Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: April 17, 2024
Ovarian cancer (OC) is the deadliest malignancy in gynecology, but mechanism of its initiation and progression poorly elucidated. Disulfidptosis a novel discovered type regulatory cell death. This study aimed to develop disulfidptosis-related prognostic signature (DRPS) for OC explore effects potential treatment by risk stratification.
Language: Английский
Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)
Published: May 31, 2023
Disulfidptosis, a new form of cell death triggered by disulfide stress, is characterized the collapse cytoskeleton proteins and F-actin due to intracellular accumulation disulfides. This discovery will eventually aid in development therapeutic strategies against cancer.
Language: Английский
Citations
101
Cancer Genetics, Journal Year: 2023, Volume and Issue: 278-279, P. 91 - 103
Published: Oct. 10, 2023
Language: Английский
Citations
66
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Aug. 1, 2023
Abstract Disulfidptosis is a newly discovered form of cell death. Not yet clearly classified as programmed death or accidental This study aimed to create novel disulfidptosis-related lncRNA index (DLI) that can be used predict survival and chemotherapy drugs sensitivity in patients with cervical cancer. First all, we found lncRNAs associated disulfidptosis between cancer tissues normal tissues. By LASSO-Cox analysis, overlapping were then construct disulfidptosis, which served the prognosis CC, especially sensitivity. ROC curves PCA based on DLI clinical signatures developed demonstrated have good predictive potential. In addition, differences immune subset infiltration checkpoint expression high-DLI low-DLI groups analyzed, investigated relationship tumor mutation burden (TMB). summary, constructed prediction disulfidptosis. has important implications, including improving value providing biomarker for guiding individualized treatment.
Language: Английский
Citations
29
Aging, Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 7, 2023
Disulfidptosis is a new cell death model caused by accumulating intracellular disulfides bonding to actin cytoskeleton proteins. This study aimed investigate the expression and prognostic value of disulfidptosis-related genes (DRGs) in lung adenocarcinoma (LUAD). The data profiles scRNA-seq were collected from TCGA GEO databases. different expressions DRGs between normal LUAD tissues compared. LASSO analysis multivariate Cox regression utilized develop for prognosis evaluation LUAD. model's predictive accuracy was evaluated with area under receiver operating characteristic curve (AUC) C-index. Survival analysis, univariate used assessing model. ScRNA-seq analyzed "Seurat" "Monocle 2" packages. There significant differences 22 tumor tissues. A five (ACTB, FLNB, NCKAP1, SLC3A2, SLC7A11) constructed. AUC C-index significantly higher than that based on clinical parameters. demonstrated risk score an independent predictor. In study, we identified 14 clusters 11 types. Clusters 2, 8, 13 annotated into Epithelial cells. SLC7A11 NCKAP1 ACTB expressed most abundantly cells, Endothelial Naive CD4 T, respectively. We explored constructed model, which stable reliable predicting prognosis.
Language: Английский
Citations
24
npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)
Published: March 27, 2024
Abstract Regulated cell death (RCD) plays a pivotal role in various biological processes, including development, tissue homeostasis, and immune response. However, comprehensive assessment of RCD status its associated features at the pan-cancer level remains unexplored. Furthermore, despite significant advancements checkpoint inhibitors (ICI), only fraction cancer patients currently benefit from treatments. Given emerging evidence linking ICI efficacy, we hypothesize that could serve as promising biomarker for predicting response overall survival (OS) with malignant tumors. We defined levels score, allowing us to delineate landscape across 30 types, 29 normal tissues bulk, 2,573,921 cells 82 scRNA-Seq datasets. By leveraging large-scale datasets, aimed establish positive association immunity identify signature. Utilizing 7 machine-learning algorithms 18 cohorts, developed an signature (RCD.Sig) Additionally, employed 101 combinations 10 construct novel survival-related (RCD.Sur.Sig) OS. obtained CRISPR data potential therapeutic targets. Our study presents integrative framework assessing reveals strong connection between effectiveness. Moreover, two clinically applicable signatures targets
Language: Английский
Citations
13
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 8, 2024
Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis maintaining redox balance countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) soybean phospholipid (SP) as pyroptosis promoters (Pd
Language: Английский
Citations
13
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 9, 2024
Abstract Background Disulfidptosis is a type of programmed cell death caused by excessive cysteine-induced disulfide bond denaturation leading to actin collapse. Liver cancer has poor prognosis and requires more effective intervention strategies. Currently, the prognostic therapeutic value disulfidptosis in liver not clear. Methods We investigated features 16 disulfidptosis-related genes (DRGs) HCC patients TCGA classified into two pattern clusters consensus clustering analysis. Then, we constructed model using LASSO Cox regression. Next, microenvironment drug sensitivity were evaluated. Finally, used qPCR functional analysis verify reliability hub DRGs. Results Most DRGs showed significantly higher expression tissues than adjacent tissues. Our model, DRG score, can well predict survival patients. There significant differences survival, microenvironment, effects immunotherapy, between high- low-DRG score groups. Ultimately, demonstrated that few have differential mRNA cells normal protective gene LCAT inhibit metastasis vitro. Conclusion established novel risk based on scores patient prognosis, immunotherapy efficacy, which provides new insight relationship valuable assistance for personalized treatment HCC.
