Innovative strategies and approaches for enhancing performance in optical probe-based biosensors for point-of-care testing DOI
Birui Jin,

Chuyao Zhang,

Chuan Ma

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 176, P. 117775 - 117775

Published: May 20, 2024

Language: Английский

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles DOI
Jiapeng Zheng,

Xizhe Cheng,

Han Zhang

et al.

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13342 - 13453

Published: Sept. 27, 2021

Gold nanorods (NRs), pseudo-one-dimensional rod-shaped nanoparticles (NPs), have become one of the burgeoning materials in recent years due to their anisotropic shape and adjustable plasmonic properties. With continuous improvement synthetic methods, a variety been attached around Au NRs achieve unexpected or improved properties explore state-of-the-art technologies. In this review, we comprehensively summarize latest progress on NRs, most versatile NPs. We present representative overview advances strategies outline an extensive catalogue Au-NR-based heterostructures with tailored architectures special functionalities. The bottom-up assembly into preprogrammed metastructures is then discussed, as well design principles. also provide systematic elucidation different associated structures, followed by discussion promising applications various fields. finally discuss future research directions challenges NRs.

Language: Английский

Citations

433

Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid DOI Open Access
Zheyu Wang, Jingyi Luan, Anushree Seth

et al.

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 5(1), P. 64 - 76

Published: Jan. 22, 2021

Language: Английский

Citations

281

Recent Advances in Microfluidic Technology for Bioanalysis and Diagnostics DOI Creative Commons

Simon F. Berlanda,

Maximilian Breitfeld,

Claudius Dietsche

et al.

Analytical Chemistry, Journal Year: 2020, Volume and Issue: 93(1), P. 311 - 331

Published: Nov. 10, 2020

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTRecent Advances in Microfluidic Technology for Bioanalysis and DiagnosticsSimon F. BerlandaSimon BerlandaDepartment of Biosystems Science Engineering, ETH Zurich, CH-8093 SwitzerlandMore by Simon BerlandaView Biography, Maximilian BreitfeldMaximilian BreitfeldDepartment BreitfeldView Claudius L. DietscheClaudius DietscheDepartment DietscheView Petra S. Dittrich*Petra DittrichDepartment Switzerland*Email: [email protected]More DittrichView Biographyhttp://orcid.org/0000-0001-5359-8403Cite this: Anal. Chem. 2021, 93, 1, 311–331Publication Date (Web):November 10, 2020Publication History Published online10 November 2020Published inissue 12 January 2021https://doi.org/10.1021/acs.analchem.0c04366Copyright © 2020 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views15908Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (3 MB) Get e-AlertsSUBJECTS:3D printing,Biotechnology,Fluid dynamics,Liquids,Microfluidic devices e-Alerts

Language: Английский

Citations

231

Emerging ELISA derived technologies for in vitro diagnostics DOI
Ping Peng, Chang Liu, Zedong Li

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 152, P. 116605 - 116605

Published: March 25, 2022

Language: Английский

Citations

133

Ultrasensitive lateral-flow assays via plasmonically active antibody-conjugated fluorescent nanoparticles DOI Open Access
Rohit Gupta, Prashant Gupta, Sean Wang

et al.

Nature Biomedical Engineering, Journal Year: 2023, Volume and Issue: 7(12), P. 1556 - 1570

Published: Feb. 2, 2023

Language: Английский

Citations

107

Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point‐of‐Care: A Review of Recent Technologies DOI Creative Commons

Daria Semeniak,

Daniela Cruz, Ashutosh Chilkoti

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(34)

