Association between choroid plexus volume and cognition in Parkinson disease DOI
Seong Ho Jeong,

Hyun‐Jae Jeong,

Mun Kyung Sunwoo

et al.

European Journal of Neurology, Journal Year: 2023, Volume and Issue: 30(10), P. 3114 - 3123

Published: July 27, 2023

Abstract Background and purpose The choroid plexus (CP) clears harmful metabolites from the central nervous system as part of glymphatic system. We investigated association CP volume (CPV) with baseline longitudinal cognitive decline in patients Parkinson disease (PD). Methods retrospectively reviewed medical records 240 newly diagnosed PD who had undergone detailed neuropsychological tests high‐resolution T1‐weighted structural magnetic resonance imaging during initial assessment. CPV each patient was automatically segmented, intracranial ratio used subsequent analyses. relationship between composite scores domain assessed using multivariate linear regression A Cox proportional hazards model to compare risk dementia conversion CPV. Results negatively correlated frontal/executive function (β = −0.375, p 0.002) after adjusting for age, sex, years education, parkinsonian symptom duration. revealed that a larger associated higher (hazard [HR] 1.509, 0.038), which no longer significant domain. mediation analysis demonstrated effect on completely mediated by (direct effect: HR 1.203, 0.396; indirect 1.400, 0.015). Conclusions Baseline is function, subsequently influences PD.

Language: Английский

New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases DOI Creative Commons
Yujie Sun,

Qiankun Lv,

Junyi Liu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106791 - 106791

Published: Jan. 6, 2025

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial (ISF), facilitates movement metabolic substances within brain, serving functions akin to those peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on removal pathological in ND. article elucidates recent discoveries regarding system updates relevant concepts model. It discusses potential roles ND, including Alzheimer's disease (AD), Parkinson's (PD), multiple atrophy (MSA), proposes as therapeutic target for these conditions.

Language: Английский

Citations

2
Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy DOI
Jiajie Xu, Ya Su, Jiayu Fu

et al.

European Journal of Neurology, Journal Year: 2022, Volume and Issue: 29(10), P. 2895 - 2904

Published: June 17, 2022

Cerebral amyloid angiopathy (CAA) is characterized by β-amyloid deposition in cortical and leptomeningeal arterioles, which might result from glymphatic dysfunction. The aim was to explore function CAA using the non-invasive diffusion tensor image analysis along perivascular space method.Sixty-three patients with were prospectively recruited together seventy age- sex-matched normal controls. Mini-Mental State Examination Montreal Cognitive Assessment applied screen global cognitive status. Magnetic resonance imaging scans conducted calculate index for diffusivity (ALPS index), linear regression models used assess its relationships cerebral small vessel disease (CSVD) markers, status blood biomarkers. Cox proportional hazard role of baseline ALPS recurrence.Patients exhibited a lower than controls globally (p < 0.001). In addition, related more enlarged basal ganglia = 0.026), lacunes 0.001), higher white matter hyperintensity Fazekas score 0.049), elevated total magnetic burden CSVD 0.034) 0.001) as well CAA. During median follow-up 4.1 years, associated recurrence 0.022). also negatively correlated serum soluble intercellular adhesion molecule-1, neurofilament light chitinase-3-like protein 1 CAA.Patients showed impaired function. significantly severity, impairment

Language: Английский

Citations

39
Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function DOI Creative Commons
Xiaodan Liu, Giuseppe Barisano, Xingfeng Shao

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2023

The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from MarkVCID consortium were included in this study. Two pipelines by using DSI studio FSL software developed for processing ALPS index calculation. obtained average of bilateral used testing cross-vendor, inter-rater test-retest R software. demonstrated favorable inter-scanner reproducibility (ICC=0.77 0.95, P< 0.001), (ICC=0.96 1, 0.001) repeatability (ICC=0.89 offering a potential biomarker vivo evaluation GS

Language: Английский

Citations

32
Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson’s disease DOI
Seong Ho Jeong, Chae Jung Park, Hyun-Jae Jeong

et al.

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2023, Volume and Issue: 94(12), P. 1047 - 1055

Published: June 30, 2023

Background The choroid plexus (CP) is involved in the clearance of harmful metabolites from brain, as a part glymphatic system. This study aimed to investigate association between CP volume (CPV), nigrostriatal dopaminergic degeneration and motor outcomes Parkinson’s disease (PD). Methods We retrospectively searched drug-naïve patients with early-stage PD who underwent dopamine transporter (DAT) scanning MRI. Automatic segmentation was performed, CPV calculated. relationship CPV, DAT availability Unified Rating Scale Part III (UPDRS-III) scores assessed using multivariate linear regression. performed longitudinal analyses assess according CPV. Results negatively associated each striatal subregion (anterior caudate, β=−0.134, p=0.012; posterior β=−0.162, p=0.002; anterior putamen, β=−0.133, p=0.024; β=−0.125, p=0.039; ventral p=0.035), except for striatum. positively UPDRS-III score even after adjusting putamen (β=0.121; p=0.035). A larger future development freezing gait Cox regression model (HR 1.539, p=0.027) more rapid increase medication mixed (CPV×time, p=0.037), but not risk developing levodopa-induced dyskinesia or wearing off. Conclusion These findings suggest that has potential serve biomarker baseline disabilities PD.

