Recent Advances in MXene-Based Electrochemical Sensors

Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 107 - 107

Published: Feb. 13, 2025

MXene is a new family of two-dimensional nanomaterials with outstanding electrical conductivity, tunable structure, biocompatibility, and large surface area. Thanks to these unique physicochemical properties, has been used for constructing electrochemical sensors (MECSens) excellent performance. In particular, the abundant termination can contribute greatly enhancing analytical sensitivity selectivity MECSens. Recently, MECSens have widely applied in many fields including clinical diagnosis, infectious disease surveillance, food security. However, not all materials are suitable building sensors. this article, we present an overview different that developed so far. We begin short summary preparation characterization Subsequently, performance, detection strategies, application scenarios classified briefly discussed. The article ends conclusion future perspectives. hope will be helpful designing activity analysis.

Language: Английский

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Stimuli‐Responsive NO Delivery Platforms for Bacterial Infection Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)

Published: Aug. 22, 2024

The prevalence of drug-resistant bacterial infections has emerged as a grave threat to clinical treatment and global human health, presenting one the foremost challenges in medical care. Thus, there is an urgent imperative develop safe efficacious novel antimicrobial strategies. Nitric oxide (NO) recognized endogenous signaling molecule, which plays pivotal role numerous pathological processes. Currently, NO garnered significant interest antibacterial agent due its capability eradicate bacteria, disrupt biofilms, facilitate wound healing, all while circumventing emergence drug resistance. However, inherently unstable characteristic therapeutic gas renders controlled administration gases exceedingly challenging. Hence, this review, current challenge infection discussed; then it briefly elucidated mechanism comprehensively delineate recent advancements stimulus-responsive delivery platforms, along with their merits, obstacles, prospective avenues for application. This review offers guidance future NO-medicated anti-infection therapy hoped.

Language: Английский

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Advanced approaches in skin wound healing – a review on the multifunctional properties of MXenes in therapy and sensing

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In recent years, the use of MXenes, a class two-dimensional materials composed transition metal carbides, nitrides, or carbonitrides, has shown significant promise in field skin wound healing. This review explores multifunctional properties focusing on their electrical conductivity, photothermal effects, and biocompatibility this field. MXenes have been utilized to develop advanced healing devices such as hydrogels, patches, smart bandages for examination. These offer enhanced antibacterial activity, promote tissue regeneration, provide real-time monitoring parameters. The highlights synthesis methods, chemical features, biological effects emphasizing role innovative repair strategies. Additionally, it discusses potential MXene-based sensors humidity, pH, temperature monitoring, which are crucial preventing infections complications integration into wearable represents advancement management, promising improved clinical outcomes quality life patients.

Language: Английский

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Disposable Wireless FET Paper Sensor based on MWCNT/MXene/MoS Composite for Non-Invasive Glucose Detection in Saliva

Journal of Alloys and Compounds, Journal Year: 2025, Volume and Issue: unknown, P. 178715 - 178715

Published: Jan. 1, 2025

Language: Английский

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Technological Aspects of MXenes: Current Challenges and Future Perspectives

Clean Energy Production Technologies, Journal Year: 2025, Volume and Issue: unknown, P. 233 - 247

Published: Jan. 1, 2025

Language: Английский

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Lignin-Mediated Dual Conductive Hydrogels with High Conductivity, Antibacterial Activity and Biocompatibility for Chronic Wound Repair

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 283 - 283

Published: April 11, 2025

In recent years, conductive polymer hydrogels based on polypyrrole (PPy) combined with electrical stimulation (ES) have emerged as a promising approach for chronic wound repair. However, in practical applications, PPy often exhibits limitations such poor water dispersion, weak inherent conductivity and lack of biological functionality. To address these challenges, this study proposes an innovative design hydrogel that employs natural biopolymer, lignin sulfonate (Lgs), both dispersant dopant PPy, while incorporating silver nanoparticles (Ag NPs) to confer the antibacterial properties. The results showed dispersion was significantly improved, high 2.82 ± 0.04 mS/cm through double conduction mechanism Ag NPs. exhibited activity against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus), rate could exceed 90%. vitro tests demonstrated good biocompatibility, adhesion ability (7.97 0.56 kPa) hemostatic ability. Furthermore, vivo animal experiments ES achieved 93.71 2.46% closure within 14 days, which can accelerate healing, promote collagen deposition epithelial tissue regeneration. These findings demonstrate developed serve effective platform ES-assisted

Language: Английский

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Characterizing Six Percolation Cases in Flexible Electronic Composites: A Monte Carlo-Based 3D Compressive Percolation Model for Wearable Pressure Sensors

