Basement membranes in lung metastasis growth and progression DOI Creative Commons

Irene Torre-Cea,

Patricia Berlana-Galán,

Elena Guerra-Paes

et al.

Matrix Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The lung is a highly vascularized tissue that often harbors metastases from various extrathoracic malignancies. Lung parenchyma consists of complex network alveolar epithelial cells and microvessels, structured within an architecture defined by basement membranes. Consequently, understanding the role extracellular matrix (ECM) in growth essential to uncover biology this pathology developing targeted therapies. These membranes play critical progression metastases, influencing multiple stages metastatic cascade, acquisition aggressive phenotype intravasation, extravasation colonization secondary sites. This review examines biological composition membranes, focusing on their core components-collagens, fibronectin, laminin-and specific roles cancer progression. Additionally, we discuss function integrins as primary mediators cell adhesion signaling between tumor cells, matrix, well implications for lung. We also explore vascular co-option (VCO) form resistance linked vasculature. Finally, covers current clinical therapies targeting adhesion, remodeling, development, aiming improve precision effectiveness treatments against metastases.

Language: Английский

Tumor microenvironment as a complex milieu driving cancer progression: a mini review DOI Creative Commons
Zhengrui Li, Jing Li,

Xiaolei Bai

et al.

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

Citations

18
Enhancing Gastrointеstinal (GI) Cancer Therapies with Ganoderma Lucidum: A Review of Mechanisms and Efficacy DOI Creative Commons
Kaushal Kishor Sharma, Saksham Gupta, Prakash S. Bisen

et al.

Published: Jan. 1, 2025

Gastrointestinal (GI) cancer stands as a global health challenge, necessitating effective therapeutic approaches with minimal adverse еffеct. This review delves into the potential of Ganoderma lucidum, macro fungus, commonly recognized for its medicinal properties, in traditional Chinese medicine. Macro fungus acts promising adjunct treating gastrointestinal cancer. The bioactive compounds from lucidum are polysaccharides, triterpenes, and proteins demonstrating anti-tumor activities by modulating key cellular mechanisms such proliferation, apoptosis, metastasis, autophagy. elucidates underpinning G. lucidum's anti-GI properties through an extensive exploration available literature. Furthermore, it provides understanding clinical applications shedding light on complementary option realm both western comprehensive analysis presented herein aims to serve valuable guide future studies endeavors, fostering dееpеr lucidum’s role preventing GI

Language: Английский

Citations

0
A highly effective self-supplying photosensitizer drug for deep-tissue metastatic tumours treatment DOI Creative Commons
Zhengze Yu, Hanxiang Li, Mingchao Xia

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract Due to the inherent defects of photodynamic therapy (PDT), its application in treatment deep-tissue metastatic tumours remains challenging. To extend applicability PDT, a novel chemiluminescent photosensitizer, Cy7-EOM, was developed by covalently coupling photosensitizer Cy7 with peroxycatechol derivative and encapsulating it within folate-modified disulfide-containing nano-micelles. Upon targeted delivery selective release, positive charged Cy7-EOM would target mitochondria efficiently generate singlet oxygen (1O2) via intramolecular chemiluminescence resonance energy transfer (CRET) endogenous H2O2, directly inducing mitochondrial damage cell apoptosis, realizing an efficient PDT for tumours. Remarkably, covalent linkage between donor acceptor greatly reduces distance, significantly enhancing CRET efficiency. Moreover, tumour-specific decomposition nano-micelles prevents aggregation-induced quenching mitigates diffusion barrier 1O2, while normal tissues integrality shields lethal effects 1O2. This method provides new strategy transforming adjuvant photosensitizers into direct therapeutic drugs, significant potential clinical

Language: Английский

Citations

0
Epithelial-mesenchymal transition in cancer: A focus on itraconazole, a hedgehog inhibitor DOI Creative Commons
Aniruddha Murahar Kulkarni, Prasanna Kumar Reddy Gayam,

Beena Thazhackavayal Baby

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189279 - 189279

Published: Feb. 1, 2025

Cancer, and the resulting mortality from it, is an ever-increasing concern in global health. Cancer stems metastatic progression of disease, by dissemination tumor cells. Epithelial-Mesenchymal Transition, major hypothesis purported to be origin metastasis, confers mesenchymal phenotype epithelial cells a variety contexts, physiological pathological. EMT cancer leads rise cancer-stem-like cells, drug resistance, relapse, malignancy. Inhibition could potentially attenuate mortality. While novel molecules for inhibiting are underway, repurposing drugs also being considered as viable strategy. In this review, Itraconazole focused upon, repurposed molecule mitigate EMT. known inhibit Hedgehog signaling, light shed upon existing evidence, well questions remaining answered.

Language: Английский

Citations

0
Spheroid‐on‐a‐Chip Platforms for Tumor Microenvironment and Drug Development DOI Open Access

Pierre Claver Uzabakiriho,

Jiajun Fan,

Benedictor Alexander Nguchu

et al.