Language: Английский

Citations

30
The Association of the Glymphatic Function with Parkinson's Disease Symptoms: Neuroimaging Evidence from Longitudinal and Cross‐Sectional Studies DOI

Peikun He,

Lin Shi, Yanyi Li

et al.

Annals of Neurology, Journal Year: 2023, Volume and Issue: 94(4), P. 672 - 683

Published: June 28, 2023

Emerging pathological evidence suggests that there is an association between glymphatic dysfunction and the progression of Parkinson's disease (PD). However, clinical this remains lacking.In study, index for diffusion tensor image analysis along perivascular space (ALPS index) was calculated to evaluate function.Overall, 289 patients with PD were enrolled in cross-sectional study. The ALPS found be negatively correlated age, severity, dyskinesia. In longitudinal information on a total 95 5-year follow-up examinations collected from Progression Marker Initiative, 33 which classified into low group, all others mid-high group based first tertile baseline index. results regression indicated significant main effect autonomic dysfunction, as well activities daily living. addition, had faster deterioration MDS-UPDRS part III II, Symbol Digit Modalities Test Hopkins Verbal Learning Test. Path showed acted mediator tTau/ Aβ1-42 cognitive change score at year 4 5.The index, neuroimaging marker function, motor symptoms, predictive symptoms function. Additionally, function may mediate role toxic protein decline. ANN NEUROL 2023;94:672-683.

Language: Английский

Citations

25
Orexin pathway in Parkinson’s disease: a review DOI
Mohammed Alrouji, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(7), P. 6107 - 6120

Published: May 8, 2023

Language: Английский

Citations

24
Correlation of glymphatic system abnormalities with Parkinson’s disease progression: a clinical study based on non-invasive fMRI DOI

Jing‐Cai Meng,

Mingqiang Shen,

Yanli Lu

et al.

Journal of Neurology, Journal Year: 2023, Volume and Issue: 271(1), P. 457 - 471

Published: Sept. 27, 2023

Language: Английский

Citations

24
Diffusion Tensor Imaging‐Along the Perivascular‐Space Index Is Associated with Disease Progression in Parkinson's Disease DOI

Kimberly H. Wood,

Rodolphe Nenert,

Aya M. Miften

et al.

Movement Disorders, Journal Year: 2024, Volume and Issue: 39(9), P. 1504 - 1513

Published: July 11, 2024

Abstract Background The glymphatic clearance pathway is a waste system that allows for removal of soluble proteins such as amyloid β (Aβ) from the brain. Higher Aβ levels are associated with cognitive dysfunction in Parkinson's disease (PD). Diffusion tensor imaging‐along perivascular space (DTI‐ALPS) an imaging measure proposed to indirectly function. Objectives Evaluate differences DTI‐ALPS‐index between PD and healthy controls (HC) characterize relationships this clearance, cognition, severity PD. Methods (n = 32) HC 23) participants underwent brain assess DTI‐ALPS. were classified PD‐normal cognition (PD‐NC; n 20) or PD‐mild impairment (PD‐MCI; 12) based on Level II comprehensive assessment. A subgroup 21) returned annual assessments up 4 years after baseline. Longitudinal outcomes included changes performance assessment Movement Disorders Society Unified Disease Rating Scale (MDS‐UPDRS). Results had lower compared HC. PD‐MCI significantly PD‐NC. Lower at baseline was longitudinal decline worse severity. Conclusions Glymphatic measured DTI‐ALPS, has potential serve marker progression. Interventions targeting function should be explored slow © 2024 International Parkinson Disorder Society.

Language: Английский

Citations

15
Relationship of Perivascular Space Markers With Incident Dementia in Cerebral Small Vessel Disease DOI
Hui Hong, Daniel J. Tozer, Hugh S. Markus

et al.

Stroke, Journal Year: 2024, Volume and Issue: 55(4), P. 1032 - 1040

Published: March 11, 2024

BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between PVS, measured DTI-ALPS and PVS volume, cognition incident dementia. METHODS: In patients with lacunar stroke confluent white matter hyperintensities, without dementia at baseline, recruited prospectively a single center, magnetic resonance imaging was performed annually for 3 years, cognitive assessments, including global, memory, executive function, processing speed, 5 years. volume disease markers (white hyperintensity lacunes, microbleeds) baseline changes markers. whether change over years predicted Analyses controlled conventional metrics 2 (median mean diffusivity [MD] peak width of skeletonized MD) adjusted age, sex, vascular risk factors. RESULTS: A total 120 patients, age 70.0 65.0% male, included. declined while no found. Neither nor associated marker progression. Baseline global (β=0.142, P =0.032), (β=0.287, =0.027), long-term memory (β=0.228, =0.027). Higher lower (hazard ratio, 0.328 [0.183–0.588]; <0.001), this remained significant after median MD as covariate 0.290 [0.139–0.602]; <0.001). Change conversion 0.630 [0.428–0.964]; =0.048), when entered covariates, association not significant. There or to CONCLUSIONS: predicts future strokes hyperintensities. However, weakening controlling suggests part signal may represent metrics. is predictor risk.

Language: Английский

Citations

13
The glymphatic system and multiple sclerosis: An evolving connection DOI Creative Commons
Alaa Alghanimy, Lorraine M. Work, William M. Holmes

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 83, P. 105456 - 105456

Published: Jan. 21, 2024

Language: Английский

Citations

9