucosal protection to disease pathogenesis

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122471 - 122471

Published: July 9, 2024

Language: Английский

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