Designing next‐generation immune cell therapies with nanomaterials DOI Creative Commons
Kangfu Chen,

Wenhan Wang,

Zongjie Wang

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Immune Cellular Therapies (ICT) have revolutionized the treatment of blood cancer and are beginning to show positive outcomes in treating solid tumors. Despite these successes, ICT faces significant challenges, including tumor accessibility, lengthy manufacturing turnaround, limited long‐term effectiveness. Recent advancements nanomaterials, particularly nanoparticles, offered promising solutions issues. This perspective introduces current pipeline with a focus on tumors showcases recent nanomaterial‐mediated practices enhance ICT. These efforts include use cell‐targeting magnetic nanoparticles for non‐invasive target identification, lipid vivo immune cell stimulation, as well nanoparticle‐mediated gene editing cytokine delivery fitness. By better integrating into design pipelines, we envision that next generation could be faster, more efficient, capable targeting broad spectrum cancers inflammatory diseases.

Language: Английский

Designing next‐generation immune cell therapies with nanomaterials DOI Creative Commons
Kangfu Chen,

Wenhan Wang,

Zongjie Wang

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Immune Cellular Therapies (ICT) have revolutionized the treatment of blood cancer and are beginning to show positive outcomes in treating solid tumors. Despite these successes, ICT faces significant challenges, including tumor accessibility, lengthy manufacturing turnaround, limited long‐term effectiveness. Recent advancements nanomaterials, particularly nanoparticles, offered promising solutions issues. This perspective introduces current pipeline with a focus on tumors showcases recent nanomaterial‐mediated practices enhance ICT. These efforts include use cell‐targeting magnetic nanoparticles for non‐invasive target identification, lipid vivo immune cell stimulation, as well nanoparticle‐mediated gene editing cytokine delivery fitness. By better integrating into design pipelines, we envision that next generation could be faster, more efficient, capable targeting broad spectrum cancers inflammatory diseases.

Language: Английский

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