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Despite significant advancements in oncology research and therapeutic interventions, cancer continues to be the leading cause of mortality worldwide. The key challenge addressing this pressing issue lies lack precision diagnosis a limited understanding nature how tumor microenvironment responds interventions. Research focusing on impact (TME) heterogeneity response drugs is crucial ensure efficient therapy. Conventional models exhibit constraints, including inability accurately imitate tumors’ complex 3D architecture dynamic microenvironment. Recent developments Spheroid‐On‐a‐Chip (SoC) technology provide alternative, offering closer that human tissue. This review explores recent SoC modeling, highlighting spheroid formation mechanisms techniques. applications platform mimic essential features their potential role anticancer drug development are summarized. advantages challenges technologies behind devices compared traditional vitro further discussed. Lastly, future directions for transforming improving suggested.

Language: Английский

Citations

0
Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention DOI Creative Commons

Lin Tang,

Peng Shen, Xiaoying Zhuang

et al.

MedComm – Oncology, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 17, 2025

ABSTRACT Metastasis remains a leading cause of cancer‐related deaths, defined by complex, multi‐step process in which tumor cells spread and form secondary growths distant tissues. Despite substantial progress understanding metastasis, the molecular mechanisms driving this development effective therapies remain incompletely understood. Elucidating pathways governing metastasis is essential for discovery innovative therapeutic targets. The rapid advancements sequencing technologies expansion biological databases have significantly deepened our drivers associated drug resistance. This review focuses on particularly roles genetic mutations, epigenetic changes, post‐translational modifications progression. We also examine how microenvironment influences metastatic behavior explore emerging strategies, including targeted immunotherapies. Finally, we discuss future research directions, stressing importance novel treatment approaches personalized strategies to overcome improve patient outcomes. By integrating contemporary insights into basis innovation, provides comprehensive framework guide clinical cancer.

Language: Английский

Citations

0
IL-1β+ macrophages and the control of pathogenic inflammation in cancer DOI
Nicoletta Caronni, Federica La Terza,

Luca Frosio

et al.

Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
VRK1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma mediated by SNAI1 via phosphorylating CHD1L DOI Creative Commons

Jing Li,

Zan Song,

Xue Dong

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 15, 2025

Abstract Vaccinia-related kinase 1 (VRK1) is involved in numerous cellular processes, including DNA repair, cell cycle and proliferation. However, its roles molecular mechanism underlying the progression of hepatocellular carcinoma (HCC) are yet largely unexplored. Here, we demonstrated that VRK1 expression elevated HCC tumor tissues, which associated with high stage poor prognosis patients. In vitro vivo experiments manifested overexpression significantly promotes proliferation, colony formation, migration growth by inducing epithelial-mesenchymal transition (EMT) program. Mechanistically, immunoprecipitation combined mass spectrometry analysis determined interacts CHD1L, mediates phosphorylation CHD1L at serine 122 site. RNA-seq revealed one key downstream target genes SNAI1 , EMT process progression. Furthermore, upregulates through phosphorylating CHD1L. conclusion, these findings suggested VRK1/CHD1L/SNAI1 axis acts as a cancer-driving pathway to promote proliferation HCC, indicating targeting may be an attractive therapeutic strategy HCC.

Language: Английский

Citations

0
Lung-specific metastasis: the coevolution of tumor cells and lung microenvironment DOI Creative Commons

Guixiu Xiao,

Xinmin Wang,

Zihan Xu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 16, 2025

Language: Английский

Citations

0
Concentration-Dependent Pleiotropic Effects of Thymosin Beta4 and Cofilin on the Migratory Activity of Carcinoma Cells DOI Creative Commons
Abdulatif Al Haj,

Kamila Ćwikłowska,

Antonina Joanna Mazur

et al.

International Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 5(2), P. 16 - 16

Published: April 18, 2025

Background/Objectives: Tumor cell migration depends on the actin cytoskeleton modified by actin-binding proteins (ABPs). Overexpression of cofilin or thymosin beta4 (Tß4) has been correlated with an increase decrease in their migratory activity, respectively. Methods: Immunostaining tumor cells and transfection EGFP-tagged bicistronic vectors leading to independent expression EGFP Tß4. Determination transwell agarose drop assay. Results: We modulated intracellular concentrations Tß4 two colon (3LNLN EB3) one breast carcinoma (MDA-MB-231) line analyzed activity. Increasing wild-type did not alter whereas constitutively active S3A–cofilin mutant elevated migration. Transfection up- downregulation showed that MDA-MB-231 3LNLN responded a migration, Exposure increasing extracellular Tβ4 (or His-tagged Tß4) induced biphasic response being highest around 0.24 µM decreased at higher exposed anti-His antibody indicated its uptake co-localizing integrin-linked kinase attachment points. Furthermore, exposure led increased phosphorylation AKT1/2 secretion matrix metalloproteases. These effects were abrogated after 2.8 His-Tß4, also inducing apoptosis number cells. Conclusions: can be inhibited high

Language: Английский

Citations

0