Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(12), P. 6425 - 6429
Published: Jan. 18, 2021
Abstract
Metal‐catalyzed
hydrogenation
is
an
effective
method
to
transform
readily
available
arenes
into
saturated
motifs,
however,
current
strategies
are
limited
the
formation
of
C−H
and
N−H
bonds.
The
stepwise
addition
hydrogen
yields
reactive
unsaturated
intermediates
that
rapidly
reduced.
In
contrast,
interruption
complete
by
further
functionalization
offers
great
potential
for
increasing
chemical
complexity
in
a
single
reaction
step.
Overcoming
tenet
full
reduction
arene
has
been
seldom
demonstrated.
this
work
we
report
synthesis
sought‐after,
enantioenriched
δ‐lactams
from
oxazolidinone‐substituted
pyridines
water
interrupted
mechanism.
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(31), P. 10460 - 10476
Published: Jan. 31, 2019
Arene
hydrogenation
provides
direct
access
to
saturated
carbo-
and
heterocycles
thus
its
strategic
application
may
be
used
shorten
synthetic
routes.
This
powerful
transformation
is
widely
applied
in
industry
expected
facilitate
major
breakthroughs
the
sciences.
The
ability
overcome
aromaticity
while
controlling
diastereo-,
enantio-,
chemoselectivity
central
use
of
preparation
complex
molecules.
In
general,
multisubstituted
arenes
yields
predominantly
cis
isomer.
Enantiocontrol
imparted
by
chiral
auxiliaries,
Brønsted
acids,
or
transition-metal
catalysts.
Recent
studies
have
demonstrated
that
highly
chemoselective
transformations
are
possible.
Such
methods
underlying
strategies
reviewed
herein,
with
an
emphasis
on
synthetically
useful
examples
employ
readily
available
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2937 - 2937
Published: Feb. 2, 2023
Piperidines
are
among
the
most
important
synthetic
fragments
for
designing
drugs
and
play
a
significant
role
in
pharmaceutical
industry.
Their
derivatives
present
more
than
twenty
classes
of
pharmaceuticals,
as
well
alkaloids.
The
current
review
summarizes
recent
scientific
literature
on
intra-
intermolecular
reactions
leading
to
formation
various
piperidine
derivatives:
substituted
piperidines,
spiropiperidines,
condensed
piperidinones.
Moreover,
applications
natural
piperidines
were
covered,
latest
advances
discovery
biological
evaluation
potential
containing
moiety.
This
is
designed
help
both
novice
researchers
taking
their
first
steps
this
field
experienced
scientists
looking
suitable
substrates
synthesis
biologically
active
piperidines.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(3), P. 1122 - 1246
Published: Jan. 2, 2024
Dearomatization
reactions
have
become
fundamental
chemical
transformations
in
organic
synthesis
since
they
allow
for
the
generation
of
three-dimensional
complexity
from
two-dimensional
precursors,
bridging
arene
feedstocks
with
alicyclic
structures.
When
those
processes
are
applied
to
pyridines,
quinolines,
and
isoquinolines,
partially
or
fully
saturated
nitrogen
heterocycles
formed,
which
among
most
significant
structural
components
pharmaceuticals
natural
products.
The
inherent
challenge
lies
low
reactivity
heteroaromatic
substrates,
makes
dearomatization
process
thermodynamically
unfavorable.
Usually,
connecting
event
irreversible
formation
a
strong
C–C,
C–H,
C–heteroatom
bond
compensates
energy
required
disrupt
aromaticity.
This
aromaticity
breakup
normally
results
1,2-
1,4-functionalization
heterocycle.
Moreover,
combination
these
subsequent
tandem
stepwise
protocols
allows
multiple
heterocycle
functionalizations,
giving
access
complex
molecular
skeletons.
aim
this
review,
covers
period
2016
2022,
is
update
state
art
nucleophilic
dearomatizations
showing
extraordinary
ability
dearomative
methodology
indicating
their
limitations
future
trends.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(15), P. 4996 - 5012
Published: Jan. 1, 2023
This
review
summarises
the
state-of-the-art
in
transition-metal
catalysed
asymmetric
hydrogenation
of
(hetero)arenes
and
highlights
recent
advances
with
a
special
focus
on
sustainability
while
also
addressing
its
shortcomings.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 5864 - 5871
Published: Feb. 20, 2024
Sulfur,
alongside
oxygen
and
nitrogen,
holds
a
prominent
position
as
one
of
the
key
heteroatoms
in
nature
medicinal
chemistry.
Its
significance
stems
from
its
ability
to
adopt
different
oxidation
states,
rendering
it
valuable
both
polarity
handle
hydrogen
bond
donor/acceptor.
Nevertheless,
poisonous
free
electron
pairs
makes
sulfur
containing
substrates
inaccessible
for
many
catalytic
protocols.
Strong
(at
low
temperatures)
irreversible
chemisorption
catalyst's
surface
is
particular
detrimental
heterogeneous
catalysts,
possessing
only
few
catalytically
active
sites.
Herein,
we
present
novel
Ru-S
catalyst
that
tolerates
multiple
functionalities,
including
thioethers,
thiophenes,
sulfoxides,
sulfones,
sulfonamides,
sulfoximines,
hydrogenation
quinolines.
The
utility
products
was
further
demonstrated
by
subsequent
diversifications
functionalities.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(17), P. 11866 - 11875
Published: April 15, 2024
The
available
methods
of
chemical
synthesis
have
arguably
contributed
to
the
prevalence
aromatic
rings,
such
as
benzene,
toluene,
xylene,
or
pyridine,
in
modern
pharmaceuticals.
Many
sp
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(40), P. 17408 - 17412
Published: June 16, 2020
Abstract
Herein,
we
report
the
synthesis
of
specific
silica‐supported
Co/Co
3
O
4
core–shell
based
nanoparticles
prepared
by
template
cobalt‐pyromellitic
acid
on
silica
and
subsequent
pyrolysis.
The
optimal
catalyst
material
allows
for
general
selective
hydrogenation
pyridines,
quinolines,
other
heteroarenes
including
acridine,
phenanthroline,
naphthyridine,
quinoxaline,
imidazo[1,2‐a]pyridine,
indole
under
comparably
mild
reaction
conditions.
In
addition,
recycling
these
Co
their
ability
dehydrogenation
catalysis
are
showcased.
