Author Response: Age-related differences in the functional topography of the locus coeruleus: implications for cognitive and affective functions DOI Open Access
Dániel Veréb, Mite Mijalkov, Anna Canal‐Garcia

et al.

Published: Aug. 17, 2023

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown the LC heterogeneous connections cellular features, no yet assessed functional topography vivo, how this heterogeneity changes over aging whether it associated with cognition mood. Here we employ gradient-based approach to characterize organization using 3T resting-state fMRI population-based cohort aged from 18 88 years old (Cambridge Centre for Ageing Neuroscience cohort, n=618). We show exhibits rostro-caudal gradient along longitudinal axis, which was replicated independent dataset (Human Connectome Project 7T dataset, n=184). main direction consistent across age groups, spatial features varied increasing age, emotional memory emotion regulation. More specifically, loss rostral-like connectivity, more clustered greater asymmetry between right left gradients higher worse behavioral performance. Furthermore, participants higher-than-normal Hospital Anxiety Depression Scale ratings exhibited alterations as well, manifested asymmetry. These results provide vivo account aging, imply are relevant markers LC-related measures psychopathology.

Language: Английский

Age-related differences in the functional topography of the locus coeruleus: implications for cognitive and affective functions DOI Creative Commons
Dániel Veréb, Mite Mijalkov, Anna Canal‐Garcia

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 1, 2023

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown the LC heterogeneous connections cellular features, no yet assessed functional topography vivo, how this heterogeneity changes over aging whether it associated with cognition mood. Here we employ gradient-based approach to characterize organization using 3T resting-state fMRI population-based cohort aged from 18 88 years old (Cambridge Centre for Ageing Neuroscience cohort, n=618). We show exhibits rostro-caudal gradient along longitudinal axis, which was replicated independent dataset (Human Connectome Project 7T dataset, n=184). main direction consistent across age groups, spatial features varied increasing age, emotional memory emotion regulation. More specifically, loss rostral-like connectivity, more clustered greater asymmetry between right left gradients higher worse behavioral performance. Furthermore, participants higher-than-normal Hospital Anxiety Depression Scale ratings exhibited alterations as well, manifested asymmetry. These results provide vivo account aging, imply are relevant markers LC-related measures psychopathology.

Language: Английский

Citations

3
Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies DOI Creative Commons
Lubomira Novakova, Martin Gajdoš,

Marek Bartoň

et al.

Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 121, P. 106031 - 106031

Published: Feb. 10, 2024

Language: Английский

Citations

0
Bibliometric analysis of global research trends in magnetic resonance imaging studies of substantia nigra in Parkinson’s disease (2001–2024) DOI Creative Commons
Mei Jiang, Xu Deng, Zixiong Qiu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Sept. 3, 2024

Background Parkinson’s disease (PD) is a globally prevalent neurodegenerative disorder, primarily characterized by muscle rigidity, resting tremor, and bradykinesia. The incidence of PD rapidly escalating worldwide. Numerous studies have been conducted on the application magnetic resonance imaging (MRI) in investigating substantia nigra (SN) patients. However, to date, no bibliometric analysis has performed this specific research area. Therefore, study aimed provide comprehensive current status MRI SN Materials methods records related patients from 2001 2024 were searched using Web Science Core Collection (WOSCC) database then CiteSpace VOSviewer used conduct analysis. Results Our found that number published articles showed an overall upward trend over past decade, which Lehericy, Stephane, Du, Guangwei, Huang, Xuemei are top three authors with most articles. Additionally, United States, China Germany main contributors PD. And Shanghai Jiao Tong University, University Florida Seoul National leading institutions field. Finally, keyword hotspots trends field mainly concentrated quantitative susceptibility mapping, neuroimaging, neuromelanin-sensitive MRI. Conclusion These identified influential authors, institutions, countries SN-MRI PD, reference significance for interest provides new idea prevention.

Language: Английский

Citations

0
Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies DOI Creative Commons

Žaneta Železníková,

Ľubomíra Nováková,

Ľubomír Vojtíšek

et al.

Movement Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Although neuromelanin-sensitive magnetic resonance imaging (NM-MRI) has been used to evaluate early neurodegeneration in Parkinson's disease, studies concentrating on the locus coeruleus (LC) pre-dementia stages of dementia with Lewy bodies (DLB) are lacking.

Language: Английский

Citations

0
Striatal-cortical dysconnectivity underlies somatosensory deficits in Parkinson's disease: Insights from rhythmic auditory-motor training DOI Creative Commons
Cheng‐Wei Huang, Hsin-Yun Tsai, Yi‐Hsuan Lin

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106778 - 106778

Published: Dec. 1, 2024

Language: Английский

Citations

0
Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions DOI Creative Commons
Dániel Veréb, Mite Mijalkov, Anna Canal‐Garcia

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Aug. 31, 2023

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown the LC heterogeneous connections cellular features, no yet assessed functional topography vivo, how this heterogeneity changes over aging, whether it associated with cognition mood. Here, we employ gradient-based approach to characterize organization aging using 3T resting-state fMRI population-based cohort aged from 18 88 years age (Cambridge Centre for Ageing Neuroscience cohort, n=618). We show exhibits rostro-caudal gradient along longitudinal axis, which was replicated independent dataset (Human Connectome Project [HCP] 7T dataset, n=184). main direction consistent across groups, spatial features varied increasing age, emotional memory, emotion regulation. More specifically, loss rostral-like connectivity, more clustered topography, greater asymmetry between right left gradients higher worse behavioral performance. Furthermore, participants higher-than-normal Hospital Anxiety Depression Scale (HADS) ratings exhibited alterations as well, manifested asymmetry. These results provide vivo account imply are relevant markers LC-related measures psychopathology.

Language: Английский

Citations

1
Author Response: Age-related differences in the functional topography of the locus coeruleus: implications for cognitive and affective functions DOI Open Access
Dániel Veréb, Mite Mijalkov, Anna Canal‐Garcia

et al.

Published: Aug. 17, 2023

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown the LC heterogeneous connections cellular features, no yet assessed functional topography vivo, how this heterogeneity changes over aging whether it associated with cognition mood. Here we employ gradient-based approach to characterize organization using 3T resting-state fMRI population-based cohort aged from 18 88 years old (Cambridge Centre for Ageing Neuroscience cohort, n=618). We show exhibits rostro-caudal gradient along longitudinal axis, which was replicated independent dataset (Human Connectome Project 7T dataset, n=184). main direction consistent across age groups, spatial features varied increasing age, emotional memory emotion regulation. More specifically, loss rostral-like connectivity, more clustered greater asymmetry between right left gradients higher worse behavioral performance. Furthermore, participants higher-than-normal Hospital Anxiety Depression Scale ratings exhibited alterations as well, manifested asymmetry. These results provide vivo account aging, imply are relevant markers LC-related measures psychopathology.

Language: Английский

Citations

0