Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 19, 2024
Abstract
Visible-light
photocatalysis
has
evolved
as
a
powerful
technique
to
enable
controllable
radical
reactions.
Exploring
unique
photocatalytic
mode
for
obtaining
new
chemoselectivity
and
product
diversity
is
of
great
significance.
Herein,
we
present
photo-induced
chemoselective
1,2-diheteroarylation
unactivated
alkenes
utilizing
halopyridines
quinolines.
The
ring-fused
azaarenes
serve
not
only
substrate,
but
also
potential
precursors
halogen-atom
abstraction
pyridyl
generation
in
this
photocatalysis.
As
complement
metal
catalysis,
process
with
mild
redox
neutral
conditions
assembles
two
different
heteroaryl
groups
into
regioselectively
contribute
broad
substrates
scope.
obtained
products
containing
aza-arene
units
permit
various
further
diversifications,
demonstrating
the
synthetic
utility
protocol.
We
anticipate
that
protocol
will
trigger
advancement
alkyl/aryl
halides
activation.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(32)
Published: June 15, 2023
We
disclose
a
Ni-catalyzed
regioselective
dialkylation
reaction
of
alkenylarenes
with
α-halocarbonyls
and
alkylzinc
reagents.
The
produces
γ-arylated
alkanecarbonyl
compounds
the
generation
two
new
C(sp
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1575 - 1583
Published: Jan. 16, 2024
The
example
of
iron-catalyzed
reductive
fluoroalkylalkenylation
unactivated
alkenes
has
been
disclosed,
affording
the
stereodefined
homoallylic
fluoroalkanes
with
high
efficiency
and
regioselectivity.
This
three-component
cross-electrophile
coupling
features
directing
groups
free,
good
functional
group
tolerance,
broad
substrate
scope,
late-stage
difunctionalization
biorelevant
molecules.
Moreover,
this
protocol
sheds
light
on
distinct
reactivity
disparities
between
fluoroalkyl
nonfluoroalkyl
radicals
in
cross-coupling
reactions,
highlighting
unique
nature
iron/B2pin2
systems.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(6), P. 1190 - 1195
Published: Feb. 3, 2024
A
Ni-catalyzed
reductive
dialkylation
of
8-aminoquinoline-tethered
aliphatic
alkenes
with
two
unactivated
alkyl
electrophiles
is
disclosed
here.
Key
to
the
development
this
transformation
combination
primary
(pseudo)halides
and
secondary
iodides
that
produce
products
in
a
single
regioselective
manner.
The
reaction
exhibits
good
functional
group
compatibility,
its
synthetic
utility
was
demonstrated
by
concise
synthesis
precursors
biologically
relevant
molecules.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(17), P. 5165 - 5173
Published: April 17, 2024
Tuning
electronic
characteristics
of
metal–ligand
bonds
based
on
reaction
pathways
to
achieve
efficient
catalytic
processes
has
been
widely
studied
and
proven
be
feasible
in
homogeneous
catalysis,
but
it
is
scarcely
investigated
heterogeneous
catalysis.
Herein,
we
demonstrate
the
regulation
configuration
Ir–O
an
Ir
single-atom
catalyst
according
borane
activation
mechanism.
Ir1/Ni(OH)x
are
found
more
electron-poor
than
those
Ir1/NiOx.
Despite
mild
solvent-free
conditions
ambient
temperature,
exhibits
outstanding
performance
for
hydroboration
alkenes,
furnishing
desired
alkylboronic
esters
with
a
turnover
frequency
value
≤3060
h–1
99%
anti-Markovnikov
selectivity,
which
significantly
better
that
Ir1/NiOx
(42
h–1).
It
further
as
active
centers
oxidative
so
benefit
H–B
bond
reductive
pinacolborane.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 19, 2024
Abstract
Visible-light
photocatalysis
has
evolved
as
a
powerful
technique
to
enable
controllable
radical
reactions.
Exploring
unique
photocatalytic
mode
for
obtaining
new
chemoselectivity
and
product
diversity
is
of
great
significance.
Herein,
we
present
photo-induced
chemoselective
1,2-diheteroarylation
unactivated
alkenes
utilizing
halopyridines
quinolines.
The
ring-fused
azaarenes
serve
not
only
substrate,
but
also
potential
precursors
halogen-atom
abstraction
pyridyl
generation
in
this
photocatalysis.
As
complement
metal
catalysis,
process
with
mild
redox
neutral
conditions
assembles
two
different
heteroaryl
groups
into
regioselectively
contribute
broad
substrates
scope.
obtained
products
containing
aza-arene
units
permit
various
further
diversifications,
demonstrating
the
synthetic
utility
protocol.
We
anticipate
that
protocol
will
trigger
advancement
alkyl/aryl
halides
activation.
