International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 12719 - 12742
Published: Nov. 1, 2024
Hydrogels
can
be
rationally
designed
as
multifunctional
platforms
with
structures
and
functions
for
various
biomedical
applications.
Because
of
their
excellent
biochemical
mechanical
properties,
hydrogels
have
shown
great
potential
promoting
angiogenesis,
an
increasing
amount
research
has
been
devoted
to
designing
developing
new
hydrogels.
However,
a
systematic
detailed
review
that
promote
angiogenesis
is
lacking.
This
paper
comprehensively
summarizes
the
design
strategies
different
kinds
functional
anti-oxidant,
substance-delivery,
stimulus-responsive,
self-healing,
conductive,
wound-monitoring
properties.
The
applications
in
wound
healing,
bone
regeneration,
treatment
myocardial
ischemia
are
discussed.
Finally,
future
development
directions
proposed
along
related
diseases.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(2), P. 107 - 107
Published: Feb. 13, 2025
MXene
is
a
new
family
of
two-dimensional
nanomaterials
with
outstanding
electrical
conductivity,
tunable
structure,
biocompatibility,
and
large
surface
area.
Thanks
to
these
unique
physicochemical
properties,
has
been
used
for
constructing
electrochemical
sensors
(MECSens)
excellent
performance.
In
particular,
the
abundant
termination
can
contribute
greatly
enhancing
analytical
sensitivity
selectivity
MECSens.
Recently,
MECSens
have
widely
applied
in
many
fields
including
clinical
diagnosis,
infectious
disease
surveillance,
food
security.
However,
not
all
materials
are
suitable
building
sensors.
this
article,
we
present
an
overview
different
that
developed
so
far.
We
begin
short
summary
preparation
characterization
Subsequently,
performance,
detection
strategies,
application
scenarios
classified
briefly
discussed.
The
article
ends
conclusion
future
perspectives.
hope
will
be
helpful
designing
activity
analysis.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(31)
Published: Aug. 22, 2024
The
prevalence
of
drug-resistant
bacterial
infections
has
emerged
as
a
grave
threat
to
clinical
treatment
and
global
human
health,
presenting
one
the
foremost
challenges
in
medical
care.
Thus,
there
is
an
urgent
imperative
develop
safe
efficacious
novel
antimicrobial
strategies.
Nitric
oxide
(NO)
recognized
endogenous
signaling
molecule,
which
plays
pivotal
role
numerous
pathological
processes.
Currently,
NO
garnered
significant
interest
antibacterial
agent
due
its
capability
eradicate
bacteria,
disrupt
biofilms,
facilitate
wound
healing,
all
while
circumventing
emergence
drug
resistance.
However,
inherently
unstable
characteristic
therapeutic
gas
renders
controlled
administration
gases
exceedingly
challenging.
Hence,
this
review,
current
challenge
infection
discussed;
then
it
briefly
elucidated
mechanism
comprehensively
delineate
recent
advancements
stimulus-responsive
delivery
platforms,
along
with
their
merits,
obstacles,
prospective
avenues
for
application.
This
review
offers
guidance
future
NO-medicated
anti-infection
therapy
hoped.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
In
recent
years,
the
use
of
MXenes,
a
class
two-dimensional
materials
composed
transition
metal
carbides,
nitrides,
or
carbonitrides,
has
shown
significant
promise
in
field
skin
wound
healing.
This
review
explores
multifunctional
properties
focusing
on
their
electrical
conductivity,
photothermal
effects,
and
biocompatibility
this
field.
MXenes
have
been
utilized
to
develop
advanced
healing
devices
such
as
hydrogels,
patches,
smart
bandages
for
examination.
These
offer
enhanced
antibacterial
activity,
promote
tissue
regeneration,
provide
real-time
monitoring
parameters.
The
highlights
synthesis
methods,
chemical
features,
biological
effects
emphasizing
role
innovative
repair
strategies.
Additionally,
it
discusses
potential
MXene-based
sensors
humidity,
pH,
temperature
monitoring,
which
are
crucial
preventing
infections
complications
integration
into
wearable
represents
advancement
management,
promising
improved
clinical
outcomes
quality
life
patients.
Materials,
Journal Year:
2025,
Volume and Issue:
18(3), P. 685 - 685
Published: Feb. 4, 2025
This
study
employs
a
Monte
Carlo-based
3D
compressive
percolation
model
to
systematically
analyze
the
electrical
behavior
of
flexible
electronic
composites
under
deformation.
By
simulating
spatial
distribution
and
connectivity
conductive
particles,
this
identifies
six
distinct
cases,
each
describing
unique
evolution
strain.
The
reveals
that
excessive
initial
leads
saturation
effects,
reducing
sensitivity,
while
high
Poisson’s
ratio
(≥0.3)
causes
loss
due
shear
plane
expansion.
