Cognitive Impairment-Associated Risk Factors of Parkinson’s Disease: A Hospital-Based Study in a Cohort of Upper Egypt Parkinson’s Patients DOI Creative Commons
Eman M. Khedr,

Khaled O. Aboshaera,

Ahmed A. Karim

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 459 - 459

Published: April 27, 2025

Background/Objectives: Cognitive impairment (CI) in Parkinson’s disease (PD) is a major burden and significantly affects patients’ quality of life. Previous studies found that older age at onset presence the akinetic–rigid (AR) subtype are associated with an increased likelihood CI PD. The present study aimed to assess factors related development Methods: Eighty-three PD patients were consecutively recruited. Demographic information, clinical details, Montreal cognitive assessment (MoCA), Movement Disorder Society Unified Disease Rating Scale (MDS-UPDRS), walking speed, instrumental activity daily living (IADL) assessed. Resting motor threshold (rMT), was also assessed for subgroup versus without impairment. Results: According MoCA cut-off score 26, 45 had (PD-NCI) (54.22%) 38 cases (45.78%) (PD-CI). PD-CI group (p = 0.006 0.018, respectively). reclassified into AR tremor-dominant (TR) phenotype. more likely have (81.6%). Walking MDS-UPDRS score, IADL scores worse than PD-NCI. Stepwise linear regression analysis risk revealed higher scores, later onset, rMT values considered developing CI. Conclusions: Higher UPDRS as provide valuable insights further investigation potential considerations.

Language: Английский

Investigating the prevalence of the G2019S mutation in Parkinson's disease among a Libyan population DOI Creative Commons
Nuri Awayn, Sara A Hashish, S. A. Salem

et al.

Journal of Parkinson s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Parkinson's disease (PD) is a progressive neurodegenerative disorder influenced by both environmental and genetic risk factors. This study investigates the prevalence of LRRK2 G2019S mutation in Libyan population 140 PD patients 58 controls. Genetic analysis blood samples revealed that 19.5% carry mutation, indicating association with disease. The highlights as potential factor for Libya emphasizes importance screening better understanding management

Language: Английский

Citations

0
Cognitive Impairment-Associated Risk Factors of Parkinson’s Disease: A Hospital-Based Study in a Cohort of Upper Egypt Parkinson’s Patients DOI Creative Commons
Eman M. Khedr,

Khaled O. Aboshaera,

Ahmed A. Karim

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 459 - 459

Published: April 27, 2025

Background/Objectives: Cognitive impairment (CI) in Parkinson’s disease (PD) is a major burden and significantly affects patients’ quality of life. Previous studies found that older age at onset presence the akinetic–rigid (AR) subtype are associated with an increased likelihood CI PD. The present study aimed to assess factors related development Methods: Eighty-three PD patients were consecutively recruited. Demographic information, clinical details, Montreal cognitive assessment (MoCA), Movement Disorder Society Unified Disease Rating Scale (MDS-UPDRS), walking speed, instrumental activity daily living (IADL) assessed. Resting motor threshold (rMT), was also assessed for subgroup versus without impairment. Results: According MoCA cut-off score 26, 45 had (PD-NCI) (54.22%) 38 cases (45.78%) (PD-CI). PD-CI group (p = 0.006 0.018, respectively). reclassified into AR tremor-dominant (TR) phenotype. more likely have (81.6%). Walking MDS-UPDRS score, IADL scores worse than PD-NCI. Stepwise linear regression analysis risk revealed higher scores, later onset, rMT values considered developing CI. Conclusions: Higher UPDRS as provide valuable insights further investigation potential considerations.

Language: Английский

Citations

0