ACS Catalysis,
Journal Year:
2020,
Volume and Issue:
10(20), P. 11712 - 11738
Published: Sept. 11, 2020
Aminium
radical
cations
have
been
extensively
studied
as
electrophilic
aminating
species
that
readily
participate
in
C–N
bond
forming
processes
with
alkenes
and
arenes.
However,
their
utility
synthesis
has
limited,
generation
required
unstable,
reactive
starting
materials
harsh
reaction
conditions.
Visible-light
photoredox
catalysis
emerged
a
platform
for
the
mild
production
of
aminium
from
either
unfunctionalized
or
N-functionalized
amines.
This
Perspective
covers
recent
synthetic
methods
rely
on
photocatalytic
formation,
specifically
context
alkene
hydroamination,
arene
C–H
amination,
mesolytic
cleavage
alkoxyamines.
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
120(5), P. 2613 - 2692
Published: Feb. 17, 2020
Transition-metal
catalyzed
reactions
that
are
able
to
construct
complex
aliphatic
amines
from
simple,
readily
available
feedstocks
have
become
a
cornerstone
of
modern
synthetic
organic
chemistry.
In
light
the
ever-increasing
importance
across
range
chemical
sciences,
this
review
aims
provide
concise
overview
transition-metal
approaches
alkylamine
synthesis
and
their
functionalization.
Selected
examples
amine
bond
forming
include:
(a)
hydroamination
hydroaminoalkylation,
(b)
C(sp3)–H
functionalization,
(c)
visible-light-mediated
photoredox
catalysis.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 1925 - 2016
Published: Sept. 29, 2021
The
fields
of
C–H
functionalization
and
photoredox
catalysis
have
garnered
enormous
interest
utility
in
the
past
several
decades.
Many
different
scientific
disciplines
relied
on
strategies
including
natural
product
synthesis,
drug
discovery,
radiolabeling,
bioconjugation,
materials,
fine
chemical
synthesis.
In
this
Review,
we
highlight
use
reactions.
We
separate
review
into
inorganic/organometallic
catalysts
organic-based
catalytic
systems.
Further
subdivision
by
reaction
class─either
sp2
or
sp3
functionalization─lends
perspective
tactical
for
these
methods
synthetic
applications.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2752 - 2906
Published: Aug. 10, 2021
Photoinduced
chemical
transformations
have
received
in
recent
years
a
tremendous
amount
of
attention,
providing
plethora
opportunities
to
synthetic
organic
chemists.
However,
performing
photochemical
transformation
can
be
quite
challenge
because
various
issues
related
the
delivery
photons.
These
challenges
barred
widespread
adoption
steps
industry.
past
decade,
several
technological
innovations
led
more
reproducible,
selective,
and
scalable
photoinduced
reactions.
Herein,
we
provide
comprehensive
overview
these
exciting
advances,
including
flow
chemistry,
high-throughput
experimentation,
reactor
design
scale-up,
combination
photo-
electro-chemistry.
Chemical Reviews,
Journal Year:
2019,
Volume and Issue:
119(24), P. 12491 - 12523
Published: Nov. 22, 2019
Transition
metal-mediated
formation
of
C-N
bonds
is
an
essential
synthetic
methodology.
The
discovery
the
Chan-Lam
amination
provided
a
bond
forming
process
that
was
mild,
convenient,
and
inexpensive,
offering
alternative
to
complementary
methods
using
other
transition
metals
(TMs).
Over
past
20
years,
this
reaction
has
seen
considerable
development
in
its
scope
application,
uptake
into
industry,
understanding
mechanism.
This
review
provides
account
amination,
highlighting
progress
notable
examples
application
since
2011.
Focus
given
evolution
mechanistic
selected
applications
methodology
within
medicinal
chemistry.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 766 - 897
Published: Dec. 22, 2020
Recent
developments
and
future
prospects
of
visible-light
photocatalysis
in
the
late-stage
functionalization
pharmaceuticals
natural
bioactive
compounds.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(8), P. 4237 - 4352
Published: Jan. 24, 2023
The
emergence
of
modern
photocatalysis,
characterized
by
mildness
and
selectivity,
has
significantly
spurred
innovative
late-stage
C–H
functionalization
approaches
that
make
use
low
energy
photons
as
a
controllable
source.
Compared
to
traditional
strategies,
photocatalysis
paves
the
way
toward
complementary
and/or
previously
unattainable
regio-
chemoselectivities.
Merging
compelling
benefits
with
workflow
offers
potentially
unmatched
arsenal
tackle
drug
development
campaigns
beyond.
This
Review
highlights
photocatalytic
strategies
small-molecule
drugs,
agrochemicals,
natural
products,
classified
according
targeted
bond
newly
formed
one.
Emphasis
is
devoted
identifying,
describing,
comparing
main
mechanistic
scenarios.
draws
critical
comparison
between
established
ionic
chemistry
photocatalyzed
radical-based
manifolds.
aims
establish
current
state-of-the-art
illustrate
key
unsolved
challenges
be
addressed
in
future.
authors
aim
introduce
general
readership
functionalization,
specialist
practitioners
evaluation
methodologies,
potential
for
improvement,
future
uncharted
directions.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(15), P. 12544 - 12747
Published: July 17, 2022
1,1,1,3,3,3-Hexafluoroisopropanol
(HFIP)
is
a
polar,
strongly
hydrogen
bond-donating
solvent
that
has
found
numerous
uses
in
organic
synthesis
due
to
its
ability
stabilize
ionic
species,
transfer
protons,
and
engage
range
of
other
intermolecular
interactions.
The
use
this
exponentially
increased
the
past
decade
become
choice
some
areas,
such
as
C–H
functionalization
chemistry.
In
review,
following
brief
history
HFIP
an
overview
physical
properties,
literature
examples
reactions
using
or
additive
are
presented,
emphasizing
effect
each
reaction.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2907 - 2980
Published: Sept. 24, 2021
In
the
pursuit
of
new
pharmaceuticals
and
agrochemicals,
chemists
in
life
science
industry
require
access
to
mild
robust
synthetic
methodologies
systematically
modify
chemical
structures,
explore
novel
space,
enable
efficient
synthesis.
this
context,
photocatalysis
has
emerged
as
a
powerful
technology
for
synthesis
complex
often
highly
functionalized
molecules.
This
Review
aims
summarize
published
contributions
field
from
industry,
including
research
industrial-academic
partnerships.
An
overview
developed
strategic
applications
synthesis,
peptide
functionalization,
isotope
labeling,
both
DNA-encoded
traditional
library
is
provided,
along
with
summary
state-of-the-art
photoreactor
effective
upscaling
photocatalytic
reactions.
