A multi-antigen vaccinia vaccine broadly protected mice against SARS-CoV-2 and influenza A virus while also targeting SARS-CoV-1 and MERS-CoV DOI Creative Commons
Nan Gao,

Tianhan Yang,

Lanlan Dong

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 28, 2024

Coronaviruses and influenza viruses are significant respiratory pathogens that cause severe disease burdens economic losses for society. Due to their diversity evolution, vaccines typically require periodic updating remain effective. An additional challenge is imposed by the possible coinfection of SARS-CoV-2 influenza, which could increase severity.

Language: Английский

The benefits of Lactiplantibacillus plantarum: from immunomodulator to vaccine vector DOI Creative Commons
Joshua Tobias,

Stefan Heinl,

Kristina Dendinovic

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106971 - 106971

Published: Jan. 5, 2025

Probiotics have been increasingly recognized for positively influencing many aspects of human health. Lactiplantibacillus plantarum (L. plantarum), a non-pathogenic bacterium, previously known as Lactobacillus plantarum, is one the lactic acid bacteria commonly used in fermentation. The probiotic properties L. highlighted its health benefits to humans when consumed adequate amounts. strains primarily enter body orally and alter intestinal microflora modulate immune responses their host; thereby benefiting Furthermore, use vaccine vectors delivering mucosal antigens has shown be promising strategy. These aspects, from Immunomodulation delivery by preclinical settings, are this review. Along these lines, construction recombinant strain expressing B cell multi-peptide, future immunity confer anti-tumor effect targeting Her-2/neu-overexpressing cancers local distal sites, also presented discussed.

Language: Английский

Citations

0
Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific Immunity DOI Creative Commons
Jaeyoung Park, Thomas Pho, Noopur Bhatnagar

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Intranasal vaccination is a desired route for protection against influenza viruses by mucosal and systemic immunity. However, the nasal mucosa impedes intranasal delivery of vaccines. Here, we formulated layer-by-layer (LBL) vaccine nanoparticles effective coating them with alternating mucoadhesive cationic chitosan muco-inert anionic CpG adjuvants. The nanoparticle cores were formed desolvating M2e antigen it hemagglutinin (HA) via biotin-streptavidin conjugation. LBL modification promoted interaction resident immune cells. administration significantly improved cellular humoral responses HA including high IgA titers, hallmark potent immunity persistence responses. Distinct trends antigen-specific observed different routes vaccination. enhanced conferred mice challenge prominently reduced viral demonstrating effectiveness nanoparticles.

Language: Английский

Citations

0
Multiple pathways to evaluate the immunoprotective effect of Turkeys Herpesvirus recombinant vaccine expressing HA of H9N2 DOI Creative Commons
Wenhao Yang, Jin Zhang, Jing Dai

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104335 - 104335

Published: Sept. 26, 2024

Language: Английский

Citations

0
A multi-antigen vaccinia vaccine broadly protected mice against SARS-CoV-2 and influenza A virus while also targeting SARS-CoV-1 and MERS-CoV DOI Creative Commons
Nan Gao,

Tianhan Yang,

Lanlan Dong

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 28, 2024

Coronaviruses and influenza viruses are significant respiratory pathogens that cause severe disease burdens economic losses for society. Due to their diversity evolution, vaccines typically require periodic updating remain effective. An additional challenge is imposed by the possible coinfection of SARS-CoV-2 influenza, which could increase severity.

Language: Английский

Citations

0