Language: Английский
Citations
9
APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown
Published: June 17, 2024
Abstract Disulfidptosis is a novel form of cell death that distinguishable from established programmed pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis. This process characterized by the rapid depletion nicotinamide adenine dinucleotide phosphate (NADPH) in cells high expression solute carrier family 7 member 11 (SLC7A11) during glucose starvation, resulting abnormal cystine accumulation, which subsequently induces andabnormal disulfide bond formation actin cytoskeleton proteins, culminating network collapse disulfidptosis. review aimed to summarize underlying mechanisms, influencing factors, comparisons with traditional pathways, associations related diseases, application prospects, future research directions
Language: Английский
Citations
9
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(7), P. 2815 - 2853
Published: April 24, 2024
Regulated cell death (RCD) is a controlled form of orchestrated by one or more cascading signaling pathways, making it amenable to pharmacological intervention. RCD subroutines can be categorized as apoptotic non-apoptotic and play essential roles in maintaining homeostasis, facilitating development, modulating immunity. Accumulating evidence has recently revealed that evasion frequently the primary cause tumor survival. Several have garnered attention promising cancer therapies due their ability induce regression prevent relapse, comparable apoptosis. Moreover, they offer potential solutions for overcoming acquired resistance tumors toward drugs. With an increasing understanding underlying mechanisms governing these subroutines, growing number small-molecule compounds targeting single multiple pathways been discovered, providing novel strategies current therapy. In this review, we comprehensively summarized regulatory emerging mainly including autophagy-dependent death, ferroptosis, cuproptosis, disulfidptosis, necroptosis, pyroptosis, alkaliptosis, oxeiptosis, parthanatos, mitochondrial permeability transition (MPT)-driven necrosis, entotic NETotic lysosome-dependent immunogenic (ICD). Furthermore, focused on discussing related compounds. brief, insightful findings may provide valuable guidance investigating individual collaborative approaches towards different ultimately driving discovery target significantly enhance future therapeutics.
Language: Английский
Citations
8
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Abstract Gaudichaudione H (GH) is a naturally occurring small molecular compound derived from Garcinia oligantha Merr . (Clusiaceae), but the full pharmacological functions remain unclear. Herein, potential of GH in disulfidptosis regulation, novel form programmed cell death induced by disulfide stress explored. The omics results indicated that NRF2 signaling could be significantly activated GH. targets are associated with hepatocarcinogenesis and death. Moreover, both glutathione (GSH) metabolism NADP + ‐NADPH affected GH, indicating regulation. It also observed enhanced sensitivity hepatocellular carcinoma (HCC) cells to disulfidptosis, which dependent on activation NRF2‐SLC7A11 pathway. increased levels promoted transcription target gene, SLC7A11, through autophagy‐mediated non‐canonical mechanism. Under condition glucose starvation, GH‐induced upregulation SLC7A11 aggravated uptake cysteine, disturbance GSH synthesis, depletion NADPH, accumulation molecules, ultimately leading formation bonds between different cytoskeleton proteins eventually. Collectively, findings underscore role promoting cancer thereby offering promising avenue for treatment drug‐resistant HCC clinical settings.
Language: Английский
Citations
1