Materials, Journal Year: 2025, Volume and Issue: 18(3), P. 685 - 685

Published: Feb. 4, 2025

This study employs a Monte Carlo-based 3D compressive percolation model to systematically analyze the electrical behavior of flexible electronic composites under deformation. By simulating spatial distribution and connectivity conductive particles, this identifies six distinct cases, each describing unique evolution strain. The reveals that excessive initial leads saturation effects, reducing sensitivity, while high Poisson’s ratio (≥0.3) causes loss due shear plane expansion. Notably, asymmetric particle shapes, such as cylinders rectangles, exhibit superior behavior, forming infinite clusters at lower strain thresholds (~0.4) compared spherical particles (~0.5). Carlo simulations with 3000 validate these findings, showing consistent trends in across different deformation states. classifying quantifying scenarios, research provides structured framework for optimizing sensor designs, ensuring an optimal balance between conductivity sensitivity. These findings contribute advancing electronics, particularly wearable health monitoring, robotics, smart textiles.

Language: Английский

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Bacterial Programmed Cell Death Induced by Nanotherapeutic Strategies

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(9), P. 4209 - 4229

Published: Aug. 19, 2024

Programmed cell death (PCD) is crucial for renewal, embryogenesis, the immune response, tissue growth regulation, and other essential biological processes. Recent evidence underscores potential of harnessing PCD to combat bacterial infections, particularly in eradicating antibiotic-resistant superbugs. Extensive efforts have been devoted developing PCD-mediated anti-infective agents by drawing insights from materials science, chemistry, immunology, microbiology. In this review, challenges addressing infections PCD-based approaches revolutionize treatment are first summarized discussed. Then, a comprehensive examination nanoantibacterial therapy, encompassing various pathways, such as apoptosis, ferroptosis, cuproptosis, immunogenic death, NETosis, autophagy, pyroptosis, provided. Finally, barriers prospects PCD-driven antimicrobial strategies explored.

Language: Английский

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Recent Advances in Potential Biomedical Applications of MXene‐Based Hydrogels

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Nov. 29, 2024

ABSTRACT MXene‐based hydrogels represent a significant advancement in biomedical material science, leveraging the unique properties of 2D MXenes and versatile functionality hydrogels. This review discusses recent developments integration into hydrogel matrices, focusing on their applications such as wound healing, drug delivery, antimicrobial activity, tissue engineering, biosensing. MXenes, due to remarkable electrical conductivity, mechanical robustness, tunable surface chemistry, enhance properties, responsiveness environmental stimuli. Specifically, have shown great promise accelerating healing through photothermal effects, delivering drugs controlled manner, serving antibacterial agents. Their also enables targeted cancer therapies, including chemodynamic facilitated by high conductivity properties. Despite promising progress, challenges ensuring biocompatibility optimizing synthesis for large‐scale production remain. aims provide comprehensive overview current state applications, highlighting ongoing advancements potential future directions these multifunctional materials.

Language: Английский

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Concentration‐Dependent Effects of MXene Nanocomposite‐Loaded Carboxymethyl Cellulose on Wound Healing

Biotechnology Journal, Journal Year: 2024, Volume and Issue: 19(10)

Published: Oct. 1, 2024

ABSTRACT Nanoparticles (NPs) have emerged as a promising solution for many biomedical applications. Although not all particles antimicrobial or regenerative properties, certain NPs show promise in enhancing wound healing by promoting tissue regeneration, reducing inflammation, and preventing infection. Integrating various can further enhance these effects. Herein, the zinc oxide (ZnO)‐MXene‐Ag nanocomposite was prepared, conjugation of its three components confirmed through scanning electron microscopy (SEM) energy dispersive X‐ray (EDX) mapping analysis. In vitro analysis using agar well diffusion technique demonstrated that ZnO‐MXene‐Ag exhibited high efficacy, significantly inhibiting Escherichia coli , Salmonella Candida albicans showing enhanced potency when combined with tetracycline, resulting 2.6‐fold increase against Staphylococcus 2.4‐fold Pseudomonas . The efficacy nanocomposite‐loaded carboxymethyl cellulose (CMC) gel on investigated varying concentrations (0, 1, 5, 10 mg/mL). Wound monitored over 21 days, results indicating wounds treated 1 mg/mL superior compared to control group (0 mg/mL), significant improvements noted from Day 3 onward. Conversely, higher (10 mg/mL) resulted reduced efficiency, particularly notable 15. conclusion, CMC is agent These findings highlight importance optimizing NP concentration maximize therapeutic benefits while minimizing potential cytotoxicity.

Language: Английский

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