Published: March 25, 2022

Abstract Fluorescence‐based biosensors have widely been used in the life‐sciences and biomedical applications due to their low limit of detection a diverse selection fluorophores that enable simultaneous measurements multiple biomarkers. Recent research effort has made implement fluorescent into exploding field point‐of‐care testing (POCT), which uses cost‐effective strategies for rapid affordable diagnostic testing. However, fluorescence‐based assays often suffer from feeble signal at analyte concentrations, requires sophisticated, costly, bulky instrumentation maintain high sensitivity. Metal‐ metal oxide‐based nanostructures offer simple solution increase output generation enhancements close or oxide surface, shown improve excitation rate, quantum yield, photostability, radiation pattern fluorophores. This article provides an overview existing employ various fluorescence enhancement via demonstrated potential use as POCT. Biosensors using such planar substrates, freestanding nanoparticles, metal–dielectric–metal nanocavities are discussed with emphasis placed on technologies promise towards POCT without need centralized laboratories.

Language: Английский

Citations

102

Photonic crystal enhanced fluorescence emission and blinking suppression for single quantum dot digital resolution biosensing DOI Creative Commons
Yanyu Xiong, Qinglan Huang,

Taylor D. Canady

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 8, 2022

While nanoscale quantum emitters are effective tags for measuring biomolecular interactions, their utilities applications that demand single-unit observations limited by the requirements large numerical aperture (NA) objectives, fluorescence intermittency, and poor photon collection efficiency resulted from omnidirectional emission. Here, we report a nearly 3000-fold signal enhancement achieved through multiplicative effects of enhanced excitation, highly directional extraction, improvement, blinking suppression photonic crystal (PC) surface. The approach achieves single dot (QD) sensitivity with high signal-to-noise ratio, even when using low-NA lens an inexpensive optical setup. capability PC improves QDs on-time 15% to 85% ameliorating intermittency. We developed assay cancer-associated miRNA biomarkers single-molecule resolution, single-base mutation selectivity, 10-attomolar detection limit. Additionally, observed differential surface motion trajectories attachment stringency is altered changing base in cancer-specific sequence.

Language: Английский

Citations

88

Emerging biosensing and transducing techniques for potential applications in point-of-care diagnostics DOI Creative Commons
Junjie Qin, Wei Wang, Liqian Gao

et al.

Chemical Science, Journal Year: 2022, Volume and Issue: 13(10), P. 2857 - 2876

Published: Jan. 1, 2022

POC diagnostics are driven by the rapid advances in CRISPR, electrochemical and optical biosensors. Related emerging strategies described discussed from perspective of facilitating practical application biosensors testing.

Language: Английский

Citations

80

Plasmonic nanoparticle sensors: current progress, challenges, and future prospects DOI Creative Commons
Krishna Kant, Reshma Beeram, Yi Cao

et al.

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(12), P. 2085 - 2166

Published: Jan. 1, 2024

This comprehensive review summarizes the past, present, and future of plasmonic NP-based sensors in terms different sensing platforms, chemical biological analytes, expected technologies.

Language: Английский

Citations

19

Photonic Crystal Enhanced Microscopy on a 2D Photonic Crystal Surface DOI Creative Commons
Weinan Liu,

Siyan Li,

Edmond Chow

et al.

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Digital‐resolution biosensing based on resonant reflection from photonic crystals (PC) has demonstrated significant potential for detection of proteomic and genomic biomarkers in serology, infectious disease diagnostics, cancer diagnostics. An important intrinsic characteristic metamaterial surfaces is that enhanced electromagnetic fields are not uniformly distributed, resulting spatially variable light‐matter interactions with nanoparticle tags signal the presence biomarker molecules. In this work, spatial uniformity resonantly enhanced, surface‐confined a 1D PC compared 2D fourfold symmetry. When illuminated unpolarized light, simultaneously excited transverse electric magnetic modes present equally strong but complementary distribution, leading to >100% increased average near‐field intensity accompanied >50% compressed standard deviation PC. Utilizing Photonic Resonator Absorption Microscopy (PRAM) experimentally measure absorption ≈80 nm gold nanoparticles distributed upon surface, improvement observed when using Overall, AuNP contrast, uniformity, point spread function by PRAM performed surface.

Language: Английский

Citations

2