Novel insights into the N 6-methyladenosine modification on circRNA in cancer DOI Creative Commons
Qingling Xu, Yi Jia, Ying Liu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 19, 2025

Circular RNAs (circRNAs) are a class of non-coding (ncRNAs) generated through the reverse splicing mRNA precursors (pre-mRNAs). They possess unique loop structure and exhibit remarkable stability. CircRNAs have emerged as promising biomarkers for cancer, with specific circRNAs playing crucial roles in cancer drug discovery, treatment, resistance mechanisms. N6 methyl adenosine (m6A) represents most prevalent RNA modification eukaryotes. In 2017, researchers identified that m6A modifications also occur circRNAs, displaying characteristics. m6A-modified undergo reversible regulation mediated by enzymes involved pathways. These modified interact m6A-binding proteins, thereby influencing processes such alternative splicing, translation degradation. Some enhance their metabolism or facilitate nuclear export to cytoplasm interacting regulation. The study has gained great attention circRNA research due association various diseases. This review summarizes functional mechanisms regulated implications occurrence therapy, primary focus on genesis, regulatory mechanisms, biology diverse types cancers. Additionally, we explore potential application clinical treatment.

Language: Английский

Cancer mRNA vaccines: clinical application progress and challenges DOI
Hang Li,

Lequan Min,

Haotian Du

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 625, P. 217752 - 217752

Published: April 28, 2025

Language: Английский

Citations

0
Circular RNA, A Molecule with Potential Chemistry and Applications in RNA-based Cancer Therapeutics: An Insight into Recent Advances DOI Creative Commons

Zahra Shafaghat,

Safa Radmehr,

Saber Saharkhiz

et al.

Topics in Current Chemistry, Journal Year: 2025, Volume and Issue: 383(2)

Published: May 9, 2025

Language: Английский

Citations

0
Regulatory mechanism of circular RNAs in brain and neurodegenerative diseases DOI Creative Commons

Mandana Amelimojarad,

Melika Amelimojarad

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: May 16, 2025

Recent advancements in sequencing technology have allowed scientists to study the function and expression of different non-coding RNAs (ncRNAs). Circular (circRNAs) are increasingly recognized as prognostic diagnostic biomarkers. These classes ncRNAs closed loops that made from alternative mRNA splicing can be found large quantities with their evolutionarily conserved features across species. circRNAs derived both coding transcript regulate cellular proteins linear transcripts via ability act miRNA sponges at various levels. Different affect neurodegenerative disease pathogenesis such Alzheimer's (AD), altering a variety methods. However, there is still limited knowledge about brain cells. Therefore, this review, we will focus on role reveal new potential therapeutic target open door novel therapies improved management diseases.

Language: Английский

Citations

0
Novel insights into the N 6-methyladenosine modification on circRNA in cancer DOI Creative Commons
Qingling Xu, Yi Jia, Ying Liu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 19, 2025

Circular RNAs (circRNAs) are a class of non-coding (ncRNAs) generated through the reverse splicing mRNA precursors (pre-mRNAs). They possess unique loop structure and exhibit remarkable stability. CircRNAs have emerged as promising biomarkers for cancer, with specific circRNAs playing crucial roles in cancer drug discovery, treatment, resistance mechanisms. N6 methyl adenosine (m6A) represents most prevalent RNA modification eukaryotes. In 2017, researchers identified that m6A modifications also occur circRNAs, displaying characteristics. m6A-modified undergo reversible regulation mediated by enzymes involved pathways. These modified interact m6A-binding proteins, thereby influencing processes such alternative splicing, translation degradation. Some enhance their metabolism or facilitate nuclear export to cytoplasm interacting regulation. The study has gained great attention circRNA research due association various diseases. This review summarizes functional mechanisms regulated implications occurrence therapy, primary focus on genesis, regulatory mechanisms, biology diverse types cancers. Additionally, we explore potential application clinical treatment.

Language: Английский

Citations

0