Human Cortico‐Cerebellar Dynamics During Motor Error Processing After Stroke DOI Creative Commons
Nitesh Singh Malan, Raghavan Gopalakrishnan, David A. Cunningham

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(8)

Published: May 15, 2025

ABSTRACT The cerebellum acts as a forward internal model to predict motor outcomes, compare them with sensory feedback, and generate prediction errors that refine accuracy. Our physiological understanding of cerebellar function during control derives predominantly from animal experiments clinical observations in patients disorders the or its connections cerebrum spinal cord. Here, we report human electrophysiology‐based investigation cerebello‐thalamo‐cortical pathway activity error detection correction. Participants performed computerized oddball task while synchronized electrophysiological recordings were collected dentate (DN) using depth electrodes scalp electroencephalography (EEG). involved moving 2‐D ball on screen toward predetermined target at 40% (standard trials) 20% (oddball their maximum voluntary contraction. Six participants completed an average 239 trials, trials randomly occurring 30% frequency. At cortex, exhibited significantly greater centro‐parietal positivity fronto‐centro‐parietal desynchronization correction, alpha low beta frequency bands. DN examination also revealed Lastly, showed cortico‐cerebellar coherence correction same bands bidirectional interaction between cortex DN. These findings expand cortico‐cerebello‐cortical physiology provide cues for designing interventions aimed alleviating functional burdens acquired injuries central nervous system.

Language: Английский

Human Cortico‐Cerebellar Dynamics During Motor Error Processing After Stroke DOI Creative Commons
Nitesh Singh Malan, Raghavan Gopalakrishnan, David A. Cunningham

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(8)

Published: May 15, 2025

ABSTRACT The cerebellum acts as a forward internal model to predict motor outcomes, compare them with sensory feedback, and generate prediction errors that refine accuracy. Our physiological understanding of cerebellar function during control derives predominantly from animal experiments clinical observations in patients disorders the or its connections cerebrum spinal cord. Here, we report human electrophysiology‐based investigation cerebello‐thalamo‐cortical pathway activity error detection correction. Participants performed computerized oddball task while synchronized electrophysiological recordings were collected dentate (DN) using depth electrodes scalp electroencephalography (EEG). involved moving 2‐D ball on screen toward predetermined target at 40% (standard trials) 20% (oddball their maximum voluntary contraction. Six participants completed an average 239 trials, trials randomly occurring 30% frequency. At cortex, exhibited significantly greater centro‐parietal positivity fronto‐centro‐parietal desynchronization correction, alpha low beta frequency bands. DN examination also revealed Lastly, showed cortico‐cerebellar coherence correction same bands bidirectional interaction between cortex DN. These findings expand cortico‐cerebello‐cortical physiology provide cues for designing interventions aimed alleviating functional burdens acquired injuries central nervous system.

Language: Английский

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