Genetic association and causal effects between inflammatory bowel disease and conjunctivitis DOI Creative Commons

Shuangqing Chang,

Qinghua Luo, Zhifang Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 4, 2024

Inflammatory bowel disease (IBD) is often clinically associated with conjunctivitis, which may result from genetic associations and causal effects.

Language: Английский

Shared genetic architecture of cortical thickness alterations in major depressive disorder and schizophrenia DOI

He Wang,

Qiyu Zhao,

Yijing Zhang

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 135, P. 111121 - 111121

Published: Aug. 22, 2024

Language: Английский

Citations

6
Genome-wide analysis identifies novel shared loci between depression and white matter microstructure DOI Creative Commons

Qiyu Zhao,

Shuo Wang,

Di Xiong

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Depression, a complex and heritable psychiatric disorder, is associated with alterations in white matter microstructure, yet their shared genetic basis remains largely unclear. Utilizing the largest available genome-wide association study (GWAS) datasets for depression (N = 674,452) microstructure 33,224), assessed through diffusion tensor imaging metrics such as fractional anisotropy (FA) mean diffusivity (MD), we employed linkage disequilibrium score regression method to estimate global correlations, local analysis of [co]variant approach pinpoint genomic regions conjunctional false discovery rate identify variants. Our findings revealed that showed significant correlations FA 37 MD 59 regions, while were weak. Variant-level identified 78 distinct loci jointly (25 novel loci) (35 loci), 41 (17 loci). Further analyses these exhibited both concordant discordant effect directions between traits, well overlapping hemispheric patterns architecture. Enrichment implicated biological processes related metabolism regulation. This provides evidence mixed-direction architecture microstructure. The identification specific pathways offers potential insights developing targeted interventions improve integrity alleviate depressive symptoms.

Language: Английский

Citations

0
Dissecting Schizophrenia Biology Using Pleiotropy with Cognitive Genomics DOI Creative Commons
Upasana Bhattacharyya,

Jibin John,

Todd Lencz

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Multigene overlap analysis of bipolar disorder subtypes and educational attainment DOI
Jianfei Zhang, Wanqi Wang, Yanmin Peng

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111358 - 111358

Published: April 1, 2025

Language: Английский

Citations

0
Genetic association and causal effects between inflammatory bowel disease and conjunctivitis DOI Creative Commons

Shuangqing Chang,

Qinghua Luo, Zhifang Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 4, 2024

Inflammatory bowel disease (IBD) is often clinically associated with conjunctivitis, which may result from genetic associations and causal effects.

Language: Английский

Citations

1