Notably,
asymmetric
particle
shapes,
such
as
cylinders
rectangles,
exhibit
superior
behavior,
forming
infinite
clusters
at
lower
strain
thresholds
(~0.4)
compared
spherical
particles
(~0.5).
Carlo
simulations
with
3000
validate
these
findings,
showing
consistent
trends
in
across
different
deformation
states.
classifying
quantifying
scenarios,
research
provides
structured
framework
for
optimizing
sensor
designs,
ensuring
an
optimal
balance
between
conductivity
sensitivity.
These
findings
contribute
advancing
electronics,
particularly
wearable
health
monitoring,
robotics,
smart
textiles.
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 283 - 283
Published: April 11, 2025
In
recent
years,
conductive
polymer
hydrogels
based
on
polypyrrole
(PPy)
combined
with
electrical
stimulation
(ES)
have
emerged
as
a
promising
approach
for
chronic
wound
repair.
However,
in
practical
applications,
PPy
often
exhibits
limitations
such
poor
water
dispersion,
weak
inherent
conductivity
and
lack
of
biological
functionality.
To
address
these
challenges,
this
study
proposes
an
innovative
design
hydrogel
that
employs
natural
biopolymer,
lignin
sulfonate
(Lgs),
both
dispersant
dopant
PPy,
while
incorporating
silver
nanoparticles
(Ag
NPs)
to
confer
the
antibacterial
properties.
The
results
showed
dispersion
was
significantly
improved,
high
2.82
±
0.04
mS/cm
through
double
conduction
mechanism
Ag
NPs.
exhibited
activity
against
Escherichia
coli
(E.
coli)
Staphylococcus
aureus
(S.
aureus),
rate
could
exceed
90%.
vitro
tests
demonstrated
good
biocompatibility,
adhesion
ability
(7.97
0.56
kPa)
hemostatic
ability.
Furthermore,
vivo
animal
experiments
ES
achieved
93.71
2.46%
closure
within
14
days,
which
can
accelerate
healing,
promote
collagen
deposition
epithelial
tissue
regeneration.
These
findings
demonstrate
developed
serve
effective
platform
ES-assisted
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Abstract
Conductive
hydrogel‐based
flexible
electronic
skin,
or
“E‐skin,”
patches
have
garnered
significant
attention
in
biomedical
engineering
due
to
their
capability
sense
and
detect
real‐time
human
motion,
health
metrics,
environmental
changes.
Nonetheless,
challenges
such
as
precision
fabrication,
enhanced
flexibility,
superior
self‐healing,
hydrophilicity,
insufficient
bioadhesive
properties
impede
clinical
application
limit
advancement
wearable
bioelectronics.
In
this
context,
the
development
of
a
highly
flexible,
shape‐reconfigurable,
stretchable,
printable
conductive
“E‐skin”
patch
for
humidity,
temperature
sensing.
This
utilizes
polyvinyl
alcohol/gelatin/carbon
nanotubes/cellulose
nanocrystals
(PVA/Gelatin/CNTs/CNCs
PVG/NC)
based
hydrogel
inspired
by
slime
molds.
Modifying
PVG
with
CNTs
CNCs
enhances
mechanical
viscoelastic
properties,
thereby
facilitating
high‐resolution
direct
ink
writing
(DIW)
3D
printing.
The
resulting
slime‐like
demonstrates
an
electrical
conductivity
≈5
±
0.25
S
m
−1
,
exceptional
stretchability
(≈1000%).
nanocomposite
also
displays
outstanding
multiple
sensing
capabilities
temperature,
humidity
under
ambient
conditions.
Furthermore,
PVG/NC
showcases
remarkable
near‐infrared
(NIR)
responsive
attributes,
which
can
be
leveraged
eradicating
pathogenic
bacteria
chronic
wounds
exhibit
excellent
cytocompatibility.
research
holds
immense
promise
future
bioelectronics,
particularly
non‐invasive
medical
diagnostics.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 15, 2025
Abstract
Wound
healing
is
a
dynamic
and
overlapping
bio‐process
with
varied
cellular
molecular
characteristics
involved.
Traditional
wound
dressings
have
made
significant
achievements
in
accelerating
healing;
however,
they
lack
the
ability
to
monitor
changes
of
wounds,
which
limits
effectiveness
management.
Currently,
development
flexible
electronics‐based
intelligent
that
can
real‐time
manner
make
positive
impact
on
clinical
practice.
MXenes,
also
known
as
type
2D
inorganic
compound,
are
generally
considered
ideal
precursors
for
fabricating
electronics.
MXenes‐based
electronics
not
only
biomarkers
wounds
(e.g.,
temperature,
pH,
lactic
acid)
but
promote
by
combining
other
bio‐activities.
This
review
begins
brief
introduction
challenges
associated
early
diagnosis
wounds.
It
then
provides
comprehensive
summary
discussion
fabrication
applications
monitoring
treatment.
Finally,
it
explores
current
future
directions
this
cutting‐edge
field.